DD157613A5 - Verfahren zur herstellung eines insulins oder insulinanalogs - Google Patents

Verfahren zur herstellung eines insulins oder insulinanalogs Download PDF

Info

Publication number
DD157613A5
DD157613A5 DD81228623A DD22862381A DD157613A5 DD 157613 A5 DD157613 A5 DD 157613A5 DD 81228623 A DD81228623 A DD 81228623A DD 22862381 A DD22862381 A DD 22862381A DD 157613 A5 DD157613 A5 DD 157613A5
Authority
DD
German Democratic Republic
Prior art keywords
insulin
chain
sulfonate
item
solution
Prior art date
Application number
DD81228623A
Other languages
German (de)
English (en)
Inventor
Ronald E Chance
James A Hoffmann
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD157613A5 publication Critical patent/DD157613A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DD81228623A 1980-03-27 1981-03-26 Verfahren zur herstellung eines insulins oder insulinanalogs DD157613A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13439080A 1980-03-27 1980-03-27

Publications (1)

Publication Number Publication Date
DD157613A5 true DD157613A5 (de) 1982-11-24

Family

ID=22463156

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81228623A DD157613A5 (de) 1980-03-27 1981-03-26 Verfahren zur herstellung eines insulins oder insulinanalogs

Country Status (28)

Country Link
EP (1) EP0037256B1 (fr)
JP (1) JPS56154443A (fr)
KR (1) KR840000947B1 (fr)
AR (1) AR227305A1 (fr)
AT (1) ATE4638T1 (fr)
AU (1) AU540645B2 (fr)
CA (1) CA1155109A (fr)
CS (1) CS236463B2 (fr)
DD (1) DD157613A5 (fr)
DE (1) DE3160862D1 (fr)
DK (1) DK149756C (fr)
EG (1) EG15248A (fr)
ES (1) ES500750A0 (fr)
FI (1) FI810918L (fr)
GB (1) GB2072680B (fr)
GR (1) GR73619B (fr)
HU (1) HU185416B (fr)
IE (1) IE51608B1 (fr)
IL (1) IL62483A (fr)
NO (1) NO151897C (fr)
NZ (1) NZ196610A (fr)
PH (1) PH16153A (fr)
PL (1) PL128599B1 (fr)
PT (1) PT72733B (fr)
RO (1) RO81640B (fr)
SU (1) SU1327790A3 (fr)
YU (1) YU76981A (fr)
ZA (1) ZA811970B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451396A (en) * 1983-08-01 1984-05-29 Eli Lilly And Company Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JP2606100Y2 (ja) * 1992-04-15 2000-09-11 松下電器産業株式会社 電気掃除機とそのパックフィルター
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法

Also Published As

Publication number Publication date
DE3160862D1 (en) 1983-10-20
EP0037256A1 (fr) 1981-10-07
KR830004855A (ko) 1983-07-20
PL230295A1 (fr) 1981-11-13
NO151897B (no) 1985-03-18
PT72733A (en) 1981-04-01
EP0037256B1 (fr) 1983-09-14
CS236463B2 (en) 1985-05-15
CA1155109A (fr) 1983-10-11
NZ196610A (en) 1984-03-16
PH16153A (en) 1983-07-12
GB2072680B (en) 1983-09-21
NO151897C (no) 1985-06-26
GB2072680A (en) 1981-10-07
JPS56154443A (en) 1981-11-30
IL62483A0 (en) 1981-05-20
NO811038L (no) 1981-09-28
GR73619B (fr) 1984-03-26
RO81640B (ro) 1983-04-30
ES8207551A1 (es) 1982-09-16
AR227305A1 (es) 1982-10-15
HU185416B (en) 1985-02-28
ES500750A0 (es) 1982-09-16
DK136581A (da) 1981-09-28
FI810918L (fi) 1981-09-28
EG15248A (en) 1985-12-31
AU6884481A (en) 1981-10-01
AU540645B2 (en) 1984-11-29
DK149756C (da) 1987-06-15
IE51608B1 (en) 1987-01-21
PT72733B (en) 1982-03-22
JPS6318960B2 (fr) 1988-04-20
ZA811970B (en) 1982-11-24
IE810680L (en) 1981-09-27
PL128599B1 (en) 1984-02-29
YU76981A (en) 1983-09-30
IL62483A (en) 1984-05-31
RO81640A (fr) 1983-04-29
SU1327790A3 (ru) 1987-07-30
ATE4638T1 (de) 1983-09-15
KR840000947B1 (ko) 1984-07-01
DK149756B (da) 1986-09-22

Similar Documents

Publication Publication Date Title
US4421685A (en) Process for producing an insulin
DE3686654T2 (de) Verfahren zur isolierung rekombinanter polypeptide in biologisch aktiver form.
DE3586987T2 (de) Methode zur foerderung einer disulfidverbindung in rekombinanten proteinen und formulationen, welche diese produkte enthalten.
EP0376156B1 (fr) Nouveaux dérivés d'insuline, procédé de leur fabrication, leur utilisation et composés pharmaceutiques les contenant
DE3687500T2 (de) Insulinabkoemmlinge und arzneimittel die diese enthalten.
DE3104949C2 (de) Verfahren zur Herstellung von Threonin↑B↑↑3↑↑0↑-Estern des Humaninsulins, demgemäß hergestellte Threonin↑B↑↑3↑↑0↑-Ester des Humaninsulins sowie Verfahren zur Herstellung von Humaninsulin unter Verwendung derartiger Threonin↑B↑↑3↑↑0↑-Ester des Humaninsulins
EP1161452A2 (fr) Dimeres d'insuline pontes de maniere covalente
DE69636739T2 (de) Verfahren zur rückfaltung von menschlichem activin a
DD157613A5 (de) Verfahren zur herstellung eines insulins oder insulinanalogs
DE69911024T2 (de) Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden
DD157612A5 (de) Verfahren zur herstellung eines insulinvorlaeufers
DE3686257T2 (de) Herstellung von polypeptiden.
DE3884660T2 (de) Verfahren zur selektiven Spaltung der Peptidbindung.
EP0381958B1 (fr) Préparation de précurseurs d'insuline
DE68913080T2 (de) S-sulfonierte Calcitonin-Derivate.
DE3687702T2 (de) Schutz von methionin in einer polypeptid-kette von irreversibler oxydation.
EP0379162A2 (fr) Procédé de renaturation de faux recombinants de précurseurs d'insuline
DE69031596T2 (de) Verfahren zur herstellung eines proteins gehörend zu der klasse der cytokine, das mindestens eine intramolekulare disulfidbrücke enthält, durch oxidation bei einem ph-wert kleiner als 5.0 des entsprechenden rekombinanten reduzierten proteins
DE3687246T2 (de) Antitumor-polypeptid und dessen methode zur herstellung.
EP0133308B1 (fr) Agent pour le contrôle de l'appétit et son procédé de préparation
DE2209836C3 (de) Neue Insulinderivate sowie Verfahren zu Ihrer Herstellung und diese enthaltende Arzneimittel
DE4139000A1 (de) Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf
DE3881396T2 (de) Nieren-wachstumsbeschleuniger und verfahren zu seiner herstellung.
EP0219839A2 (fr) Dérivé de l'interleukine-2, sa préparation et utilisation
DE3828287A1 (de) Verfahren zur reduktion von methioninsulfoxidresten