ES8301991A1 - Procedimiento para la preparacion de 7-(2,6-dibromo-4-metil-fenil)-2,3-dihidro-imidazo 1,2-a, imidazoles. - Google Patents
Procedimiento para la preparacion de 7-(2,6-dibromo-4-metil-fenil)-2,3-dihidro-imidazo 1,2-a, imidazoles.Info
- Publication number
- ES8301991A1 ES8301991A1 ES507016A ES507016A ES8301991A1 ES 8301991 A1 ES8301991 A1 ES 8301991A1 ES 507016 A ES507016 A ES 507016A ES 507016 A ES507016 A ES 507016A ES 8301991 A1 ES8301991 A1 ES 8301991A1
- Authority
- ES
- Spain
- Prior art keywords
- acid addition
- addition salts
- dihydroimidazo
- dibromo
- imidazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 7-(2,6-DIBROMO-4-METIL-FENIL) -2,3-DIHIDRO-IMIDAZO <014>1,2-A<015> IMIDAZOLES, DE FORMULA GENERAL (I), EN DONDE R SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO METILO, ASI COMO DE SUS SALES POR ADICION DE ACIDOS. CONSISTE EN HACER REACCIONAR 2-(2,6-DIBROMO-4-METIL-FENIL)-IMINO- IMIDAZOLINA DE FORMULA (II), CON UN COMPUESTO CON AGRUPACION GENERAL (III), EN DONDE R TIENE EL SIGNIFICADO YA INDICADO, Y X SIGNIFICA UN ATOMO DE CLORO, BROMO O YODO. EL COMPUESTO OBTENIDO PUEDE TRANSFORMARSE EN UNA SAL POR ADICION DE ACIDO. LA REACCION SE LLEVA A EFECTO EN PRESENCIA DE UN DISOLVENTE ORGANICO POLAR O NO POLAR, Y A TEMPERATURAS COMPRENDIDAS ENTRE 60 Y 180 GRADOS. DE APLICACION EN PREPARACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803042636 DE3042636A1 (de) | 1980-11-12 | 1980-11-12 | Neue 7-(2,6-dibrom-4-methylphenyl)-2,3-dihydro-imidazo(1,2-a)imidazole, deren saeureadditionssalze, diese enhthaltende arzneimittel und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301991A1 true ES8301991A1 (es) | 1982-12-16 |
| ES507016A0 ES507016A0 (es) | 1982-12-16 |
Family
ID=6116582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507016A Granted ES507016A0 (es) | 1980-11-12 | 1981-11-11 | Procedimiento para la preparacion de 7-(2,6-dibromo-4-metil-fenil)-2,3-dihidro-imidazo 1,2-a, imidazoles. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4409235A (es) |
| EP (1) | EP0051809A1 (es) |
| JP (1) | JPS57109788A (es) |
| KR (1) | KR880000851B1 (es) |
| AR (1) | AR228376A1 (es) |
| AU (1) | AU548784B2 (es) |
| CA (1) | CA1171090A (es) |
| CS (1) | CS223848B2 (es) |
| DD (1) | DD208154A5 (es) |
| DE (1) | DE3042636A1 (es) |
| DK (1) | DK153151C (es) |
| ES (1) | ES507016A0 (es) |
| FI (1) | FI71561C (es) |
| GB (1) | GB2086900B (es) |
| GR (1) | GR81331B (es) |
| HU (1) | HU182413B (es) |
| IE (1) | IE53482B1 (es) |
| IL (1) | IL64242A (es) |
| NO (1) | NO156691C (es) |
| NZ (1) | NZ198940A (es) |
| PH (1) | PH18610A (es) |
| PL (1) | PL133210B1 (es) |
| PT (1) | PT73971B (es) |
| ZA (1) | ZA817788B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2118261A1 (de) * | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| US3865836A (en) * | 1972-12-08 | 1975-02-11 | Janssen Pharmaceutica Nv | Bicyclic imidazoles |
| DE2827617A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Sohn Ingelheim | Neue imidazo eckige klammer auf 1,2- alpha eckige klammer zu imidazole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
-
1980
- 1980-11-12 DE DE19803042636 patent/DE3042636A1/de not_active Withdrawn
-
1981
- 1981-10-28 EP EP81109106A patent/EP0051809A1/de not_active Ceased
- 1981-11-09 AR AR287379A patent/AR228376A1/es active
- 1981-11-09 IL IL64242A patent/IL64242A/xx unknown
- 1981-11-10 FI FI813562A patent/FI71561C/fi not_active IP Right Cessation
- 1981-11-10 CS CS818256A patent/CS223848B2/cs unknown
- 1981-11-10 GR GR66489A patent/GR81331B/el unknown
- 1981-11-10 CA CA000389832A patent/CA1171090A/en not_active Expired
- 1981-11-10 DD DD81234740A patent/DD208154A5/de unknown
- 1981-11-11 AU AU77391/81A patent/AU548784B2/en not_active Ceased
- 1981-11-11 JP JP56180924A patent/JPS57109788A/ja active Pending
- 1981-11-11 HU HU813374A patent/HU182413B/hu not_active IP Right Cessation
- 1981-11-11 PT PT73971A patent/PT73971B/pt unknown
- 1981-11-11 PL PL1981233772A patent/PL133210B1/pl unknown
- 1981-11-11 DK DK499381A patent/DK153151C/da not_active IP Right Cessation
- 1981-11-11 NZ NZ198940A patent/NZ198940A/en unknown
- 1981-11-11 ZA ZA817788A patent/ZA817788B/xx unknown
- 1981-11-11 NO NO813822A patent/NO156691C/no unknown
- 1981-11-11 ES ES507016A patent/ES507016A0/es active Granted
- 1981-11-11 GB GB8134005A patent/GB2086900B/en not_active Expired
- 1981-11-11 IE IE2641/81A patent/IE53482B1/en unknown
- 1981-11-11 KR KR1019810004323A patent/KR880000851B1/ko active
-
1982
- 1982-08-02 US US06/404,538 patent/US4409235A/en not_active Expired - Fee Related
-
1983
- 1983-05-25 PH PH28957A patent/PH18610A/en unknown
Also Published As
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