DE3370332D1 - 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them - Google Patents

6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them

Info

Publication number
DE3370332D1
DE3370332D1 DE8383401976T DE3370332T DE3370332D1 DE 3370332 D1 DE3370332 D1 DE 3370332D1 DE 8383401976 T DE8383401976 T DE 8383401976T DE 3370332 T DE3370332 T DE 3370332T DE 3370332 D1 DE3370332 D1 DE 3370332D1
Authority
DE
Germany
Prior art keywords
amino
carbon atoms
benzazepin
hydroxy
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383401976T
Other languages
English (en)
Inventor
Daniel Frechet
Lucien Nedelec
Guy Plassard
Neil Leslie Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst Roussel Vet SA France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3370332D1 publication Critical patent/DE3370332D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8383401976T 1982-10-12 1983-10-11 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them Expired DE3370332D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8217054A FR2534257A1 (fr) 1982-10-12 1982-10-12 Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire

Publications (1)

Publication Number Publication Date
DE3370332D1 true DE3370332D1 (en) 1987-04-23

Family

ID=9278183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383401976T Expired DE3370332D1 (en) 1982-10-12 1983-10-11 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them

Country Status (23)

Country Link
US (1) US4585770A (de)
EP (1) EP0107569B1 (de)
JP (1) JPS59130289A (de)
KR (1) KR900006753B1 (de)
AT (1) ATE25981T1 (de)
AU (1) AU559422B2 (de)
CA (2) CA1216847A (de)
DD (1) DD215784A5 (de)
DE (1) DE3370332D1 (de)
DK (1) DK163734C (de)
ES (1) ES8405802A1 (de)
FI (1) FI76340C (de)
FR (1) FR2534257A1 (de)
GR (1) GR78731B (de)
HU (1) HU188499B (de)
IE (1) IE59441B1 (de)
IL (1) IL69993A (de)
MX (1) MX8495A (de)
NZ (1) NZ205918A (de)
PH (1) PH20031A (de)
PT (1) PT77469B (de)
SU (2) SU1287753A3 (de)
ZA (1) ZA837480B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203667B (en) * 1986-12-11 1991-09-30 Roussel Uclaf Process for producing synergetic zootechnical compositions containing three components
FR2608047B1 (fr) * 1986-12-11 1990-08-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5,1-j-k/ /1/ benzazepin-2-(1h)-one
AU616390B2 (en) * 1986-12-11 1991-10-31 Hoechst Roussel Vet S.A. Zootechnical compositions containing a beta-adrenergic
FR2608046B1 (fr) * 1986-12-11 1989-03-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5, 1-j-k/ /1/benzazepin-2-(1h)-one
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
US7207289B2 (en) * 2004-05-20 2007-04-24 Intervet International B.V. Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
CA2666373A1 (en) * 2006-10-13 2008-04-17 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
WO2008050207A1 (en) * 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
US8629134B2 (en) * 2007-02-01 2014-01-14 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol
RU2442786C2 (ru) * 2007-03-31 2012-02-20 Интервет Интернэшнл Б.В. Способы получения зилпатерола и его солей
SG10201405734UA (en) * 2007-03-31 2014-10-30 Intervet Int Bv Processes For Making Zilpaterol And Salts Thereof
HK1136565A1 (en) * 2007-03-31 2010-07-02 Intervet Int Bv Processes for making zilpaterol and salts thereof
MX2009010499A (es) * 2007-03-31 2009-10-19 Intervet Int Bv Procesos para elaborar zilpaterol y sales del mismo.
EP1995248A1 (de) * 2007-05-23 2008-11-26 Evonik Degussa GmbH Verfahren zur Herstellung von Aminoalkoholen durch asymmetrische Hydrierung
CN101918001B (zh) 2007-12-06 2016-11-16 英特威国际有限公司 使用醋酸美仑孕酮和齐帕特罗或其盐的联合治疗
TW201033217A (en) * 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
EP2849577A1 (de) 2012-05-18 2015-03-25 Intervet International B.V. Verfahren zur leistungsverbesserung bei brathähnchen
WO2014095822A1 (en) * 2012-12-18 2014-06-26 Intervet International B.V. An improved process for making zilpaterol
MX2015012726A (es) 2013-03-15 2016-02-18 Intervet Int Bv Metodo para mejorar la eficiencia de la produccion de carne de animales bovinos.
CN104418808A (zh) * 2013-09-11 2015-03-18 中美华世通生物医药科技（武汉）有限公司 一种适于工业化生产的中间体Buzolic acid的制备方法
CN103554113B (zh) * 2013-09-25 2016-04-27 湖北美天生物科技有限公司 一种盐酸齐帕特罗的合成方法
CN107835643A (zh) 2015-07-21 2018-03-23 英特维特国际股份有限公司 一种新颖的齐帕特罗动物预混物制剂
EP3488705A1 (de) 2017-11-23 2019-05-29 Saviela AG Solubilisiertes wachstums-förderungsprodukt, oral zu verabreichen an tiere, sowie methode zur aufbereitung des entsprechenden futters
CN108752352B (zh) * 2018-04-18 2019-11-26 江苏凌云药业股份有限公司 一种盐酸齐帕特罗的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320439A (en) * 1943-06-01 Bottle carrier
US3200123A (en) * 1962-01-26 1965-08-10 Richardson Merreil Inc Imidazoquinolines
EP0034989B1 (de) * 1980-02-26 1983-10-05 Roussel-Uclaf Cycloheptindolol-Derivate und ihre Salze mit Säuren, ihre Herstellung, Verwendung als Heilmittel und Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
JPS59130289A (ja) 1984-07-26
FI76340B (fi) 1988-06-30
IE832387L (en) 1984-04-12
KR840006484A (ko) 1984-11-30
IL69993A0 (en) 1984-01-31
ATE25981T1 (de) 1987-04-15
CA1216847A (fr) 1987-01-20
FR2534257B1 (de) 1984-12-28
ES526390A0 (es) 1984-06-16
HU188499B (en) 1986-04-28
KR900006753B1 (ko) 1990-09-20
ZA837480B (en) 1984-11-28
ES8405802A1 (es) 1984-06-16
DK163734C (da) 1992-08-31
PH20031A (en) 1986-09-04
IL69993A (en) 1987-10-30
FI76340C (fi) 1988-10-10
US4585770A (en) 1986-04-29
DK466483D0 (da) 1983-10-11
AU559422B2 (en) 1987-03-12
DD215784A5 (de) 1984-11-21
MX8495A (es) 1993-09-01
EP0107569A1 (de) 1984-05-02
PT77469B (fr) 1986-05-07
JPH0454671B2 (de) 1992-08-31
FI833697A0 (fi) 1983-10-11
GR78731B (de) 1984-10-02
IE59441B1 (en) 1994-02-23
SU1287753A3 (ru) 1987-01-30
PT77469A (fr) 1983-11-01
EP0107569B1 (de) 1987-03-18
SU1384201A3 (ru) 1988-03-23
DK466483A (da) 1984-04-13
FR2534257A1 (fr) 1984-04-13
DK163734B (da) 1992-03-30
NZ205918A (en) 1985-12-13
FI833697A (fi) 1984-04-13
AU2005383A (en) 1984-04-19
CA1222246A (fr) 1987-05-26

Similar Documents

Publication Publication Date Title
DE3370332D1 (en) 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them
CA2289219A1 (en) 1-substituted, 2-substituted 1h-imidazo[4,5-c]quinolin-4-amines
DE3271269D1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
DE3160905D1 (en) Substituted imidazoles, their preparation and pharmaceutical compositions containing the same
ES8707243A1 (es) Un procedimiento para preparar derivados de tienopiridona
ES8304567A1 (es) "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".
IE780119L (en) IMIDAZO(1,2-a) QUINOLINE-2-CARBOXYLIC ACIDS
ES8404356A1 (es) Procedimiento de preparacion de nuevas pirimido-quinoxalinas.
ES8403919A1 (es) Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
IL70691A (en) 5-(4-vinyl-or 4-ethynyl-benzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrole-1-carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
DE3569376D1 (en) 1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
AU585981B2 (en) Benzo (IJ) quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and processes for preparing the same
ES449446A1 (es) Un procedimiento para la produccion de acidos 1-oxo-1h-6-pi-peridinogicamente activos y esteres de los mismos.
ES8201135A1 (es) Un procedimiento para preparar derivados de cicloheptilindo-lol
DE3160719D1 (en) Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them
ES8301991A1 (es) Procedimiento para la preparacion de 7-(2,6-dibromo-4-metil-fenil)-2,3-dihidro-imidazo 1,2-a, imidazoles.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST ROUSSEL VET S.A., ROMAINVILLE, FR