CL2015002191A1 - Composición antifúngica tópica para el tratamiento de onicomicosis. - Google Patents

Composición antifúngica tópica para el tratamiento de onicomicosis.

Info

Publication number
CL2015002191A1
CL2015002191A1 CL2015002191A CL2015002191A CL2015002191A1 CL 2015002191 A1 CL2015002191 A1 CL 2015002191A1 CL 2015002191 A CL2015002191 A CL 2015002191A CL 2015002191 A CL2015002191 A CL 2015002191A CL 2015002191 A1 CL2015002191 A1 CL 2015002191A1
Authority
CL
Chile
Prior art keywords
treatment
onychomycosis
antifungal composition
topical antifungal
topical
Prior art date
Application number
CL2015002191A
Other languages
English (en)
Inventor
Federico Mailland
Michela Legora
Daniela Ceriani
Guiliana Iob
Original Assignee
Polichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50029007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002191(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of CL2015002191A1 publication Critical patent/CL2015002191A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSICION FARMACEUTICA ANTIFUNGICA, EN FORMA DE UN ESMALTE DE UÑAS, QUE CONSISTE EN TERBINAFINA, HIDROXIPROPIL QUITOSANO, AGUA Y UN ALCANOL; SU USO PARA EL TRATAMIENTO DE ONICOMICOSIS.
CL2015002191A 2013-02-07 2015-08-05 Composición antifúngica tópica para el tratamiento de onicomicosis. CL2015002191A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361761953P 2013-02-07 2013-02-07
US201361781560P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
CL2015002191A1 true CL2015002191A1 (es) 2016-05-20

Family

ID=50029007

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002191A CL2015002191A1 (es) 2013-02-07 2015-08-05 Composición antifúngica tópica para el tratamiento de onicomicosis.

Country Status (35)

Country Link
US (3) US8697753B1 (es)
EP (1) EP2953621B1 (es)
JP (1) JP6420258B2 (es)
KR (1) KR102200788B1 (es)
CN (1) CN105050592B (es)
AU (1) AU2014214166B2 (es)
BR (1) BR112015018798B1 (es)
CA (1) CA2900127C (es)
CL (1) CL2015002191A1 (es)
CR (1) CR20150377A (es)
CY (1) CY1121841T1 (es)
DK (1) DK2953621T3 (es)
EA (1) EA036061B1 (es)
EC (1) ECSP15033898A (es)
ES (1) ES2729373T3 (es)
HK (1) HK1212904A1 (es)
HR (1) HRP20191243T1 (es)
HU (1) HUE045000T2 (es)
IL (1) IL240334B (es)
LT (1) LT2953621T (es)
ME (1) ME03507B (es)
MX (1) MX361880B (es)
NZ (1) NZ709668A (es)
PE (1) PE20151300A1 (es)
PH (1) PH12015501739B1 (es)
PL (1) PL2953621T3 (es)
PT (1) PT2953621T (es)
RS (1) RS58990B1 (es)
SG (1) SG11201505275YA (es)
SI (1) SI2953621T1 (es)
TN (1) TN2015000316A1 (es)
TW (1) TWI658839B (es)
UY (1) UY35307A (es)
WO (1) WO2014122024A1 (es)
ZA (1) ZA201504880B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
KR101580077B1 (ko) * 2015-03-28 2015-12-24 한국콜마주식회사 시크로피록스 함유 네일락카 조성물
GB201605127D0 (en) * 2016-03-25 2016-05-11 Blueberry Therapeutics Ltd Composition and methods of treatment
DE102019003486B4 (de) * 2019-05-17 2021-03-18 L/N Health And Beauty Aps Zusammensetzungen zur Behandlung der Onychomykose
EP4076391A1 (en) * 2019-12-20 2022-10-26 GlaxoSmithKline Consumer Healthcare Holdings (US) LLC Topical pharmaceutical compositions for treating onychomycosis

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883545A (en) 1968-08-31 1975-05-13 Hoechst Ag Certain 1-hydroxy-2-pyridones
AT354187B (de) 1976-11-22 1979-12-27 Hoffmann La Roche Fungizides mittel
DE19375084I2 (de) 1979-08-22 2000-11-16 Novartis Ag Propenylamine Verfahren zu ihrer Herstellung sie enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung als Arzneimittel
DE3045915A1 (de) 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3045914A1 (de) 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3245784A1 (de) 1982-12-10 1984-06-14 Wella Ag, 6100 Darmstadt Kosmetisches mittel auf der basis von quaternaeren chitosanderivaten, neue quaternaere chitosanderivate sowie verfahren zu ihrer herstellung
DE3502833A1 (de) 1985-01-29 1986-07-31 Wella Ag, 6100 Darmstadt Kosmetische mittel auf der basis von quaternaeren chitosanderivaten, neue quaternaere hydroxyethyl-substituierte chitosanderivate sowie verfahren zu ihrer herstellung
DE3513277A1 (de) 1985-04-13 1986-10-23 Wella Ag, 6100 Darmstadt Kosmetische mittel auf der basis von quaternaeren hydroxyalkyl-substituierten chitosanderivaten
EP0247142B1 (en) 1985-11-04 1993-01-07 Owen/Galderma Laboratories Inc. Film-forming, pharmaceutical vehicles for application of medicaments to nails, pharmaceutical compositions based on those vehicles, and methods of using same
DE3541305A1 (de) 1985-11-22 1987-05-27 Wella Ag Kosmetische mittel auf der basis von n-hydroxypropylchitosanen, neue n-hydroxypropyl-chitosane sowie verfahren zu ihrer herstellung
DE3544983A1 (de) 1985-12-19 1987-06-25 Hoechst Ag Antimykotisch wirksamer nagellack
DE3545929A1 (de) 1985-12-23 1987-06-25 Ceag Licht & Strom Gehaeuse
SE460713B (sv) 1986-04-22 1989-11-13 Atlas Copco Ab Hydrauliskt momentimpulsverk
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
DE3703760A1 (de) 1987-02-07 1988-08-18 Wella Ag Kosmetisches mittel auf der basis von n-hydroxypropylisopropyletherchitosanen, sowie neue n-hydroxypropylisopropyletherderivate des chitosans
HU200914B (en) 1987-03-09 1990-09-28 Horvath Gyoengyi Lengyelne Process for producing new medical dosage unit suitable for local treatment of fungus infection of nails
DE3720147A1 (de) 1987-06-16 1988-12-29 Hoechst Ag Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
DE3723811A1 (de) 1987-07-18 1989-01-26 Wella Ag Nagellack auf der basis von o-benzyl-n-hydroxyalkylchitosanen sowie neue o-benzyl-n-hydroxyalkylderivate des chitosans
CA2008775C (en) 1989-02-24 1998-12-22 Alberto Ferro Nail lacquer
FR2673537B1 (fr) 1991-03-08 1993-06-11 Oreal Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.
DE4108664C2 (de) 1991-03-16 1995-03-09 Scheller Cosmetics Gmbh Dr Nagellack und Verwendung desselben
US6005001A (en) 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU223343B1 (hu) 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
DE4212105A1 (de) 1992-04-10 1993-10-14 Roehm Pharma Gmbh Nagellack zur Behandlung von Onychomykosen
JPH05339152A (ja) 1992-06-09 1993-12-21 Nippon Soda Co Ltd 皮膚病変局所投与薬剤含有キトサン誘導体フィルム剤
JPH06211651A (ja) 1993-01-12 1994-08-02 Hisamitsu Pharmaceut Co Inc 爪白癬治療用組成物
DE19518262A1 (de) 1995-05-18 1996-11-21 Hoechst Ag Die Verwendung von Glyceryltriacetat zur Behandlung von Onychomykosen
US5391367A (en) 1993-07-28 1995-02-21 Pfizer Inc. Antifungal nail solution
US5487776A (en) 1994-03-17 1996-01-30 Nimni; Marcel Anti-fungal nail lacquer and method therefor
JP2951725B2 (ja) 1994-10-13 1999-09-20 久光製薬株式会社 爪白癬用外用組成物
AU3673195A (en) 1994-10-13 1996-05-06 Hisamitsu Pharmaceutical Co., Inc. External preparation for nail ringworm
US5696164A (en) 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
DE19503423A1 (de) 1995-02-03 1996-08-08 Beiersdorf Ag Antiadhäsive Wirkstoffe
ATE265851T1 (de) 1995-03-03 2004-05-15 Solomon B Margolin Behandlung von erkrankungen, die vom cytokinwachstumsfaktor verursacht werden
DE19604190A1 (de) 1996-02-06 1997-08-07 Hoechst Ag Nagelwachstumsfördernde Zubereitungen
BR9706543A (pt) 1996-08-01 1999-12-28 Dale Wallis Serpens spp biologicamente pura cepa hbl-112, composição farmacêutica e processos para evitar e/ou tratar dermatite digital papilomatosa de ruminante, e para determinar a presença de anticorpos pdd em uma amostra de soro e de anticorpos anti-serpens spp. em um ruminante, e, kit de diagnóstico
JP4253047B2 (ja) 1996-09-27 2009-04-08 杏林製薬株式会社 被膜形成性抗真菌剤組成物
JP4227677B2 (ja) 1996-12-10 2009-02-18 杏林製薬株式会社 被膜形成性抗真菌剤組成物
FR2761886B1 (fr) 1997-04-14 2000-05-05 Virbac Sa Compositions contenant au moins un polymere cationique et au moins une molecule active contenue dans au moins un vecteur micro ou nanoparticulaire, et leur utilisation pour le traitement de surfaces vivantes ou inertes
US5991438A (en) 1997-07-31 1999-11-23 Hewlett-Packard Company Color halftone error-diffusion with local brightness variation reduction
DK0983037T3 (da) 1998-02-09 2003-09-01 Macrochem Corp Fungicid neglelak
EP1069898B1 (en) 1998-03-17 2004-05-12 MARGOLIN, Solomon B. Topical antiseptic compositions and methods
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
IL138889A0 (en) 1998-04-17 2001-11-25 Bertek Pharm Inc Topical formulations for the treatment of nail fungal diseases
US6306375B1 (en) 1998-05-01 2001-10-23 The Procter & Gamble Company Long wear nail polish having defined surface properties
US5965111A (en) 1998-05-01 1999-10-12 The Procter & Gamble Company Fast drying water-borne nail polish
US6284234B1 (en) 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
JP5170486B2 (ja) 1998-09-10 2013-03-27 バイオイコール ア−ゲー 局所適用性産物
DE19841796A1 (de) 1998-09-12 2000-03-16 Beiersdorf Ag Kombinationen von Antiadhäsiva (Kohlenhydrate) und Mikrobiziden
US6159977A (en) 1998-11-16 2000-12-12 Astan, Inc. Therapeutic anti-fungal nail preparation
ATE249811T1 (de) 1999-02-09 2003-10-15 Cognis Deutschland Gmbh Verwendung von nanoskaligen chitosanen
ES2199094T1 (es) 1999-08-19 2004-02-16 Lavipharm Sa Polimeros formadores de pelicula, procedimientos de uso y aplicaciones de los mismos.
DE19960632A1 (de) 1999-12-16 2001-07-05 Cognis Deutschland Gmbh Kosmetische Mittel enthaltend natürliche Chitosane
US20030012749A1 (en) 2000-01-03 2003-01-16 Karl Kraemer Preparations for the non-traumatic excision of a nail
NZ520749A (en) 2000-02-16 2004-06-25 Bentley Pharmaceuticals Inc Pharmaceutical composition comprising a drug, a membrane-compatible permeation enhancer and a polymeric film-forming agent
DE10011081A1 (de) 2000-03-09 2001-09-13 Aventis Pharma Gmbh Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel
US7074392B1 (en) 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
DE10035991A1 (de) 2000-07-24 2002-02-14 Polichem Sa Nagellackzusammensetzung
GB0019283D0 (en) 2000-08-04 2000-09-27 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
US6676953B2 (en) 2001-01-26 2004-01-13 Don L. Hexamer Antifungal composition and method for human nails
US20030118655A1 (en) 2001-12-21 2003-06-26 Nikhil Kundel Film forming liquid composition
US6921529B2 (en) 2002-07-29 2005-07-26 Joseph C. Maley Treatment modality and method for fungal nail infection
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
NZ542904A (en) 2003-03-21 2009-04-30 Nexmed Holdings Inc Antifungal nail coat and method of use
EP1491202A1 (en) 2003-06-23 2004-12-29 Polichem S.A. Nail restructuring compositions for topical application
CA2533720A1 (fr) 2003-07-29 2005-02-10 Pierre Fabre Dermo-Cosmetique Vernis a ongles a action antimycosique
AR045241A1 (es) 2003-08-12 2005-10-19 Novartis Consumer Health Sa Composicion topica que comprende terbinafina e hidrocortisona
US20050238672A1 (en) 2004-04-27 2005-10-27 Nimni Marcel E Antifungal drug delivery
EP1763341A2 (en) 2004-07-02 2007-03-21 Warner-Lambert Company LLC Compositions and methods for treating pathological infections
FR2892023B1 (fr) 2005-10-14 2009-09-25 Galderma Sa Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale
EP1958639A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans for the treatment of nail inflammatory diseases
EP1958638A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans to increase nail growth rate
EP1958613A1 (en) * 2007-02-15 2008-08-20 Polichem S.A. Dermal film-forming liquid formulations for drug release to skin
US20080261986A1 (en) 2007-03-30 2008-10-23 Friden Phillip M Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug
CN102159202A (zh) * 2008-07-23 2011-08-17 靶向递送技术有限公司 施用局部抗真菌制剂治疗真菌感染的方法
US7903569B2 (en) 2008-11-25 2011-03-08 At&T Intellectual Property I, L.P. Diagnosing network problems in an IPV6 dual stack network
ES2548998T3 (es) 2009-05-29 2015-10-22 Palau Pharma, S.A. Composiciones antifúngicas de azol
JP5339152B2 (ja) 2009-12-18 2013-11-13 横河電機株式会社 電空変換器
FR2954163B1 (fr) 2009-12-18 2012-03-16 Galderma Pharma Sa Utilisation d'un tensioactif cationique, avantageu-sement amphotere, pour la preparation d'une composition antifongique applicable sur l'ongle
CN102770123A (zh) * 2009-12-23 2012-11-07 纽沃研究股份有限公司 用于治疗甲癣的高渗透性特比萘芬制剂
EP2345643A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
RU2432158C1 (ru) 2010-07-28 2011-10-27 Закрытое акционерное общество "Институт прикладной нанотехнологии" Профилактический бактерицидный лак для обработки ногтей
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis

Also Published As

Publication number Publication date
IL240334B (en) 2019-11-28
CA2900127A1 (en) 2014-08-14
SI2953621T1 (sl) 2019-07-31
EA036061B1 (ru) 2020-09-22
SG11201505275YA (en) 2015-08-28
EP2953621A1 (en) 2015-12-16
NZ709668A (en) 2020-06-26
CN105050592A (zh) 2015-11-11
US9107877B2 (en) 2015-08-18
US20140296347A1 (en) 2014-10-02
PH12015501739A1 (en) 2015-10-19
BR112015018798B1 (pt) 2022-03-29
AU2014214166A1 (en) 2015-08-13
LT2953621T (lt) 2019-06-10
TWI658839B (zh) 2019-05-11
IL240334A0 (en) 2015-09-24
KR20150112969A (ko) 2015-10-07
EA201500830A1 (ru) 2016-05-31
PL2953621T3 (pl) 2019-09-30
WO2014122024A1 (en) 2014-08-14
AU2014214166A2 (en) 2015-09-03
MX2015010203A (es) 2016-04-28
CN105050592B (zh) 2018-04-24
ECSP15033898A (es) 2015-11-30
ZA201504880B (en) 2016-12-21
CA2900127C (en) 2021-02-09
RS58990B1 (sr) 2019-08-30
KR102200788B1 (ko) 2021-01-13
CY1121841T1 (el) 2020-07-31
EP2953621B1 (en) 2019-05-01
TN2015000316A1 (en) 2017-01-03
US10172811B2 (en) 2019-01-08
PH12015501739B1 (en) 2015-10-19
TW201440810A (zh) 2014-11-01
AU2014214166B2 (en) 2018-07-26
US8697753B1 (en) 2014-04-15
BR112015018798A2 (pt) 2017-07-18
HRP20191243T1 (hr) 2019-11-01
PT2953621T (pt) 2019-06-07
ES2729373T3 (es) 2019-11-04
CR20150377A (es) 2015-09-24
HUE045000T2 (hu) 2019-11-28
HK1212904A1 (zh) 2016-06-24
US20150366822A1 (en) 2015-12-24
DK2953621T3 (da) 2019-06-17
JP2016507540A (ja) 2016-03-10
ME03507B (me) 2020-04-20
MX361880B (es) 2018-12-18
PE20151300A1 (es) 2015-09-16
UY35307A (es) 2014-06-30
JP6420258B2 (ja) 2018-11-07

Similar Documents

Publication Publication Date Title
CO2017001994A2 (es) Compuestos activos hacia bromodominios
CL2016002735A1 (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
BR112016000489A2 (pt) composto, composição farmacêutica que o compreende, uso da composição e métodos para fabricar compostos
DOP2015000274A (es) Compuestos químicos
BR112016020199A2 (pt) Composto inibidor de calicreína plasmática de humano, composição farmacêutica compreendendo o referido composto, kit e seu uso
CL2014002873A1 (es) Compuestos derivados de pirimidin-amina o triazin-amina, inhibidores de adn-pk; composicion farmaceutica; y su uso para el tratamiento del cancer.
CL2014002348A1 (es) Compuestos derivados de fenicol; composicion farmaceutica que los comprende; y su uso para controlar o tratar infecciones bacterianas en ganado.
BR112015011756A2 (pt) inibidores da glutamase e métodos de uso
CO6811867A2 (es) Cannabinoides para uso en el tratamiento del dolor neuropático
CL2015002191A1 (es) Composición antifúngica tópica para el tratamiento de onicomicosis.
CL2014003339A1 (es) Anticuerpo humanizado anti-trka con propiedades inhibitorias mejoradas; composición que lo comprende; y uso para tratar el dolor.
AR125920A2 (es) Composiciones que comprenden vortioxetina y donepezil
BR112016017112A2 (pt) Composições de apilimod e métodos de uso das mesmas
CL2013001324A1 (es) Kit que comprende ec145 y uno o mas agentes quimioterapéuticos adicionales; uso para tratar un cancer.
CL2015002180A1 (es) Terapia de combinación para el tratamiento de neumonía nosocomial
BR112016027043A2 (pt) Combinação, composição farmacêutica compreendendo glucocorticoide e edo-s101, kit e uso no tratamento de câncer
CL2019003670A1 (es) Composición que comprende manosa oligosacárido y proceso para realizarla y uso de esta.
CL2017000394A1 (es) Composición que contiene cineol para la administración nasal
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
DOP2015000298A (es) Compuestos nuevos para el tratamiento del cáncer
ES2970485T3 (es) Composición farmacéutica para su uso en el tratamiento de enfermedades cardiovasculares
PE20150167A1 (es) (r)-nifuratel, su uso para el tratamiento de las infecciones y sintesis de (r) y (s)-nifuratel
BR112016026774A2 (pt) uso de inibidores de proteassoma contendo boro após terapia de câncer primária e composição farmacêutica.
CL2015001502A1 (es) Composición farmacéutica que comprende desloratadina y prendnisolona y uso de la misma.
BR112017011685A2 (pt) composições compreendendo 15-hepe e métodos de tratamento ou prevenção da fibrose usando as mesmas