CY1121841T1 - Τοπικη αντιμυκητιασικη συνθεση για τη θεραπεια της ονυχομυκητιασης - Google Patents

Τοπικη αντιμυκητιασικη συνθεση για τη θεραπεια της ονυχομυκητιασης

Info

Publication number
CY1121841T1
CY1121841T1 CY20191100804T CY191100804T CY1121841T1 CY 1121841 T1 CY1121841 T1 CY 1121841T1 CY 20191100804 T CY20191100804 T CY 20191100804T CY 191100804 T CY191100804 T CY 191100804T CY 1121841 T1 CY1121841 T1 CY 1121841T1
Authority
CY
Cyprus
Prior art keywords
treatment
onychomycitis
antifungal composition
topical antifungal
relates
Prior art date
Application number
CY20191100804T
Other languages
English (en)
Inventor
Federico Mailland
Michela Legora
Daniela Ceriani
Giuliana Iob
Original Assignee
Polichem S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50029007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121841(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem S.A. filed Critical Polichem S.A.
Publication of CY1121841T1 publication Critical patent/CY1121841T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μια λάκα νυχιών που αποτελείται ουσιαστικά από τερβιναφίνη ως αντιμυκητιακό παράγοντα, υδροξυπροπυλική χιτοζάνη ως παράγοντα σχηματισμού υμενίου, νερό και μια κατώτερη αλκανόλη ως διαλύτες. Η εφεύρεση αφορά επίσης μια μέθοδο για τη θεραπεία της ονυχομυκητίασης μέσω τοπικής χορήγησης, όπως μια λάκα νυχιών, σε έναν ασθενή που χρήζει τέτοιας θεραπείας.
CY20191100804T 2013-02-07 2019-07-29 Τοπικη αντιμυκητιασικη συνθεση για τη θεραπεια της ονυχομυκητιασης CY1121841T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361761953P 2013-02-07 2013-02-07
US201361781560P 2013-03-14 2013-03-14
PCT/EP2014/051288 WO2014122024A1 (en) 2013-02-07 2014-01-23 Topical antifungal composition for treating onychomycosis

Publications (1)

Publication Number Publication Date
CY1121841T1 true CY1121841T1 (el) 2020-07-31

Family

ID=50029007

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100804T CY1121841T1 (el) 2013-02-07 2019-07-29 Τοπικη αντιμυκητιασικη συνθεση για τη θεραπεια της ονυχομυκητιασης

Country Status (35)

Country Link
US (3) US8697753B1 (el)
EP (1) EP2953621B1 (el)
JP (1) JP6420258B2 (el)
KR (1) KR102200788B1 (el)
CN (1) CN105050592B (el)
AU (1) AU2014214166B2 (el)
BR (1) BR112015018798B1 (el)
CA (1) CA2900127C (el)
CL (1) CL2015002191A1 (el)
CR (1) CR20150377A (el)
CY (1) CY1121841T1 (el)
DK (1) DK2953621T3 (el)
EA (1) EA036061B1 (el)
EC (1) ECSP15033898A (el)
ES (1) ES2729373T3 (el)
HK (1) HK1212904A1 (el)
HR (1) HRP20191243T1 (el)
HU (1) HUE045000T2 (el)
IL (1) IL240334B (el)
LT (1) LT2953621T (el)
ME (1) ME03507B (el)
MX (1) MX361880B (el)
NZ (1) NZ709668A (el)
PE (1) PE20151300A1 (el)
PH (1) PH12015501739B1 (el)
PL (1) PL2953621T3 (el)
PT (1) PT2953621T (el)
RS (1) RS58990B1 (el)
SG (1) SG11201505275YA (el)
SI (1) SI2953621T1 (el)
TN (1) TN2015000316A1 (el)
TW (1) TWI658839B (el)
UY (1) UY35307A (el)
WO (1) WO2014122024A1 (el)
ZA (1) ZA201504880B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
KR101580077B1 (ko) * 2015-03-28 2015-12-24 한국콜마주식회사 시크로피록스 함유 네일락카 조성물
GB201605127D0 (en) * 2016-03-25 2016-05-11 Blueberry Therapeutics Ltd Composition and methods of treatment
DE102019003486B4 (de) * 2019-05-17 2021-03-18 L/N Health And Beauty Aps Zusammensetzungen zur Behandlung der Onychomykose
WO2021127107A1 (en) * 2019-12-20 2021-06-24 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Topical pharmaceutical compositions for treating onychomycosis

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883545A (en) 1968-08-31 1975-05-13 Hoechst Ag Certain 1-hydroxy-2-pyridones
AT354187B (de) 1976-11-22 1979-12-27 Hoffmann La Roche Fungizides mittel
DE19975055I1 (de) 1979-08-22 2000-01-27 Novartis Ag Propenylamine Verfahren zu ihrer Herstellung sie enthaltende pharmazeutische Zusammensetzungen und ihre Verwending als Arzneimittel
DE3045914A1 (de) 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3045915A1 (de) 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3245784A1 (de) 1982-12-10 1984-06-14 Wella Ag, 6100 Darmstadt Kosmetisches mittel auf der basis von quaternaeren chitosanderivaten, neue quaternaere chitosanderivate sowie verfahren zu ihrer herstellung
DE3502833A1 (de) 1985-01-29 1986-07-31 Wella Ag, 6100 Darmstadt Kosmetische mittel auf der basis von quaternaeren chitosanderivaten, neue quaternaere hydroxyethyl-substituierte chitosanderivate sowie verfahren zu ihrer herstellung
DE3513277A1 (de) 1985-04-13 1986-10-23 Wella Ag, 6100 Darmstadt Kosmetische mittel auf der basis von quaternaeren hydroxyalkyl-substituierten chitosanderivaten
EP0247142B1 (en) 1985-11-04 1993-01-07 Owen/Galderma Laboratories Inc. Film-forming, pharmaceutical vehicles for application of medicaments to nails, pharmaceutical compositions based on those vehicles, and methods of using same
DE3541305A1 (de) 1985-11-22 1987-05-27 Wella Ag Kosmetische mittel auf der basis von n-hydroxypropylchitosanen, neue n-hydroxypropyl-chitosane sowie verfahren zu ihrer herstellung
DE3544983A1 (de) 1985-12-19 1987-06-25 Hoechst Ag Antimykotisch wirksamer nagellack
DE3545929A1 (de) 1985-12-23 1987-06-25 Ceag Licht & Strom Gehaeuse
SE460713B (sv) 1986-04-22 1989-11-13 Atlas Copco Ab Hydrauliskt momentimpulsverk
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
DE3703760A1 (de) 1987-02-07 1988-08-18 Wella Ag Kosmetisches mittel auf der basis von n-hydroxypropylisopropyletherchitosanen, sowie neue n-hydroxypropylisopropyletherderivate des chitosans
HU200914B (en) 1987-03-09 1990-09-28 Horvath Gyoengyi Lengyelne Process for producing new medical dosage unit suitable for local treatment of fungus infection of nails
DE3720147A1 (de) 1987-06-16 1988-12-29 Hoechst Ag Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
DE3723811A1 (de) 1987-07-18 1989-01-26 Wella Ag Nagellack auf der basis von o-benzyl-n-hydroxyalkylchitosanen sowie neue o-benzyl-n-hydroxyalkylderivate des chitosans
CA2008775C (en) 1989-02-24 1998-12-22 Alberto Ferro Nail lacquer
FR2673537B1 (fr) 1991-03-08 1993-06-11 Oreal Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.
DE4108664C2 (de) 1991-03-16 1995-03-09 Scheller Cosmetics Gmbh Dr Nagellack und Verwendung desselben
HU223343B1 (hu) 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
DE4212105A1 (de) 1992-04-10 1993-10-14 Roehm Pharma Gmbh Nagellack zur Behandlung von Onychomykosen
JPH05339152A (ja) 1992-06-09 1993-12-21 Nippon Soda Co Ltd 皮膚病変局所投与薬剤含有キトサン誘導体フィルム剤
JPH06211651A (ja) 1993-01-12 1994-08-02 Hisamitsu Pharmaceut Co Inc 爪白癬治療用組成物
DE19518262A1 (de) 1995-05-18 1996-11-21 Hoechst Ag Die Verwendung von Glyceryltriacetat zur Behandlung von Onychomykosen
US5391367A (en) 1993-07-28 1995-02-21 Pfizer Inc. Antifungal nail solution
US5487776A (en) 1994-03-17 1996-01-30 Nimni; Marcel Anti-fungal nail lacquer and method therefor
WO1996011710A1 (fr) 1994-10-13 1996-04-25 Hisamitsu Pharmaceutical Co., Inc. Preparation externe pour onychomycose
JP2951725B2 (ja) 1994-10-13 1999-09-20 久光製薬株式会社 爪白癬用外用組成物
US5696164A (en) 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
DE19503423A1 (de) 1995-02-03 1996-08-08 Beiersdorf Ag Antiadhäsive Wirkstoffe
JPH11501911A (ja) 1995-03-03 1999-02-16 ビー マーゴリン、ソロモン サイトカイン成長因子の引き起こす疾病の治療
DE19604190A1 (de) 1996-02-06 1997-08-07 Hoechst Ag Nagelwachstumsfördernde Zubereitungen
EP0863981B1 (en) 1996-08-01 2009-09-23 Dale Wallis Detection, prevention and treatment of papillomatous digital dermatitis
JP4253047B2 (ja) 1996-09-27 2009-04-08 杏林製薬株式会社 被膜形成性抗真菌剤組成物
JP4227677B2 (ja) 1996-12-10 2009-02-18 杏林製薬株式会社 被膜形成性抗真菌剤組成物
FR2761886B1 (fr) 1997-04-14 2000-05-05 Virbac Sa Compositions contenant au moins un polymere cationique et au moins une molecule active contenue dans au moins un vecteur micro ou nanoparticulaire, et leur utilisation pour le traitement de surfaces vivantes ou inertes
US5991438A (en) 1997-07-31 1999-11-23 Hewlett-Packard Company Color halftone error-diffusion with local brightness variation reduction
EP0983037B1 (en) 1998-02-09 2003-05-02 MacroChem Corporation Antifungal nail lacquer
AU755003B2 (en) 1998-03-17 2002-11-28 Solomon B. Margolin Topical antiseptic compositions and methods
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
ATE269067T1 (de) 1998-04-17 2004-07-15 Bertek Pharm Inc Topische formulierungen zur behandlung von nagel pilzerkrankungen
US6306375B1 (en) 1998-05-01 2001-10-23 The Procter & Gamble Company Long wear nail polish having defined surface properties
US5965111A (en) 1998-05-01 1999-10-12 The Procter & Gamble Company Fast drying water-borne nail polish
US6284234B1 (en) 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
EP1143950B1 (de) 1998-09-10 2005-03-09 BioEqual AG Topisch anwendbare mittel gegen nagelpilzerkrankungen
DE19841796A1 (de) 1998-09-12 2000-03-16 Beiersdorf Ag Kombinationen von Antiadhäsiva (Kohlenhydrate) und Mikrobiziden
US6159977A (en) 1998-11-16 2000-12-12 Astan, Inc. Therapeutic anti-fungal nail preparation
ATE249811T1 (de) 1999-02-09 2003-10-15 Cognis Deutschland Gmbh Verwendung von nanoskaligen chitosanen
AU3930200A (en) 1999-08-19 2001-03-19 Lavipharm S.A. Film forming polymers, methods of use, and devices and applications thereof
DE19960632A1 (de) 1999-12-16 2001-07-05 Cognis Deutschland Gmbh Kosmetische Mittel enthaltend natürliche Chitosane
DE50012415D1 (de) 2000-01-03 2006-05-11 Karl Kraemer Zubereitungen zur atraumatischen nagelentfernung
KR20030016227A (ko) 2000-02-16 2003-02-26 벤트레이 파마슈티칼스, 인코포레이티드 약학적 조성물
DE10011081A1 (de) 2000-03-09 2001-09-13 Aventis Pharma Gmbh Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel
US7074392B1 (en) 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
DE10035991A1 (de) 2000-07-24 2002-02-14 Polichem Sa Nagellackzusammensetzung
GB0019283D0 (en) 2000-08-04 2000-09-27 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
US6676953B2 (en) 2001-01-26 2004-01-13 Don L. Hexamer Antifungal composition and method for human nails
US20030118655A1 (en) 2001-12-21 2003-06-26 Nikhil Kundel Film forming liquid composition
US6921529B2 (en) 2002-07-29 2005-07-26 Joseph C. Maley Treatment modality and method for fungal nail infection
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
ATE432087T1 (de) 2003-03-21 2009-06-15 Nexmed Holdings Inc Antimykotischer nagellack und anwendungsverfahren
EP1491202A1 (en) 2003-06-23 2004-12-29 Polichem S.A. Nail restructuring compositions for topical application
US20060280703A1 (en) 2003-07-29 2006-12-14 Pascal Lefrancois Antimycotic nail varnish
AR045241A1 (es) 2003-08-12 2005-10-19 Novartis Consumer Health Sa Composicion topica que comprende terbinafina e hidrocortisona
US20050238672A1 (en) 2004-04-27 2005-10-27 Nimni Marcel E Antifungal drug delivery
AU2005258903A1 (en) * 2004-07-02 2006-01-12 Warner-Lambert Company Llc Compositions and methods for treating pathological infections
FR2892023B1 (fr) 2005-10-14 2009-09-25 Galderma Sa Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale
EP1958639A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans for the treatment of nail inflammatory diseases
EP1958638A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans to increase nail growth rate
EP1958613A1 (en) * 2007-02-15 2008-08-20 Polichem S.A. Dermal film-forming liquid formulations for drug release to skin
WO2008121709A1 (en) 2007-03-30 2008-10-09 Transport Pharmaceuticals, Inc. Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug
AU2009275230A1 (en) 2008-07-23 2010-01-28 Targeted Delivery Technologies Limited Methods of administering topical antifungal formulations for the treatment of fungal infections
US7903569B2 (en) 2008-11-25 2011-03-08 At&T Intellectual Property I, L.P. Diagnosing network problems in an IPV6 dual stack network
WO2010138674A1 (en) 2009-05-29 2010-12-02 Stiefel Laboratories, Inc. Azole antifungal compositions
JP5339152B2 (ja) 2009-12-18 2013-11-13 横河電機株式会社 電空変換器
FR2954163B1 (fr) 2009-12-18 2012-03-16 Galderma Pharma Sa Utilisation d'un tensioactif cationique, avantageu-sement amphotere, pour la preparation d'une composition antifongique applicable sur l'ongle
EP2544659A2 (en) * 2009-12-23 2013-01-16 Nuvo Research Inc. Highly permeating terbinafine formulation for treating onychomycosis
EP2345643A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
RU2432158C1 (ru) 2010-07-28 2011-10-27 Закрытое акционерное общество "Институт прикладной нанотехнологии" Профилактический бактерицидный лак для обработки ногтей
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis

Also Published As

Publication number Publication date
DK2953621T3 (da) 2019-06-17
LT2953621T (lt) 2019-06-10
ME03507B (me) 2020-04-20
HRP20191243T1 (hr) 2019-11-01
US20150366822A1 (en) 2015-12-24
MX2015010203A (es) 2016-04-28
NZ709668A (en) 2020-06-26
CA2900127A1 (en) 2014-08-14
TW201440810A (zh) 2014-11-01
CL2015002191A1 (es) 2016-05-20
PT2953621T (pt) 2019-06-07
CR20150377A (es) 2015-09-24
PH12015501739A1 (en) 2015-10-19
ES2729373T3 (es) 2019-11-04
PL2953621T3 (pl) 2019-09-30
PE20151300A1 (es) 2015-09-16
US10172811B2 (en) 2019-01-08
BR112015018798B1 (pt) 2022-03-29
EP2953621B1 (en) 2019-05-01
KR20150112969A (ko) 2015-10-07
CN105050592A (zh) 2015-11-11
WO2014122024A1 (en) 2014-08-14
HK1212904A1 (zh) 2016-06-24
TWI658839B (zh) 2019-05-11
TN2015000316A1 (en) 2017-01-03
CA2900127C (en) 2021-02-09
US9107877B2 (en) 2015-08-18
AU2014214166A1 (en) 2015-08-13
KR102200788B1 (ko) 2021-01-13
US20140296347A1 (en) 2014-10-02
UY35307A (es) 2014-06-30
ECSP15033898A (es) 2015-11-30
US8697753B1 (en) 2014-04-15
PH12015501739B1 (en) 2015-10-19
JP2016507540A (ja) 2016-03-10
EA036061B1 (ru) 2020-09-22
MX361880B (es) 2018-12-18
CN105050592B (zh) 2018-04-24
HUE045000T2 (hu) 2019-11-28
BR112015018798A2 (pt) 2017-07-18
EA201500830A1 (ru) 2016-05-31
SG11201505275YA (en) 2015-08-28
ZA201504880B (en) 2016-12-21
EP2953621A1 (en) 2015-12-16
JP6420258B2 (ja) 2018-11-07
AU2014214166A2 (en) 2015-09-03
RS58990B1 (sr) 2019-08-30
IL240334B (en) 2019-11-28
SI2953621T1 (sl) 2019-07-31
AU2014214166B2 (en) 2018-07-26
IL240334A0 (en) 2015-09-24

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