EE05025B1 - Fumaarhappe derivaadid kasutamiseks transplantaadivastase reaktsiooni raviks - Google Patents

Fumaarhappe derivaadid kasutamiseks transplantaadivastase reaktsiooni raviks

Info

Publication number
EE05025B1
EE05025B1 EEP200000654A EEP200000654A EE05025B1 EE 05025 B1 EE05025 B1 EE 05025B1 EE P200000654 A EEP200000654 A EE P200000654A EE P200000654 A EEP200000654 A EE P200000654A EE 05025 B1 EE05025 B1 EE 05025B1
Authority
EE
Estonia
Prior art keywords
fumaric acid
treatment
acid derivatives
graft reaction
combination
Prior art date
Application number
EEP200000654A
Other languages
English (en)
Estonian (et)
Inventor
Kumar Joshi Rajendra
Strebel Hans-Peter
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of EE200000654A publication Critical patent/EE200000654A/xx
Publication of EE05025B1 publication Critical patent/EE05025B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EEP200000654A 1998-08-31 1999-08-20 Fumaarhappe derivaadid kasutamiseks transplantaadivastase reaktsiooni raviks EE05025B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19839566A DE19839566C2 (de) 1998-08-31 1998-08-31 Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
PCT/EP1999/006110 WO2000012072A2 (de) 1998-08-31 1999-08-20 Verwendung von fumarsäurederivaten in der transplantationsmedizin

Publications (2)

Publication Number Publication Date
EE200000654A EE200000654A (et) 2002-04-15
EE05025B1 true EE05025B1 (et) 2008-06-16

Family

ID=7879272

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000654A EE05025B1 (et) 1998-08-31 1999-08-20 Fumaarhappe derivaadid kasutamiseks transplantaadivastase reaktsiooni raviks

Country Status (25)

Country Link
US (1) US6359003B1 (xx)
EP (1) EP1107749B1 (xx)
JP (1) JP3553883B2 (xx)
CN (1) CN1195511C (xx)
AT (1) ATE241353T1 (xx)
AU (1) AU746958B2 (xx)
BG (1) BG64435B1 (xx)
BR (1) BR9908722A (xx)
CA (1) CA2322188C (xx)
DE (2) DE19839566C2 (xx)
DK (1) DK1107749T3 (xx)
EE (1) EE05025B1 (xx)
ES (1) ES2195609T3 (xx)
HK (1) HK1040623B (xx)
HU (1) HUP0101854A3 (xx)
IL (1) IL138110A0 (xx)
NO (1) NO20006462L (xx)
NZ (1) NZ506573A (xx)
PL (1) PL198211B1 (xx)
PT (1) PT1107749E (xx)
RS (1) RS49780B (xx)
RU (1) RU2210364C2 (xx)
SK (1) SK286352B6 (xx)
TR (1) TR200002475T2 (xx)
WO (1) WO2000012072A2 (xx)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
WO2002055063A2 (de) * 2001-01-12 2002-07-18 Fumapharm Ag Fumarsäureamide
DE10217314A1 (de) * 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
AU2003236156A1 (en) * 2003-04-24 2005-01-04 Shin-Jen Shiao Pharmaceutical compositions used for immune disease treatment and improvement
AU2004269903B2 (en) * 2003-09-09 2010-09-02 Biogen International Gmbh The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
US20140099364A2 (en) * 2004-10-08 2014-04-10 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
US20080227847A1 (en) * 2005-07-07 2008-09-18 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
ATE455783T1 (de) * 2005-07-07 2010-02-15 Aditech Pharma Ag Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung
WO2007042035A2 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
US20080299196A1 (en) * 2005-10-07 2008-12-04 Aditech Pharma Ab Controlled Release Pharmaceutical Compositions Comprising a Fumaric Acid Ester
US20100130607A1 (en) * 2007-02-08 2010-05-27 Ralf Gold Neuroprotection in demyelinating diseases
ES2916649T3 (es) 2007-02-08 2022-09-21 Biogen Ma Inc Composiciones y usos para el tratamiento de la esclerosis múltiple
WO2009078754A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of poorly water soluble pharmaceutically active substances
EP2650279A3 (en) 2008-08-19 2014-02-12 XenoPort, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
PT2379063E (pt) 2009-01-09 2013-05-03 Forward Pharma As Formulação farmacêutica compreendendo um ou mais ésteres de ácido fumárico numa matriz de erosão
CN103649041A (zh) 2011-06-08 2014-03-19 比奥根艾迪克Ma公司 制备高纯度和结晶的富马酸二甲酯的方法
KR101722432B1 (ko) * 2011-08-30 2017-04-04 토야마 케미칼 컴퍼니 리미티드 류마티스성 관절염 등 자가면역 질환 치료의 개선방법
EP2782561A1 (en) 2011-11-24 2014-10-01 Synthon BV Controlled release particles comprising dimethyl fumarate
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
CN114146080A (zh) * 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
US8952006B2 (en) 2012-02-07 2015-02-10 Xenoport, Inc. Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US20140057918A1 (en) * 2012-08-22 2014-02-27 Xenoport, Inc. Methods of Use for Monomethyl Fumarate and Prodrugs Thereof
WO2014031844A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
CN103483194B (zh) * 2012-11-30 2016-03-09 杨寅柯 一种2-氟代富马酸酯(结构式i)及其制备方法及应用
JP6506174B2 (ja) 2012-12-21 2019-04-24 バイオジェン エムエー インコーポレイテッド 重水素置換されたフマル酸誘導体
RS57497B1 (sr) 2013-03-14 2018-10-31 Alkermes Pharma Ireland Ltd Prolekovi fumarata i njihova upotreba u lečenju raznih bolesti
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
EP3110793B1 (en) 2014-02-24 2019-08-21 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
EA037666B1 (ru) * 2015-02-08 2021-04-28 Алкермес Фарма Айрленд Лимитед Фармацевтическая композиция, содержащая 2-(2,5-диоксопирролидин-1-ил)этилметилфумарат, и ее применение в медицине
US9636321B2 (en) 2015-03-27 2017-05-02 Symbionyx Pharmaceuticals Inc. Compositions and methods for treating psoriasis
WO2017060400A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of disesases related to mitochondrial dysfunctions
CN106265621B (zh) * 2016-09-19 2019-05-17 苏州大学 富马酸二甲酯在制备预防和治疗移植物抗宿主病及移植物抗白血病药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530372A1 (de) * 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2621214C3 (de) * 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
US5149695A (en) * 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
CH664150A5 (de) * 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) * 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US6011000A (en) * 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
JP2001527517A (ja) * 1996-07-26 2001-12-25 スーザン・ピー・ペリーネ 血液、ウイルス性および細胞性疾患の治療組成物
WO1998027970A2 (en) 1996-12-24 1998-07-02 National Research Council Of Canada Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals
DE19721099C2 (de) * 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
DE19814358C2 (de) * 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn

Also Published As

Publication number Publication date
HUP0101854A3 (en) 2003-04-28
JP2002525276A (ja) 2002-08-13
AU746958B2 (en) 2002-05-09
CN1316901A (zh) 2001-10-10
DE19839566C2 (de) 2002-01-17
CN1195511C (zh) 2005-04-06
AU5737899A (en) 2000-03-21
RU2210364C2 (ru) 2003-08-20
EP1107749B1 (de) 2003-05-28
IL138110A0 (en) 2001-10-31
EP1107749A2 (de) 2001-06-20
NZ506573A (en) 2002-10-25
WO2000012072A3 (de) 2000-05-04
DE19839566A1 (de) 2000-03-09
ES2195609T3 (es) 2003-12-01
HUP0101854A2 (hu) 2001-11-28
DK1107749T3 (da) 2003-08-18
WO2000012072A2 (de) 2000-03-09
BG64435B1 (en) 2005-02-28
PL198211B1 (pl) 2008-06-30
RS49780B (sr) 2008-06-05
SK286352B6 (en) 2008-07-07
HK1040623A1 (en) 2002-06-21
CA2322188C (en) 2004-03-09
DE59905763D1 (de) 2003-07-03
CA2322188A1 (en) 2000-03-09
NO20006462L (no) 2001-04-30
BR9908722A (pt) 2001-10-16
BG104679A (en) 2001-02-28
TR200002475T2 (tr) 2001-03-21
HK1040623B (zh) 2005-08-19
ATE241353T1 (de) 2003-06-15
JP3553883B2 (ja) 2004-08-11
YU58800A (sh) 2002-03-18
PL347359A1 (en) 2002-04-08
US6359003B1 (en) 2002-03-19
EE200000654A (et) 2002-04-15
SK2572001A3 (en) 2002-05-09
NO20006462D0 (no) 2000-12-18
PT1107749E (pt) 2003-08-29

Similar Documents

Publication Publication Date Title
EE05025B1 (et) Fumaarhappe derivaadid kasutamiseks transplantaadivastase reaktsiooni raviks
NO308794B1 (no) Farmakologisk aktive pyridin-derivater, preparater inneholdende forbindelsene samt forbindelsenes anvendelse
ATE242633T1 (de) Dialkylfumarate zur behandlung von autoimmunerkrankungen
TR200102648T2 (tr) Büyümeyi destekleyen bileşimler
CA2248955A1 (en) The use of fumaric acid derivatives
DE69229442T2 (de) Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung
ATE55695T1 (de) Verwendung von defibrotid zur herstellung pharmazeutischer zusammensetzungen zur behandlung peripherer arteriopathien.
ES2160643T3 (es) Composiciones que contienen g-csf y proteina de union al tnf.
ES2106531T3 (es) Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
ATE330590T1 (de) Pharmazeutische zusammensetzungen enthaltend tetrac sowie deren verwendungsverfahren
IL126235A (en) Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
DE60230155D1 (de) Verwendung von verzweigtkettigen fettsäuren und ihrer derivate zur schmerzbehandlung
ATE90563T1 (de) Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie.
DE50100833D1 (de) Verwendung von 2-methyl-thiazolidin-2,4-dicarbonsäure und / oder ihrer physiologisch verträglichen salze zur herstellung eines medikaments zur behandlung von krebserkrankungen
DE69314586T2 (de) Arzneimittelzusammensetzung enthaltend TCF-II
HUP9904578A2 (hu) Xanomelin alkalmazása bipoláris depresszió kezelésére szolgáló gyógyszerkészítmények előállítására

Legal Events

Date Code Title Description
HE1A Change of address
KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090820