KR830004855A - 인슐린의 제조방법 - Google Patents
인슐린의 제조방법 Download PDFInfo
- Publication number
- KR830004855A KR830004855A KR1019810000990A KR810000990A KR830004855A KR 830004855 A KR830004855 A KR 830004855A KR 1019810000990 A KR1019810000990 A KR 1019810000990A KR 810000990 A KR810000990 A KR 810000990A KR 830004855 A KR830004855 A KR 830004855A
- Authority
- KR
- South Korea
- Prior art keywords
- insulin
- chain
- homologue
- total
- reducing agent
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 14
- 102000004877 Insulin Human genes 0.000 title claims 7
- 108090001061 Insulin Proteins 0.000 title claims 7
- 229940125396 insulin Drugs 0.000 title claims 7
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- A-쇄의 S-설폰화된 형태, B-쇄의 S-설폰화된 형태 및 티올 환원제를 수용성매질중에서 함께 반응시켜 pH가 약 8 내지 12이고 총단백질 농도가 ml당 약 0.1 내지 50mg이며, 티올 환원제를 A- 및 B-쇄 S-설포네이트 총량중에 존재하는 각 -SSO3- 그룹당 총 약 0.4 내지 2.5-SH 그룹을 수득할 수 있는 량 함유하는 혼합물을 제조하여 혼합물을 약 0 내지 25℃의 온도이고 산소원이 공급되는 곳에서 유지시킴으로써 인슐린 또는 인슐린 동족체를 생성시킴을 특징으로 하는 인슐린 또는 인슐린 동족체의 A-쇄와 B-쇄를 결합시켜 인슐린 또는 인슐린 동족체를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13439080A | 1980-03-27 | 1980-03-27 | |
| US134390 | 1980-03-27 | ||
| US134,390 | 1980-03-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830004855A true KR830004855A (ko) | 1983-07-20 |
| KR840000947B1 KR840000947B1 (ko) | 1984-07-01 |
Family
ID=22463156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810000990A KR840000947B1 (ko) | 1980-03-27 | 1981-03-26 | 인슐린의 제조방법 |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0037256B1 (ko) |
| JP (1) | JPS56154443A (ko) |
| KR (1) | KR840000947B1 (ko) |
| AR (1) | AR227305A1 (ko) |
| AT (1) | ATE4638T1 (ko) |
| AU (1) | AU540645B2 (ko) |
| CA (1) | CA1155109A (ko) |
| CS (1) | CS236463B2 (ko) |
| DD (1) | DD157613A5 (ko) |
| DE (1) | DE3160862D1 (ko) |
| DK (1) | DK149756C (ko) |
| EG (1) | EG15248A (ko) |
| ES (1) | ES8207551A1 (ko) |
| FI (1) | FI810918L (ko) |
| GB (1) | GB2072680B (ko) |
| GR (1) | GR73619B (ko) |
| HU (1) | HU185416B (ko) |
| IE (1) | IE51608B1 (ko) |
| IL (1) | IL62483A (ko) |
| NO (1) | NO151897C (ko) |
| NZ (1) | NZ196610A (ko) |
| PH (1) | PH16153A (ko) |
| PL (1) | PL128599B1 (ko) |
| PT (1) | PT72733B (ko) |
| RO (1) | RO81640B (ko) |
| SU (1) | SU1327790A3 (ko) |
| YU (1) | YU76981A (ko) |
| ZA (1) | ZA811970B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451396A (en) * | 1983-08-01 | 1984-05-29 | Eli Lilly And Company | Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides |
| DE3501641A1 (de) * | 1985-01-19 | 1986-07-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen |
| US4835251A (en) * | 1986-06-23 | 1989-05-30 | Genetech, Inc. | Method of chain combination |
| GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| JP2606100Y2 (ja) * | 1992-04-15 | 2000-09-11 | 松下電器産業株式会社 | 電気掃除機とそのパックフィルター |
| JP3406244B2 (ja) * | 1999-04-30 | 2003-05-12 | 伊藤ハム株式会社 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
-
1981
- 1981-03-24 YU YU00769/81A patent/YU76981A/xx unknown
- 1981-03-24 PL PL1981230295A patent/PL128599B1/pl unknown
- 1981-03-24 EG EG159/81A patent/EG15248A/xx active
- 1981-03-24 PH PH25409A patent/PH16153A/en unknown
- 1981-03-24 NZ NZ196610A patent/NZ196610A/en unknown
- 1981-03-24 ZA ZA00811970A patent/ZA811970B/xx unknown
- 1981-03-24 CA CA000373706A patent/CA1155109A/en not_active Expired
- 1981-03-24 RO RO103807A patent/RO81640B/ro unknown
- 1981-03-25 FI FI810918A patent/FI810918L/fi not_active Application Discontinuation
- 1981-03-25 IL IL62483A patent/IL62483A/xx not_active IP Right Cessation
- 1981-03-25 PT PT72733A patent/PT72733B/pt unknown
- 1981-03-26 GB GB8109542A patent/GB2072680B/en not_active Expired
- 1981-03-26 SU SU813269596A patent/SU1327790A3/ru active
- 1981-03-26 AT AT81301306T patent/ATE4638T1/de not_active IP Right Cessation
- 1981-03-26 DK DK136581A patent/DK149756C/da not_active IP Right Cessation
- 1981-03-26 IE IE680/81A patent/IE51608B1/en not_active IP Right Cessation
- 1981-03-26 GR GR64491A patent/GR73619B/el unknown
- 1981-03-26 EP EP81301306A patent/EP0037256B1/en not_active Expired
- 1981-03-26 NO NO811038A patent/NO151897C/no unknown
- 1981-03-26 HU HU81771A patent/HU185416B/hu not_active IP Right Cessation
- 1981-03-26 DD DD81228623A patent/DD157613A5/de unknown
- 1981-03-26 KR KR1019810000990A patent/KR840000947B1/ko active
- 1981-03-26 DE DE8181301306T patent/DE3160862D1/de not_active Expired
- 1981-03-26 ES ES500750A patent/ES8207551A1/es not_active Expired
- 1981-03-27 CS CS812273A patent/CS236463B2/cs unknown
- 1981-03-27 JP JP4612481A patent/JPS56154443A/ja active Granted
- 1981-03-27 AU AU68844/81A patent/AU540645B2/en not_active Ceased
- 1981-03-27 AR AR284772A patent/AR227305A1/es active
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