FI833697A - Foerfarande foer framstaellning av nya 6-amino-7-hydroxi-4,5,6,7-tetrahydro-imidazo-/4,5,l-j-k/-/1/benzazepin-2(1h)-on-derivat och deras salter - Google Patents

Foerfarande foer framstaellning av nya 6-amino-7-hydroxi-4,5,6,7-tetrahydro-imidazo-/4,5,l-j-k/-/1/benzazepin-2(1h)-on-derivat och deras salter Download PDF

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Publication number
FI833697A
FI833697A FI833697A FI833697A FI833697A FI 833697 A FI833697 A FI 833697A FI 833697 A FI833697 A FI 833697A FI 833697 A FI833697 A FI 833697A FI 833697 A FI833697 A FI 833697A
Authority
FI
Finland
Prior art keywords
amino
benzazepin
imidazo
tetrahydro
carbon atoms
Prior art date
Application number
FI833697A
Other languages
English (en)
Other versions
FI76340C (fi
FI833697A0 (fi
FI76340B (fi
Inventor
Daniel Frechet
Lucien Nedelec
Guy Plassard
Neil Leslie Brown
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI833697A0 publication Critical patent/FI833697A0/fi
Publication of FI833697A publication Critical patent/FI833697A/fi
Priority to FI861730A priority Critical patent/FI76341C/fi
Priority to FI870930A priority patent/FI870930A0/fi
Application granted granted Critical
Publication of FI76340B publication Critical patent/FI76340B/fi
Publication of FI76340C publication Critical patent/FI76340C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI833697A 1982-10-12 1983-10-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara nya 6-amino-7-hydroxi-4,5,6,7-tetrahydroimidazo- /4,5,1-j-k/-/1/bensazepin-2-(1h)-on-derivat och deras salter. FI76340C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI861730A FI76341C (fi) 1982-10-12 1986-04-24 Foerfarande foer framstaellning av 5,6-dihydroimidazo/4,5,1-j-k//1/benzazepin-2,7(1h,4h)-dion.
FI870930A FI870930A0 (fi) 1982-10-12 1987-03-03 Foerfarande foer framstaellning av 4,5-dihydroimidazo/4,5,1-j-k//1/benzazepin-2,7-(1h,6h) dion.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8217054 1982-10-12
FR8217054A FR2534257A1 (fr) 1982-10-12 1982-10-12 Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire

Publications (4)

Publication Number Publication Date
FI833697A0 FI833697A0 (fi) 1983-10-11
FI833697A true FI833697A (fi) 1984-04-13
FI76340B FI76340B (fi) 1988-06-30
FI76340C FI76340C (fi) 1988-10-10

Family

ID=9278183

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833697A FI76340C (fi) 1982-10-12 1983-10-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara nya 6-amino-7-hydroxi-4,5,6,7-tetrahydroimidazo- /4,5,1-j-k/-/1/bensazepin-2-(1h)-on-derivat och deras salter.

Country Status (23)

Country Link
US (1) US4585770A (fi)
EP (1) EP0107569B1 (fi)
JP (1) JPS59130289A (fi)
KR (1) KR900006753B1 (fi)
AT (1) ATE25981T1 (fi)
AU (1) AU559422B2 (fi)
CA (2) CA1216847A (fi)
DD (1) DD215784A5 (fi)
DE (1) DE3370332D1 (fi)
DK (1) DK163734C (fi)
ES (1) ES8405802A1 (fi)
FI (1) FI76340C (fi)
FR (1) FR2534257A1 (fi)
GR (1) GR78731B (fi)
HU (1) HU188499B (fi)
IE (1) IE59441B1 (fi)
IL (1) IL69993A (fi)
MX (1) MX8495A (fi)
NZ (1) NZ205918A (fi)
PH (1) PH20031A (fi)
PT (1) PT77469B (fi)
SU (2) SU1287753A3 (fi)
ZA (1) ZA837480B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608046B1 (fr) * 1986-12-11 1989-03-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5, 1-j-k/ /1/benzazepin-2-(1h)-one
HU203667B (en) * 1986-12-11 1991-09-30 Roussel Uclaf Process for producing synergetic zootechnical compositions containing three components
AU616390B2 (en) * 1986-12-11 1991-10-31 Hoechst Roussel Vet S.A. Zootechnical compositions containing a beta-adrenergic
FR2608047B1 (fr) * 1986-12-11 1990-08-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5,1-j-k/ /1/ benzazepin-2-(1h)-one
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
US7207289B2 (en) * 2004-05-20 2007-04-24 Intervet International B.V. Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
CN101535315A (zh) * 2006-10-13 2009-09-16 辉瑞有限公司 用作家畜动物的同化激素类药的杂环化合物
WO2008050207A1 (en) * 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
US8629134B2 (en) * 2007-02-01 2014-01-14 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol
HK1136565A1 (en) * 2007-03-31 2010-07-02 Intervet Int Bv Processes for making zilpaterol and salts thereof
MX2009010499A (es) * 2007-03-31 2009-10-19 Intervet Int Bv Procesos para elaborar zilpaterol y sales del mismo.
KR20140051421A (ko) * 2007-03-31 2014-04-30 인터벳 인터내셔널 비.브이. 질파테롤 및 이의 염의 제조 방법
RU2442786C2 (ru) * 2007-03-31 2012-02-20 Интервет Интернэшнл Б.В. Способы получения зилпатерола и его солей
EP1995248A1 (en) * 2007-05-23 2008-11-26 Evonik Degussa GmbH Process for the production of amino alcohols by asymmetric hydrogenation
WO2009073756A1 (en) 2007-12-06 2009-06-11 Intervet International B.V. Combination therapies using melengestrol acetate and zilpaterol or its salts
TW201033217A (en) * 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
US20130310367A1 (en) 2012-05-18 2013-11-21 John A. Rogers Method of enhancing performance in broiler chickens
US9630967B2 (en) 2012-12-18 2017-04-25 Intervet Inc. Process for making zilpaterol
MX2015012726A (es) 2013-03-15 2016-02-18 Intervet Int Bv Metodo para mejorar la eficiencia de la produccion de carne de animales bovinos.
CN104418808A (zh) * 2013-09-11 2015-03-18 中美华世通生物医药科技（武汉）有限公司 一种适于工业化生产的中间体Buzolic acid的制备方法
CN103554113B (zh) * 2013-09-25 2016-04-27 湖北美天生物科技有限公司 一种盐酸齐帕特罗的合成方法
RU2018105703A (ru) 2015-07-21 2019-08-22 Интервет Интернэшнл Б.В. Новый состав премикса для животных на основе зилпатерола
EP3488705A1 (en) 2017-11-23 2019-05-29 Saviela AG Solubilized growth promoting product to be applied orally to animals and method for the respective feed preparation
CN108752352B (zh) * 2018-04-18 2019-11-26 江苏凌云药业股份有限公司 一种盐酸齐帕特罗的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320439A (en) * 1943-06-01 Bottle carrier
US3200123A (en) * 1962-01-26 1965-08-10 Richardson Merreil Inc Imidazoquinolines
DE3161072D1 (en) * 1980-02-26 1983-11-10 Roussel Uclaf Cycloheptindolol derivatives and their acid-addition salts, their preparation, their use as medicines and composition containing them

Also Published As

Publication number Publication date
NZ205918A (en) 1985-12-13
JPH0454671B2 (fi) 1992-08-31
ZA837480B (en) 1984-11-28
JPS59130289A (ja) 1984-07-26
IL69993A0 (en) 1984-01-31
FI76340C (fi) 1988-10-10
KR840006484A (ko) 1984-11-30
DE3370332D1 (en) 1987-04-23
HU188499B (en) 1986-04-28
DK466483D0 (da) 1983-10-11
SU1287753A3 (ru) 1987-01-30
MX8495A (es) 1993-09-01
PT77469A (fr) 1983-11-01
FR2534257A1 (fr) 1984-04-13
EP0107569A1 (fr) 1984-05-02
DK163734B (da) 1992-03-30
US4585770A (en) 1986-04-29
IE832387L (en) 1984-04-12
FR2534257B1 (fi) 1984-12-28
DK466483A (da) 1984-04-13
KR900006753B1 (ko) 1990-09-20
AU2005383A (en) 1984-04-19
ATE25981T1 (de) 1987-04-15
CA1222246A (fr) 1987-05-26
ES526390A0 (es) 1984-06-16
CA1216847A (fr) 1987-01-20
PT77469B (fr) 1986-05-07
SU1384201A3 (ru) 1988-03-23
DD215784A5 (de) 1984-11-21
EP0107569B1 (fr) 1987-03-18
ES8405802A1 (es) 1984-06-16
FI833697A0 (fi) 1983-10-11
AU559422B2 (en) 1987-03-12
DK163734C (da) 1992-08-31
GR78731B (fi) 1984-10-02
FI76340B (fi) 1988-06-30
IL69993A (en) 1987-10-30
IE59441B1 (en) 1994-02-23
PH20031A (en) 1986-09-04

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MA Patent expired

Owner name: HOECHST ROUSSEL VET S.A.