CZ108099A3 - Použití derivátu kyseliny fumarové - Google Patents

Použití derivátu kyseliny fumarové

Info

Publication number
CZ108099A3
CZ108099A3 CZ991080A CZ108099A CZ108099A3 CZ 108099 A3 CZ108099 A3 CZ 108099A3 CZ 991080 A CZ991080 A CZ 991080A CZ 108099 A CZ108099 A CZ 108099A CZ 108099 A3 CZ108099 A3 CZ 108099A3
Authority
CZ
Czechia
Prior art keywords
fumaric acid
acid derivative
administration
salts
alone
Prior art date
Application number
CZ991080A
Other languages
English (en)
Other versions
CZ299960B6 (cs
Inventor
Kumar Rajendra Dr. Joshi
Hans-Peter Dr. Strebel
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of CZ108099A3 publication Critical patent/CZ108099A3/cs
Publication of CZ299960B6 publication Critical patent/CZ299960B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ0108099A 1997-05-20 1998-04-01 Použití derivátu kyseliny fumarové CZ299960B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19721099A DE19721099C2 (de) 1997-05-20 1997-05-20 Verwendung von Fumarsäurederivaten
PCT/EP1998/001894 WO1998052549A2 (de) 1997-05-20 1998-04-01 Verwendung von fumarsäurederivaten

Publications (2)

Publication Number Publication Date
CZ108099A3 true CZ108099A3 (cs) 1999-08-11
CZ299960B6 CZ299960B6 (cs) 2009-01-07

Family

ID=7829995

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ0108099A CZ299960B6 (cs) 1997-05-20 1998-04-01 Použití derivátu kyseliny fumarové

Country Status (24)

Country Link
US (1) US6436992B1 (cs)
EP (1) EP0980242B1 (cs)
JP (1) JP3881038B2 (cs)
CN (1) CN1153569C (cs)
AT (1) ATE232093T1 (cs)
AU (1) AU730441B2 (cs)
BG (1) BG64613B1 (cs)
BR (1) BR9809655A (cs)
CA (1) CA2248955C (cs)
CZ (1) CZ299960B6 (cs)
DE (2) DE19721099C2 (cs)
DK (1) DK0980242T3 (cs)
EE (1) EE03999B1 (cs)
ES (1) ES2190588T3 (cs)
HU (1) HU227697B1 (cs)
IL (1) IL132819A (cs)
NO (1) NO326815B1 (cs)
NZ (1) NZ501755A (cs)
PL (1) PL190864B1 (cs)
RS (1) RS49654B (cs)
RU (1) RU2197963C2 (cs)
SK (1) SK285897B6 (cs)
TR (1) TR199902587T2 (cs)
WO (1) WO1998052549A2 (cs)

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DE19848260C2 (de) * 1998-10-20 2002-01-17 Fumapharm Ag Muri Fumarsäure-Mikrotabletten
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
PL392748A1 (pl) * 2001-01-12 2011-05-09 Fumapharm Ag Amidy kwasu fumarowego
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
AU2004269903B2 (en) 2003-09-09 2010-09-02 Biogen International Gmbh The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
ME02746B (me) * 2004-10-08 2018-01-20 Forward Pharma As Farmaceutske kompozicije sa kontrolisanim oslobađanjem koje sadrže estar fumarne kiseline
EP1940382A2 (en) * 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
US20070142905A1 (en) * 2005-12-16 2007-06-21 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
WO2007148744A1 (ja) * 2006-06-21 2007-12-27 Santen Pharmaceutical Co., Ltd. フマル酸誘導体を有効成分として含む角結膜障害の予防または治療剤
HUE032251T2 (en) 2007-02-08 2017-09-28 Biogen Ma Inc Neuroprotection in demyelinating diseases
DK2653873T3 (da) 2007-02-08 2022-07-25 Biogen Ma Inc Sammensætninger og anvendelser til behandling af multipel sklerose
US8148414B2 (en) * 2008-08-19 2012-04-03 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
DK2379063T4 (da) 2009-01-09 2021-05-25 Fwp Ip Aps Farmaceutisk præparat omfattende en eller flere fumarsyreestere i en erosionsmatrix
EP3318249A1 (en) 2009-04-29 2018-05-09 Biogen MA Inc. Dimethyl fumarate dosage regimens for the treatment of multiple sclerosis
HRP20151350T1 (hr) * 2010-02-12 2016-01-01 Biogen Ma Inc. Neuroprotekcija kod demijelinizacijskih bolesti
JP2014515373A (ja) * 2011-05-26 2014-06-30 バイオジェン・アイデック・エムエイ・インコーポレイテッド 多発性硬化症の治療方法およびミエリン量を保存および／または増加させる方法
CA2838271A1 (en) 2011-06-08 2012-12-13 Biogen Idec Ma Inc. Process for preparing high purity and crystalline dimethyl fumarate
EP2782561A1 (en) 2011-11-24 2014-10-01 Synthon BV Controlled release particles comprising dimethyl fumarate
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
KR102105217B1 (ko) 2012-02-07 2020-06-01 바이오젠 엠에이 인코포레이티드 다이메틸 푸마레이트를 함유하는 약학 조성물
AU2013203335B2 (en) 2012-02-07 2016-05-26 Xenoport, Inc. Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
US20140056973A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Oral Dosage Forms Having a High Loading of a Methyl Hydrogen Fumarate Prodrug
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US20140171504A1 (en) 2012-12-14 2014-06-19 Georgia Regents Research Institute, Inc. Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters
WO2014100728A1 (en) 2012-12-21 2014-06-26 Biogen Idec Ma Inc. Deuterium substituted fumarate derivatives
CA3081513C (en) 2013-03-14 2022-06-21 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
CN104415026A (zh) * 2013-08-31 2015-03-18 成都渊源生物科技有限公司 氘代富马酸衍生物在治疗多发性硬化症中的应用
JP2016534133A (ja) 2013-09-06 2016-11-04 ゼノポート，インコーポレイティド （ｎ，ｎ−ジエチルカルバモイル）メチル メチル（２ｅ）ブト−２−エン−１，４−ジオエートの結晶形態、その合成方法及び使用
EP3110793B1 (en) 2014-02-24 2019-08-21 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
EP3501510B1 (en) 2014-02-28 2020-07-01 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
DE102014010832A1 (de) 2014-07-24 2016-01-28 Peter Krause Verwendung von medikamentösen Ingredienzien zur Behandlung von Multiple Sklerose
AU2015328676B2 (en) * 2014-10-08 2017-07-20 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
WO2016074684A1 (en) 2014-11-11 2016-05-19 Syddansk Universitet Fumaric acid derivatives for medical use
MA40985A (fr) 2014-11-17 2017-09-26 Biogen Ma Inc Méthodes de traitement de la sclérose en plaques
EP3250198A1 (en) 2014-12-04 2017-12-06 Biogen MA Inc. Multiple sclerosis treatment regimen using dimethyl fumarate
HK1253050A1 (zh) * 2015-02-02 2019-06-06 英仕柏集团有限责任公司 稳定的富马酸二烷基酯组合物
RS62186B1 (sr) 2015-02-08 2021-08-31 Alkermes Pharma Ireland Ltd Kompozicije proleka na bazi monometil fumarata
MA41785A (fr) 2015-03-20 2018-01-23 Biogen Ma Inc Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques
WO2016160635A1 (en) 2015-03-27 2016-10-06 Sytheon Limited Compositions and methods for treating psoriasis
US10213411B2 (en) 2015-08-27 2019-02-26 Vijaykumar Rajasekhar Use of prodrugs of fumarates in treating heart failure diseases
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
US10463642B2 (en) 2016-02-01 2019-11-05 Vijaykumar Rajasekhar Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
US20190029987A1 (en) * 2016-02-12 2019-01-31 Universitat Zurich Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum
CN107973714A (zh) * 2017-12-26 2018-05-01 荆门医药工业技术研究院 一种富马酸单乙酯盐类的制备方法
US11903918B2 (en) 2020-01-10 2024-02-20 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
US20230172894A1 (en) 2020-05-06 2023-06-08 Imcyse Sa Combination treatment for fumarate-related diseases
WO2022132978A1 (en) * 2020-12-18 2022-06-23 Upsher-Smith Laboratories, Llc Modified release solid oral dosage form for once daily administration of monomethyl fumarate

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Also Published As

Publication number Publication date
RS49654B (sr) 2007-09-21
NO991342D0 (no) 1999-03-19
ES2190588T3 (es) 2003-08-01
CA2248955A1 (en) 1997-05-20
JP3881038B2 (ja) 2007-02-14
EP0980242B1 (de) 2003-02-05
BG64613B1 (bg) 2005-09-30
PL190864B1 (pl) 2006-02-28
PL335381A1 (en) 2000-04-25
HUP0001684A3 (en) 2001-09-28
WO1998052549A3 (de) 1999-04-08
DK0980242T3 (da) 2003-04-14
SK41599A3 (en) 2000-12-11
NO326815B1 (no) 2009-02-23
EE9900535A (et) 2000-06-15
HUP0001684A2 (hu) 2000-09-28
HK1027512A1 (en) 2001-01-19
WO1998052549B1 (de) 1999-05-14
CN1257426A (zh) 2000-06-21
HU227697B1 (en) 2011-12-28
TR199902587T2 (xx) 2000-08-21
NO991342L (no) 1999-11-16
RU2197963C2 (ru) 2003-02-10
DE19721099C2 (de) 1999-12-02
EP0980242A2 (de) 2000-02-23
EE03999B1 (et) 2003-04-15
IL132819A0 (en) 2001-03-19
AU730441B2 (en) 2001-03-08
WO1998052549A2 (de) 1998-11-26
AU7213698A (en) 1998-12-11
BR9809655A (pt) 2000-07-11
SK285897B6 (sk) 2007-10-04
NZ501755A (en) 2001-07-27
DE19721099A1 (de) 1998-11-26
JP2000513023A (ja) 2000-10-03
CZ299960B6 (cs) 2009-01-07
ATE232093T1 (de) 2003-02-15
DE59807122D1 (de) 2003-03-13
YU57599A (sh) 2001-12-26
US6436992B1 (en) 2002-08-20
CN1153569C (zh) 2004-06-16
IL132819A (en) 2004-12-15
CA2248955C (en) 2001-08-14
BG103335A (en) 2000-04-28

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20170401