CZ295256B6 - Benzodiazepinové deriváty jako modulátory receptoru GABA A - Google Patents

Benzodiazepinové deriváty jako modulátory receptoru GABA A Download PDF

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Publication number
CZ295256B6
CZ295256B6 CZ20031597A CZ20031597A CZ295256B6 CZ 295256 B6 CZ295256 B6 CZ 295256B6 CZ 20031597 A CZ20031597 A CZ 20031597A CZ 20031597 A CZ20031597 A CZ 20031597A CZ 295256 B6 CZ295256 B6 CZ 295256B6
Authority
CZ
Czechia
Prior art keywords
benzodiazepine
triazolo
imidazo
ethyl
carboxylate
Prior art date
Application number
CZ20031597A
Other languages
Czech (cs)
English (en)
Other versions
CZ20031597A3 (cs
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CZ20031597A3 publication Critical patent/CZ20031597A3/cs
Publication of CZ295256B6 publication Critical patent/CZ295256B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ20031597A 2000-11-16 2001-11-08 Benzodiazepinové deriváty jako modulátory receptoru GABA A CZ295256B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16

Publications (2)

Publication Number Publication Date
CZ20031597A3 CZ20031597A3 (cs) 2003-11-12
CZ295256B6 true CZ295256B6 (cs) 2005-06-15

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20031597A CZ295256B6 (cs) 2000-11-16 2001-11-08 Benzodiazepinové deriváty jako modulátory receptoru GABA A

Country Status (40)

Country Link
US (1) US6743789B2 (https=)
EP (1) EP1337535B1 (https=)
JP (1) JP4088151B2 (https=)
KR (1) KR100504300B1 (https=)
CN (1) CN1191255C (https=)
AR (1) AR031345A1 (https=)
AT (1) ATE268776T1 (https=)
AU (2) AU1700702A (https=)
BG (1) BG107817A (https=)
BR (1) BR0115393A (https=)
CA (1) CA2427576C (https=)
CZ (1) CZ295256B6 (https=)
DE (1) DE60103776T2 (https=)
DK (1) DK1337535T3 (https=)
EC (1) ECSP034607A (https=)
ES (1) ES2220831T3 (https=)
GC (1) GC0000375A (https=)
GT (1) GT200100230A (https=)
HR (1) HRP20030360A2 (https=)
HU (1) HUP0303281A3 (https=)
IL (1) IL155813A0 (https=)
JO (1) JO2359B1 (https=)
MA (1) MA26962A1 (https=)
MX (1) MXPA03004251A (https=)
MY (1) MY141675A (https=)
NO (1) NO324706B1 (https=)
NZ (1) NZ525413A (https=)
PA (1) PA8532401A1 (https=)
PE (1) PE20020583A1 (https=)
PL (1) PL362925A1 (https=)
PT (1) PT1337535E (https=)
RU (1) RU2278865C2 (https=)
SI (1) SI1337535T1 (https=)
SK (1) SK7232003A3 (https=)
TR (1) TR200402073T4 (https=)
TW (1) TWI239333B (https=)
UY (1) UY27026A1 (https=)
WO (1) WO2002040487A2 (https=)
YU (1) YU35603A (https=)
ZA (1) ZA200303435B (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (en) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co METHOD FOR THE SELECTIVE INTRODUCTION OF AN AMINO SUBSTITUENT
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
RU2007112675A (ru) * 2004-10-12 2008-11-20 Ф.Хоффманн-Ля Рош Аг (Ch) ПРОИЗВОДНЫЕ ИМИДАЗО[1,5-a]ТРИАЗОЛО[1,5-d]БЕНЗОДИАЗЕПИНА ДЛЯ ЛЕЧЕНИЯ КОГНИТИВНЫХ РАССТРОЙСТВ
AU2005299031B2 (en) 2004-10-20 2011-11-10 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
MX2007004639A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de imidazo-benzodiazepina.
EP1828194B1 (en) 2004-12-14 2008-05-28 F. Hoffmann-Roche AG Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
EP2682481A3 (en) * 2005-08-03 2014-09-17 The Johns-Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
BRPI0617204A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
RU2510397C2 (ru) 2008-11-18 2014-03-27 Ф. Хоффманн-Ля Рош Аг Алкилциклогексиловые эфиры дигидротетраазабензоазуленов
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
EP3034079B1 (en) 2010-11-15 2018-01-10 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX392119B (es) 2015-06-19 2025-03-11 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
US10059718B2 (en) 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (https=) * 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
US6743789B2 (en) 2004-06-01
DE60103776T2 (de) 2005-07-14
NO20032208D0 (no) 2003-05-15
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
GC0000375A (en) 2007-03-31
BG107817A (bg) 2004-07-30
CA2427576C (en) 2007-11-06
EP1337535B1 (en) 2004-06-09
UY27026A1 (es) 2002-06-20
SI1337535T1 (en) 2004-10-31
JP2004517070A (ja) 2004-06-10
RU2003116895A (ru) 2005-02-20
ZA200303435B (en) 2004-08-05
KR100504300B1 (ko) 2005-07-28
PA8532401A1 (es) 2002-08-26
HRP20030360A2 (en) 2005-04-30
MXPA03004251A (es) 2003-09-22
AU1700702A (en) 2002-05-27
CN1474820A (zh) 2004-02-11
PL362925A1 (en) 2004-11-02
ES2220831T3 (es) 2004-12-16
CA2427576A1 (en) 2002-05-23
DK1337535T3 (da) 2004-10-25
CZ20031597A3 (cs) 2003-11-12
WO2002040487A2 (en) 2002-05-23
ECSP034607A (es) 2003-06-25
MA26962A1 (fr) 2004-12-20
EP1337535A2 (en) 2003-08-27
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
AR031345A1 (es) 2003-09-17
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
PT1337535E (pt) 2004-09-30
RU2278865C2 (ru) 2006-06-27
CN1191255C (zh) 2005-03-02
HK1062442A1 (en) 2004-11-05
HUP0303281A3 (en) 2005-05-30
WO2002040487A3 (en) 2002-09-26
US20020103371A1 (en) 2002-08-01
GT200100230A (es) 2002-07-04
ATE268776T1 (de) 2004-06-15
TWI239333B (en) 2005-09-11
PE20020583A1 (es) 2002-07-06
KR20030045192A (ko) 2003-06-09
MY141675A (en) 2010-06-15
IL155813A0 (en) 2003-12-23
HUP0303281A2 (hu) 2004-01-28
AU2002217007B2 (en) 2006-11-30
NO20032208L (no) 2003-05-15
NO324706B1 (no) 2007-12-03
JP4088151B2 (ja) 2008-05-21
YU35603A (sh) 2006-05-25

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20081108