HRP20191243T1 - Topikalni antifugalni pripravak za liječenje onihomikoze - Google Patents
Topikalni antifugalni pripravak za liječenje onihomikoze Download PDFInfo
- Publication number
- HRP20191243T1 HRP20191243T1 HRP20191243T HRP20191243T1 HR P20191243 T1 HRP20191243 T1 HR P20191243T1 HR P20191243 T HRP20191243 T HR P20191243T HR P20191243 T1 HRP20191243 T1 HR P20191243T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- mass
- amount
- treatment
- terbinafine
- Prior art date
Links
- 208000010195 Onychomycosis Diseases 0.000 title claims 3
- 201000005882 tinea unguium Diseases 0.000 title claims 3
- 239000012871 anti-fungal composition Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 7
- 229960002722 terbinafine Drugs 0.000 claims 7
- 239000004615 ingredient Substances 0.000 claims 5
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- 239000008213 purified water Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (19)
1. Pripravak koji sadrži najmanje oko 9 % masenog udjela terbinafina ili njegove farmaceutski prihvatljive soli, hidroksipropil hitozan, niži alkanol i vodu za primjenu u liječenju onihomikoze kod pacijenta, naznačen time, što se spomenuti pripravak nanosi na pogođena područja pacijenta jednom tjedno.
2. Pripravak za primjenu prema patentnom zahtjevu 1, naznačen time, što razdoblje liječenja inicijalnom dozom prethodni tjednom nanošenju.
3. Pripravak za primjenu prema patentnom zahtjevu 2, naznačen time, što se razdoblje liječenja inicijalnom dozom sastoji od dnevnog nanošenja tijekom vremenskog razdoblja od dva tjedna do dva mjeseca.
4. Pripravak za primjenu prema patentnom zahtjevu 3, naznačen time, što se razdoblje liječenja inicijalnom dozom sastoji od dnevnog nanošenja tijekom mjesec dana.
5. Pripravak za primjenu prema patentnom zahtjevu 1, naznačen time, što je terbinafin ili njegova farmaceutski prihvatljiva sol prisutna u količini od 9,5 % do 10,5 % masenog udjela.
6. Pripravak za primjenu prema patentnom zahtjevu 1, naznačen time, što je spomenuti niži alkanol etanol.
7. Pripravak za primjenu prema patentnom zahtjevu 1, naznačen time, što je spomenuta farmaceutski prihvatljiva sol terbinafin HCl.
8. Pripravak koji se suštinski sastoji od:
a) terbinafina i/ili najmanje njegove farmaceutski prihvatljive soli u količini od 9 do 11 % masenog udjela pripravka,
b) hidroksipropil hitozan u količini od 0,1 do 0,6 % masenog udjela pripravka,
c) vode u količini od 10,0 do 40,0 % masenog udjela pripravka,
d) najmanje nižeg alkanola u količini od 60 do 80 % masenog udjela pripravka.
9. Pripravak prema patentnom zahtjevu 8, naznačen time, što je sastojak a) terbinafin HCl.
10. Pripravak prema patentnom zahtjevu 8, naznačen time, što je sastojak b) prisutan u količini od 0,2 do 0,4 % masenog udjela pripravka.
11. Pripravak prema patentnom zahtjevu 8, naznačen time, što je sastojak c) prisutan u količini od 18 do 30 % masenog udjela pripravka.
12. Pripravak prema patentnom zahtjevu 8, naznačen time, što je sastojak d) odabran iz etanola, propanola, izopropanola, butanola i njihovih smjesa.
13. Pripravak prema patentnom zahtjevu 12, naznačen time, što je sastojak d) etanol.
14. Pripravak prema patentnom zahtjevu 8, koji se sastoji od a) 9,5 do 10,5 % masenog udjela terbinafin HCl-a, b) 0,2 do 0,4 % masenog udjela hidroksipropil hitozana, c) 18 do 30 % masenog udjela pročišćene vode i d) 65 do 75 % masenog udjela etanola.
15. Pripravak prema patentnom zahtjevu 14, koji se sastoji od a) oko 10 % masenog udjela terbinafin HCl-a, b) oko 0,3 % masenog udjela hidroksipropil hitozana, c) oko 19,7 % masenog udjela pročišćene vode i d) oko 70 % masenog udjela etanola.
16. Pripravak prema patentnom zahtjevu 8, naznačen time, što je u obliku laka za nokte.
17. Pripravak prema bilo kojem patentnom zahtjevu od 8 do 16 za primjenu u liječenju onihomikoze.
18. Pripravak za primjenu prema patentnom zahtjevu 17, naznačen time, što se pripravak nanosi jednom tjedno.
19. Pripravak za primjenu prema patentnom zahtjevu 17, naznačen time, što se pripravak nanosi jednom dnevno tijekom prvih mjesec dana, a zatim jednom tjedno do kraja liječenja.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761953P | 2013-02-07 | 2013-02-07 | |
| US201361781560P | 2013-03-14 | 2013-03-14 | |
| PCT/EP2014/051288 WO2014122024A1 (en) | 2013-02-07 | 2014-01-23 | Topical antifungal composition for treating onychomycosis |
| EP14701713.1A EP2953621B1 (en) | 2013-02-07 | 2014-01-23 | Topical antifungal composition for treating onychomycosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191243T1 true HRP20191243T1 (hr) | 2019-11-01 |
Family
ID=50029007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191243 HRP20191243T1 (hr) | 2013-02-07 | 2019-07-11 | Topikalni antifugalni pripravak za liječenje onihomikoze |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US8697753B1 (hr) |
| EP (1) | EP2953621B1 (hr) |
| JP (1) | JP6420258B2 (hr) |
| KR (1) | KR102200788B1 (hr) |
| CN (1) | CN105050592B (hr) |
| AU (1) | AU2014214166B2 (hr) |
| BR (1) | BR112015018798B1 (hr) |
| CA (1) | CA2900127C (hr) |
| CL (1) | CL2015002191A1 (hr) |
| CR (1) | CR20150377A (hr) |
| CY (1) | CY1121841T1 (hr) |
| DK (1) | DK2953621T3 (hr) |
| EA (1) | EA036061B1 (hr) |
| EC (1) | ECSP15033898A (hr) |
| ES (1) | ES2729373T3 (hr) |
| HK (1) | HK1212904A1 (hr) |
| HR (1) | HRP20191243T1 (hr) |
| HU (1) | HUE045000T2 (hr) |
| IL (1) | IL240334B (hr) |
| LT (1) | LT2953621T (hr) |
| ME (1) | ME03507B (hr) |
| MX (1) | MX361880B (hr) |
| NZ (1) | NZ709668A (hr) |
| PE (1) | PE20151300A1 (hr) |
| PH (1) | PH12015501739B1 (hr) |
| PL (1) | PL2953621T3 (hr) |
| PT (1) | PT2953621T (hr) |
| RS (1) | RS58990B1 (hr) |
| SG (1) | SG11201505275YA (hr) |
| SI (1) | SI2953621T1 (hr) |
| TN (1) | TN2015000316A1 (hr) |
| TW (1) | TWI658839B (hr) |
| UY (1) | UY35307A (hr) |
| WO (1) | WO2014122024A1 (hr) |
| ZA (1) | ZA201504880B (hr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697753B1 (en) * | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| KR101580077B1 (ko) * | 2015-03-28 | 2015-12-24 | 한국콜마주식회사 | 시크로피록스 함유 네일락카 조성물 |
| GB201605127D0 (en) * | 2016-03-25 | 2016-05-11 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| DE102019003486B4 (de) * | 2019-05-17 | 2021-03-18 | L/N Health And Beauty Aps | Zusammensetzungen zur Behandlung der Onychomykose |
| WO2021127107A1 (en) * | 2019-12-20 | 2021-06-24 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Topical pharmaceutical compositions for treating onychomycosis |
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