ES2190588T3 - Uso de derivados de acido fumarico para el tratamiento de enfermedades autoinmunes. - Google Patents

Uso de derivados de acido fumarico para el tratamiento de enfermedades autoinmunes.

Info

Publication number
ES2190588T3
ES2190588T3 ES98919202T ES98919202T ES2190588T3 ES 2190588 T3 ES2190588 T3 ES 2190588T3 ES 98919202 T ES98919202 T ES 98919202T ES 98919202 T ES98919202 T ES 98919202T ES 2190588 T3 ES2190588 T3 ES 2190588T3
Authority
ES
Spain
Prior art keywords
fumaric acid
treatment
acid derivatives
autoimmune diseases
polyarthritis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98919202T
Other languages
English (en)
Inventor
Rajendra K Joshi
Hans-Peter Strebel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen International GmbH
Original Assignee
Fumapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm AG filed Critical Fumapharm AG
Application granted granted Critical
Publication of ES2190588T3 publication Critical patent/ES2190588T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a la utilización de ciertos monoalquilésteres de ácido fumárico, como sales o ácidos libres, solos o en asociación con un fumarato de dialquilo para la producción de preparaciones farmacéuticas destinadas a tratar la poliartritis o la esclerosis múltiple, así como las reacciones de injerto contra huésped.
ES98919202T 1997-05-20 1998-04-01 Uso de derivados de acido fumarico para el tratamiento de enfermedades autoinmunes. Expired - Lifetime ES2190588T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19721099A DE19721099C2 (de) 1997-05-20 1997-05-20 Verwendung von Fumarsäurederivaten

Publications (1)

Publication Number Publication Date
ES2190588T3 true ES2190588T3 (es) 2003-08-01

Family

ID=7829995

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98919202T Expired - Lifetime ES2190588T3 (es) 1997-05-20 1998-04-01 Uso de derivados de acido fumarico para el tratamiento de enfermedades autoinmunes.

Country Status (25)

Country Link
US (1) US6436992B1 (es)
EP (1) EP0980242B1 (es)
JP (1) JP3881038B2 (es)
CN (1) CN1153569C (es)
AT (1) ATE232093T1 (es)
AU (1) AU730441B2 (es)
BG (1) BG64613B1 (es)
BR (1) BR9809655A (es)
CA (1) CA2248955C (es)
CZ (1) CZ299960B6 (es)
DE (2) DE19721099C2 (es)
DK (1) DK0980242T3 (es)
EE (1) EE03999B1 (es)
ES (1) ES2190588T3 (es)
HK (1) HK1027512A1 (es)
HU (1) HU227697B1 (es)
IL (1) IL132819A (es)
NO (1) NO326815B1 (es)
NZ (1) NZ501755A (es)
PL (1) PL190864B1 (es)
RS (1) RS49654B (es)
RU (1) RU2197963C2 (es)
SK (1) SK285897B6 (es)
TR (1) TR199902587T2 (es)
WO (1) WO1998052549A2 (es)

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DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
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DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
DE10217314A1 (de) * 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
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RU2743637C2 (ru) 2009-01-09 2021-02-20 Фвп Ип Апс Фармацевтический состав, содержащий один или более эфиров фумаровой кислоты в разлагаемой матрице
CA2760133A1 (en) 2009-04-29 2010-11-04 Biogen Idec Ma Inc. Treatment of neurodegeneration and neuroinflammation
ME02317B (me) * 2010-02-12 2016-06-20 Biogen Ma Inc Neuroprotekcija kod demijelinizacijskih bolesti
PE20141316A1 (es) * 2011-05-26 2014-10-01 Biogen Idec Inc Metodos para tratar la esclerosis multiple y preservar y/o aumentar el contenido de mielina
RS56972B1 (sr) 2011-06-08 2018-05-31 Biogen Ma Inc Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata
EP2782561A1 (en) 2011-11-24 2014-10-01 Synthon BV Controlled release particles comprising dimethyl fumarate
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
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AU2013203445C1 (en) 2012-02-07 2017-04-20 Biogen Ma Inc. Pharmaceutical compositions containing dimethyl fumarate
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US20140171504A1 (en) 2012-12-14 2014-06-19 Georgia Regents Research Institute, Inc. Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters
ES2733961T3 (es) 2012-12-21 2019-12-03 Biogen Ma Inc Derivados de fumarato sustituidos con deuterio
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
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WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
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CN107847451A (zh) * 2015-02-02 2018-03-27 英仕柏集团有限责任公司 稳定的富马酸二烷基酯组合物
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Also Published As

Publication number Publication date
YU57599A (sh) 2001-12-26
PL335381A1 (en) 2000-04-25
JP3881038B2 (ja) 2007-02-14
BR9809655A (pt) 2000-07-11
BG103335A (en) 2000-04-28
CZ108099A3 (cs) 1999-08-11
WO1998052549A3 (de) 1999-04-08
RS49654B (sr) 2007-09-21
ATE232093T1 (de) 2003-02-15
HUP0001684A2 (hu) 2000-09-28
EE03999B1 (et) 2003-04-15
EP0980242A2 (de) 2000-02-23
SK41599A3 (en) 2000-12-11
HUP0001684A3 (en) 2001-09-28
JP2000513023A (ja) 2000-10-03
DK0980242T3 (da) 2003-04-14
HU227697B1 (en) 2011-12-28
RU2197963C2 (ru) 2003-02-10
DE19721099A1 (de) 1998-11-26
EP0980242B1 (de) 2003-02-05
CN1257426A (zh) 2000-06-21
CZ299960B6 (cs) 2009-01-07
NO326815B1 (no) 2009-02-23
IL132819A0 (en) 2001-03-19
AU7213698A (en) 1998-12-11
IL132819A (en) 2004-12-15
SK285897B6 (sk) 2007-10-04
PL190864B1 (pl) 2006-02-28
CA2248955A1 (en) 1997-05-20
NO991342L (no) 1999-11-16
HK1027512A1 (en) 2001-01-19
WO1998052549A2 (de) 1998-11-26
CA2248955C (en) 2001-08-14
US6436992B1 (en) 2002-08-20
DE59807122D1 (de) 2003-03-13
CN1153569C (zh) 2004-06-16
NO991342D0 (no) 1999-03-19
DE19721099C2 (de) 1999-12-02
BG64613B1 (bg) 2005-09-30
NZ501755A (en) 2001-07-27
EE9900535A (et) 2000-06-15
TR199902587T2 (xx) 2000-08-21
WO1998052549B1 (de) 1999-05-14
AU730441B2 (en) 2001-03-08

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