DD202430A5 - Verfahren zur herstellung von dihydropyridinen - Google Patents

Verfahren zur herstellung von dihydropyridinen Download PDF

Info

Publication number
DD202430A5
DD202430A5 DD82238073A DD23807382A DD202430A5 DD 202430 A5 DD202430 A5 DD 202430A5 DD 82238073 A DD82238073 A DD 82238073A DD 23807382 A DD23807382 A DD 23807382A DD 202430 A5 DD202430 A5 DD 202430A5
Authority
DD
German Democratic Republic
Prior art keywords
alkyl
formula
halogen
aryl
ethyl
Prior art date
Application number
DD82238073A
Other languages
German (de)
English (en)
Inventor
Simon F Campbell
Peter E Cross
John K Stubbs
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DD202430A5 publication Critical patent/DD202430A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD82238073A 1981-03-14 1982-03-11 Verfahren zur herstellung von dihydropyridinen DD202430A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8108088 1981-03-14

Publications (1)

Publication Number Publication Date
DD202430A5 true DD202430A5 (de) 1983-09-14

Family

ID=10520395

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82238073A DD202430A5 (de) 1981-03-14 1982-03-11 Verfahren zur herstellung von dihydropyridinen

Country Status (24)

Country Link
US (1) US4430333A (fr)
EP (1) EP0060674B1 (fr)
JP (1) JPS57206659A (fr)
KR (1) KR860001579B1 (fr)
AT (1) ATE15660T1 (fr)
AU (1) AU529854B2 (fr)
CA (1) CA1205480A (fr)
CS (1) CS228917B2 (fr)
DD (1) DD202430A5 (fr)
DE (1) DE3266272D1 (fr)
DK (1) DK155601C (fr)
ES (2) ES510402A0 (fr)
FI (1) FI78470C (fr)
GR (1) GR75895B (fr)
HU (1) HU187657B (fr)
IE (1) IE52632B1 (fr)
IL (1) IL65222A (fr)
NO (1) NO159085C (fr)
NZ (1) NZ199990A (fr)
PH (1) PH17585A (fr)
PL (2) PL131190B1 (fr)
PT (1) PT74571B (fr)
YU (2) YU42461B (fr)
ZA (1) ZA821670B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
EP0094159B1 (fr) * 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dérivés de la dihydropyridine, leur préparation et leur application
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
EP0107293A3 (fr) * 1982-09-04 1984-06-06 Pfizer Limited Dihydropyridines
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
PT77842B (en) * 1982-12-21 1986-05-05 Pfizer Process for preparing dihydropyridines
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
US4603135A (en) * 1983-10-17 1986-07-29 Takeda Chemical Industries, Ltd. Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
EP0168841B1 (fr) * 1983-12-19 1988-09-28 Pfizer Limited Intermédiaire dihydropyridine
GB8401288D0 (en) * 1984-01-18 1984-02-22 Pfizer Ltd Therapeutic agents
US4755512A (en) * 1984-04-11 1988-07-05 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities
US4895846A (en) * 1984-04-11 1990-01-23 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
GB8414518D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Therapeutic agents
GB8415386D0 (en) * 1984-06-15 1984-07-18 Pfizer Ltd Therapeutic agents
GR851819B (fr) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
US4652573A (en) * 1985-03-14 1987-03-24 Nelson Research & Development Co. Calcium antagonist N-hetero ester 1,4-dihydropyridines
IT1204421B (it) * 1986-06-27 1989-03-01 Boehringer Biochemia Srl 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
FR2586417B1 (fr) * 1985-08-21 1991-08-30 Glaxo Spa Composes heterocycliques, leur preparation et composition pharmaceutique
EP0226271B1 (fr) * 1985-08-21 1990-11-22 GLAXO S.p.A. Dihydro-1,4 pyridines, leur préparation et composition pharmaceutique
DE3531498A1 (de) * 1985-09-04 1987-03-05 Bayer Ag Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
AU7810087A (en) * 1986-08-14 1988-03-08 Byk Gulden Lomberg Chemische Fabrik Gmbh New piperidines
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
GB8710493D0 (en) * 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
IT1205114B (it) * 1987-05-29 1989-03-15 Boehringer Biochemia Srl 2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
US4978533A (en) * 1988-11-01 1990-12-18 Pharmaconsult, Inc. Liquid nifidipine composition
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
ES2151850B1 (es) * 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
BR0116557A (pt) * 2000-12-29 2003-10-28 Pfizer Ltd Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
WO2016155815A1 (fr) 2015-04-01 2016-10-06 Ceva Sante Animale Forme posologique orale solide d'amlodipine et usages vétérinaires correspondants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943140A (en) 1972-09-30 1976-03-09 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
DE2248150A1 (de) 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946027A (en) 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
BE843576A (fr) 1975-04-03 1976-12-29 Derives de 1,4-dihydropyridine et leur procede de preparation
GB1552911A (en) 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2658183A1 (de) 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en) 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
DE2715182A1 (de) 1977-04-05 1978-10-19 Bayer Ag 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4307103A (en) 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
ES8305330A1 (es) 1983-04-01
DE3266272D1 (en) 1985-10-24
PL132199B1 (en) 1985-02-28
EP0060674A1 (fr) 1982-09-22
PT74571B (en) 1984-11-27
FI78470C (fi) 1989-08-10
US4430333A (en) 1984-02-07
DK155601C (da) 1989-09-11
PL235363A1 (en) 1983-03-14
FI820840L (fi) 1982-09-15
ES518489A0 (es) 1984-01-16
PL131190B1 (en) 1984-10-31
IL65222A (en) 1985-08-30
IL65222A0 (en) 1982-05-31
ES8402273A1 (es) 1984-01-16
IE52632B1 (en) 1988-01-06
AU529854B2 (en) 1983-06-23
PT74571A (en) 1982-04-01
KR860001579B1 (ko) 1986-10-10
ZA821670B (en) 1983-01-26
IE820572L (en) 1982-09-14
ES510402A0 (es) 1983-04-01
NZ199990A (en) 1984-07-06
PL238960A1 (en) 1983-07-18
AU8136482A (en) 1982-11-04
DK155601B (da) 1989-04-24
ATE15660T1 (de) 1985-10-15
NO820825L (no) 1982-09-15
JPS6155907B2 (fr) 1986-11-29
HU187657B (en) 1986-02-28
FI78470B (fi) 1989-04-28
YU42461B (en) 1988-08-31
JPS57206659A (en) 1982-12-18
YU55082A (en) 1984-12-31
PH17585A (en) 1984-10-02
YU42902B (en) 1988-12-31
NO159085B (no) 1988-08-22
KR830009025A (ko) 1983-12-17
GR75895B (fr) 1984-08-02
DK109982A (da) 1982-09-15
YU155884A (en) 1985-03-20
EP0060674B1 (fr) 1985-09-18
NO159085C (no) 1988-11-30
CA1205480A (fr) 1986-06-03
CS228917B2 (en) 1984-05-14

Similar Documents

Publication Publication Date Title
DD202430A5 (de) Verfahren zur herstellung von dihydropyridinen
DE3787346T2 (de) Dihydropyridin-Derivate, ihre Herstellung und ihre Verwendung.
DD218887A5 (de) Verfahren zur herstellung von 1,4-dihydropyridinen
CH635323A5 (de) Verfahren zur herstellung von neuen in 2-position substituierten 1,4-dihydropyridin-derivaten.
EP0260675A1 (fr) Dérivés substitués de l'[aminophényl N-substitué]-4 dihydro-1,4 pyridine, leur procédé de préparation et médicaments les contenant
CH664757A5 (de) Pharmazeutisch nuetzliche dihydropyridinylcarbonsaeureamide und ester.
NZ528362A (en) Novel amlodipine camsylate and method for preparing thereof
DD262023A5 (de) Verfahren zur herstellung von dihydropyridinen
EP0296316A1 (fr) Enantiomères de dihydro-1,4-pyridine
DD282008A5 (de) Verfahren zur herstellung von neuen 1,4-dihydropyridinderivaten
CH647519A5 (de) Bluthochdruck senkende amine.
CH654837A5 (de) Cyclische dihydropyridylimidatester, verfahren zu ihrer herstellung und pharmazeutische mittel.
DE69002338T2 (de) Pyrrolidin-Derivate und ihre pharmazeutische Verwendung.
DE60015844T2 (de) Pyridin- und Piperidinderivate zur Behandlung von neurodegenerativen Erkrankungen
EP0234196A1 (fr) Pipérazides d'acide 1,4-dihydropyridine-3-carboxylique, procédé pour leur préparation et leur utilisation dans des médicaments
DE3607821A1 (de) Aminoester-dihydropyridine, verfahren zur herstellung und ihre verwendung
DE68912252T2 (de) Imidazolantiarrythmische Mittel.
DD296683A5 (de) Verfahren zur herstellung von enantiomerenreinen dihydrophyridinamiden
DE3816361A1 (de) 1,4-dihydropyridindicarbonsaeure-(-)-menthylester
EP0657432B1 (fr) 1,4-Dihydropyridines substitués par un groupement phényle avec une activité cérébrale
DE3628215C2 (de) 1,4-Dihydro-2-alkylenamino-3,5-dicarbonester-4-(2-propenyl)-phenyl-pyridine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
EP0244595A2 (fr) Dérivés de dihydropyridine, leur procédé de préparation et leur application comme médicaments
DD209816A5 (de) Verfahren zur herstellung von dihydropyridinen
DE69632206T2 (de) (2-piperidin-1-yl-4-substituierte)-4-amino-2-chinazolin-derivate mit antihypertensiver wirkung, verfahren zu ihrer herstellung und ihrem pharmazeutischen gebrauch
DD273437A5 (de) Verfahren zur herstellung von dihydropyridin-derivaten

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee