YU58800A - Primena derivata fumarne kiseline u transplantacionoj medicini - Google Patents

Primena derivata fumarne kiseline u transplantacionoj medicini

Info

Publication number
YU58800A
YU58800A YU58800A YU58800A YU58800A YU 58800 A YU58800 A YU 58800A YU 58800 A YU58800 A YU 58800A YU 58800 A YU58800 A YU 58800A YU 58800 A YU58800 A YU 58800A
Authority
YU
Yugoslavia
Prior art keywords
fumaric acid
transplant medicine
acid derivatives
transplant
medicine
Prior art date
Application number
YU58800A
Other languages
English (en)
Inventor
Kumar Rajendra Joshi
Hans-Peter Strebel
Original Assignee
Fumapharm Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag. filed Critical Fumapharm Ag.
Publication of YU58800A publication Critical patent/YU58800A/sh
Publication of RS49780B publication Critical patent/RS49780B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Pronalazak se odnosi na određene monoalkil estre fumarne kiseline kao soli ili slobodne kiseline, samih ili u kombinaciji sa dialkil fumaratom za izradu farmaceutskih pripravaka za primenu u transplatacionoj medicini, naročito za lečenje, ublažavanje ili suzbijanje host-versus-graft reakcija. Monoalkil estri fumarne kiseline mogu u ovom cilju da se primene takođe i u kombinaciji sa uobičajenim preparatima transplantacione medicine i imunosupresivnim sredstvima, kao posebno ciklosporinima.[The invention relates to the use of certain fumaric acid monoalkyl esters in the form of salts or a free acid, alone or combined with a dialkyl fumarate only, for producing pharmaceutical preparations for use in transplant medicine, especially for treating, mitigating or suppressing host-versus-graft reactions. The fumaric acid monoalkyl esters can also be used for this purpose in conjunction with the preparations traditionally used in transplant medicine and with immunosupressants such as cyclosporins in particular.
YUP-588/00A 1998-08-31 1999-08-20 Primena derivata fumarne kiseline u transplantacionoj medicini RS49780B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19839566A DE19839566C2 (de) 1998-08-31 1998-08-31 Verwendung von Fumarsäurederivaten in der Transplantationsmedizin

Publications (2)

Publication Number Publication Date
YU58800A true YU58800A (sh) 2002-03-18
RS49780B RS49780B (sr) 2008-06-05

Family

ID=7879272

Country Status (25)

Country Link
US (1) US6359003B1 (sh)
EP (1) EP1107749B1 (sh)
JP (1) JP3553883B2 (sh)
CN (1) CN1195511C (sh)
AT (1) ATE241353T1 (sh)
AU (1) AU746958B2 (sh)
BG (1) BG64435B1 (sh)
BR (1) BR9908722A (sh)
CA (1) CA2322188C (sh)
DE (2) DE19839566C2 (sh)
DK (1) DK1107749T3 (sh)
EE (1) EE05025B1 (sh)
ES (1) ES2195609T3 (sh)
HK (1) HK1040623B (sh)
HU (1) HUP0101854A3 (sh)
IL (1) IL138110A0 (sh)
NO (1) NO20006462L (sh)
NZ (1) NZ506573A (sh)
PL (1) PL198211B1 (sh)
PT (1) PT1107749E (sh)
RS (1) RS49780B (sh)
RU (1) RU2210364C2 (sh)
SK (1) SK286352B6 (sh)
TR (1) TR200002475T2 (sh)
WO (1) WO2000012072A2 (sh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
ATE447945T1 (de) * 2001-01-12 2009-11-15 Biogen Idec Internat Gmbh Verwendung von fumarsäureamiden
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
AU2003236156A1 (en) * 2003-04-24 2005-01-04 Shin-Jen Shiao Pharmaceutical compositions used for immune disease treatment and improvement
SI1663197T1 (sl) 2003-09-09 2008-06-30 Biogen Idec Internat Gmbh Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
PT2801355E (pt) * 2004-10-08 2015-09-18 Forward Pharma As Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
WO2007006308A1 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use
WO2007006307A2 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
WO2007042035A2 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
WO2007042034A1 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
ES2599227T3 (es) * 2007-02-08 2017-01-31 Biogen Ma Inc. Neuroprotección en enfermedades desmielinizantes
ES2916604T1 (es) 2007-02-08 2022-07-04 Biogen Ma Inc Ensayos de detección de nrf2 y métodos y composiciones relacionados
WO2009078754A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of poorly water soluble pharmaceutically active substances
PL2334378T3 (pl) 2008-08-19 2014-09-30 Xenoport Inc Proleki wodorofumaranu metylu, ich kompozycje farmaceutyczne i sposoby zastosowania
EP2564839B1 (en) 2009-01-09 2016-05-11 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
PL2718257T3 (pl) 2011-06-08 2018-04-30 Biogen Ma Inc. Sposób przygotowywania dimetylofumaranu krystalicznego o wysokiej czystości
CN103826624A (zh) * 2011-08-30 2014-05-28 富山化学工业株式会社 类风湿性关节炎等自身免疫疾病的处置的改善方法
EP2782561A1 (en) 2011-11-24 2014-10-01 Synthon BV Controlled release particles comprising dimethyl fumarate
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
CN114146079A (zh) 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
MX2014009511A (es) 2012-02-07 2014-10-24 Xenoport Inc Compuestos de fumarato de morfolinoalquilo, composiciones farmaceuticas y metodos de uso.
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US20140057918A1 (en) * 2012-08-22 2014-02-27 Xenoport, Inc. Methods of Use for Monomethyl Fumarate and Prodrugs Thereof
JP2015526477A (ja) 2012-08-22 2015-09-10 ゼノポート，インコーポレイティド メチル水素フマレートの経口剤形およびそのプロドラッグ
CN103483194B (zh) * 2012-11-30 2016-03-09 杨寅柯 一种2-氟代富马酸酯(结构式i)及其制备方法及应用
AR094277A1 (es) 2012-12-21 2015-07-22 Biogen Idec Inc Derivados de fumarato sustituidos con deuterio
SG11201507371RA (en) 2013-03-14 2015-10-29 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various deseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
EA037666B1 (ru) * 2015-02-08 2021-04-28 Алкермес Фарма Айрленд Лимитед Фармацевтическая композиция, содержащая 2-(2,5-диоксопирролидин-1-ил)этилметилфумарат, и ее применение в медицине
WO2016160635A1 (en) 2015-03-27 2016-10-06 Sytheon Limited Compositions and methods for treating psoriasis
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
CN106265621B (zh) * 2016-09-19 2019-05-17 苏州大学 富马酸二甲酯在制备预防和治疗移植物抗宿主病及移植物抗白血病药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530372A1 (de) * 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2621214C3 (de) * 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
US5149695A (en) * 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
CH664150A5 (de) * 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) * 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US6011000A (en) 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
AU3889197A (en) 1996-07-26 1998-02-20 Douglas V Faller Compositions comprising an inducing agent and an anti-viral agent for the treat ment of blood, viral and cellular disorders
AU5474198A (en) * 1996-12-24 1998-07-17 National Research Council Of Canada Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals
DE19721099C2 (de) * 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
DE19814358C2 (de) * 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn

Also Published As

Publication number Publication date
HK1040623B (zh) 2005-08-19
HK1040623A1 (en) 2002-06-21
HUP0101854A3 (en) 2003-04-28
HUP0101854A2 (hu) 2001-11-28
PL198211B1 (pl) 2008-06-30
JP3553883B2 (ja) 2004-08-11
SK286352B6 (en) 2008-07-07
EE200000654A (et) 2002-04-15
DE19839566C2 (de) 2002-01-17
US6359003B1 (en) 2002-03-19
DK1107749T3 (da) 2003-08-18
BR9908722A (pt) 2001-10-16
JP2002525276A (ja) 2002-08-13
BG64435B1 (en) 2005-02-28
ES2195609T3 (es) 2003-12-01
NZ506573A (en) 2002-10-25
RU2210364C2 (ru) 2003-08-20
WO2000012072A3 (de) 2000-05-04
PL347359A1 (en) 2002-04-08
EP1107749A2 (de) 2001-06-20
NO20006462L (no) 2001-04-30
BG104679A (en) 2001-02-28
AU5737899A (en) 2000-03-21
ATE241353T1 (de) 2003-06-15
CN1316901A (zh) 2001-10-10
CA2322188C (en) 2004-03-09
IL138110A0 (en) 2001-10-31
NO20006462D0 (no) 2000-12-18
EE05025B1 (et) 2008-06-16
WO2000012072A2 (de) 2000-03-09
AU746958B2 (en) 2002-05-09
TR200002475T2 (tr) 2001-03-21
CN1195511C (zh) 2005-04-06
DE19839566A1 (de) 2000-03-09
PT1107749E (pt) 2003-08-29
DE59905763D1 (de) 2003-07-03
SK2572001A3 (en) 2002-05-09
CA2322188A1 (en) 2000-03-09
EP1107749B1 (de) 2003-05-28
RS49780B (sr) 2008-06-05

Similar Documents

Publication Publication Date Title
YU58800A (sh) Primena derivata fumarne kiseline u transplantacionoj medicini
CA2248955A1 (en) The use of fumaric acid derivatives
TR200102648T2 (tr) Büyümeyi destekleyen bileşimler
AU3435497A (en) Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies
HUS1400034I1 (hu) Dialkil-fumarátok alkalmazása autoimmun betegségek kezelésére szolgáló gyógyászati készítmények elõállítására
AU5404399A (en) Topical application products
UA89035C2 (ru) Эфиры гидроксамовых кислот и их фармацевтическое применение
AU5916998A (en) Non-irritating composition for treating acne and other skin conditions
AU3850600A (en) Dalda analogs and their use
IL150487A0 (en) Methods and compositions for mitigating pain using nitrate esters
HK1047707A1 (zh) (+)-曲馬朵、o-去甲曲馬朵或(+)-o-去甲曲馬朵、o-去甲-n-單-去甲-曲馬朵或(+)-o-去甲-n-單-去甲-曲馬朵治療尿失禁的用途
IL134259A0 (en) Use of physiologically acceptable vanadium compounds, salts and complexes
IL126235A (en) Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
DE50100833D1 (de) Verwendung von 2-methyl-thiazolidin-2,4-dicarbonsäure und / oder ihrer physiologisch verträglichen salze zur herstellung eines medikaments zur behandlung von krebserkrankungen
EP1152762B8 (de) Verwendung von desoxypeganin zur behandlung von alzheimerischer demenz
EP0743068A3 (en) Composition for inhibiting bone loss containing vanadyl sulfate
YU19302A (sh) 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena
YU30602A (sh) Primena 2-amino-3,4-dihidro-hinazolina za proizvodnju leka za lečenje ili profilaksu bolesti koje su prouzrokovane ishemičnim stanjima
DE69512522D1 (de) Antimessenger oligonukleotide und urokinaserezeptor umkehrung des invasive phänotyps transformieter menschlicher fibroblasten durch antimessenger oligonukleotidinhibierung von urokinaserezeptoren-expression
WO2002012336A3 (en) TGF-β THERAPEUTICS, COMPOSITIONS AND METHODS OF USE
ATE306273T1 (de) Verwendung von tiludronsäure beim geflügel zur herstellung eines arzneimittels zur prophylaxe und behandlung von osteoporose
UA36167A (uk) Спосіб лікування панкреатиту