CY1118084T1 - ΠΑΡΑΓΩΓΑ ΤΟΥ 7-(ΕΤΕΡΟΑΡΥΛ-ΑΜΙΝΟ)-6,7,8,9-ΤΕΤΡΑΫΔΡΟΠΥΡΙΔΟ[1,2-α]ΙΝΔΟΛΟ ΟΞΙΚΟΥ ΟΞΕΟΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΤΡΟΠΟΠΟΙΗΤΕΣ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΣΤΑΓΛΑΝΔΙΝΗΣ D2 - Google Patents
ΠΑΡΑΓΩΓΑ ΤΟΥ 7-(ΕΤΕΡΟΑΡΥΛ-ΑΜΙΝΟ)-6,7,8,9-ΤΕΤΡΑΫΔΡΟΠΥΡΙΔΟ[1,2-α]ΙΝΔΟΛΟ ΟΞΙΚΟΥ ΟΞΕΟΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΤΡΟΠΟΠΟΙΗΤΕΣ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΣΤΑΓΛΑΝΔΙΝΗΣ D2Info
- Publication number
- CY1118084T1 CY1118084T1 CY20161101009T CY161101009T CY1118084T1 CY 1118084 T1 CY1118084 T1 CY 1118084T1 CY 20161101009 T CY20161101009 T CY 20161101009T CY 161101009 T CY161101009 T CY 161101009T CY 1118084 T1 CY1118084 T1 CY 1118084T1
- Authority
- CY
- Cyprus
- Prior art keywords
- heteroaryl
- derivatives
- amino
- acetic acid
- tetrahydrofluoride
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με παράγωγα του 7-(ετεροαρυλ-αμινο)-6,7,8,9-τετραϋδροπυριδο[1,2-a]ινδολο οξικού οξέος με τον τύπο (I), όπου τα R1, R2, R3 και R4 είναι όπως περιγράφονται στην περιγραφή και με τη χρήση τους ως τροποποιητές του υποδοχέα της προσταγλανδίνης, ειδικότερα ως τροποποιητές του υποδοχέα της προσταγλανδίνης D2, στη θεραπευτική αντιμετώπιση ποικίλων νόσων και διαταραχών στις οποίες διαμεσολαβεί η προσταγλανδίνη, με φαρμακευτικές συνθέσεις οι οποίες περιέχουν τις ενώσεις αυτές και με διαδικασίες για την παρασκευή τους.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2011051615 | 2011-04-14 | ||
PCT/IB2012/051831 WO2012140612A1 (en) | 2011-04-14 | 2012-04-13 | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118084T1 true CY1118084T1 (el) | 2017-06-28 |
Family
ID=46125478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161101009T CY1118084T1 (el) | 2011-04-14 | 2016-10-11 | ΠΑΡΑΓΩΓΑ ΤΟΥ 7-(ΕΤΕΡΟΑΡΥΛ-ΑΜΙΝΟ)-6,7,8,9-ΤΕΤΡΑΫΔΡΟΠΥΡΙΔΟ[1,2-α]ΙΝΔΟΛΟ ΟΞΙΚΟΥ ΟΞΕΟΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΤΡΟΠΟΠΟΙΗΤΕΣ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΣΤΑΓΛΑΝΔΙΝΗΣ D2 |
Country Status (27)
Country | Link |
---|---|
US (1) | US9096595B2 (el) |
EP (1) | EP2697223B1 (el) |
JP (1) | JP5964945B2 (el) |
KR (1) | KR101928595B1 (el) |
CN (1) | CN103459389B (el) |
AU (1) | AU2012241442B2 (el) |
BR (1) | BR112013026283A8 (el) |
CA (1) | CA2830204C (el) |
CL (1) | CL2013002832A1 (el) |
CY (1) | CY1118084T1 (el) |
DK (1) | DK2697223T3 (el) |
ES (1) | ES2596581T3 (el) |
HR (1) | HRP20161235T1 (el) |
HU (1) | HUE028972T2 (el) |
IL (1) | IL228820A (el) |
LT (1) | LT2697223T (el) |
MA (1) | MA35102B1 (el) |
MX (1) | MX338516B (el) |
MY (1) | MY165623A (el) |
PL (1) | PL2697223T3 (el) |
PT (1) | PT2697223T (el) |
RU (1) | RU2596823C2 (el) |
SG (1) | SG193902A1 (el) |
SI (1) | SI2697223T1 (el) |
UA (1) | UA110245C2 (el) |
WO (1) | WO2012140612A1 (el) |
ZA (1) | ZA201308497B (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012024114B1 (pt) | 2010-03-22 | 2021-02-09 | Idorsia Pharmaceuticals Ltd | Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica |
LT3119779T (lt) | 2014-03-17 | 2018-09-10 | Idorsia Pharmaceuticals Ltd | Azaindolo acto rūgšties dariniai ir jų panaudojimas kaip prostaglandino d2 receptoriaus moduliatorių |
TW201620909A (zh) | 2014-03-18 | 2016-06-16 | 艾克泰聯製藥有限公司 | 氮雜吲哚乙酸衍生物及彼等作為前列腺素d2受體調節劑之用途 |
MX2018003202A (es) | 2015-09-15 | 2018-06-08 | Idorsia Pharmaceuticals Ltd | Formas cristalinas. |
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-
2012
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- 2012-04-13 MY MYPI2013701918A patent/MY165623A/en unknown
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- 2012-04-13 MX MX2013011937A patent/MX338516B/es active IP Right Grant
- 2012-04-13 BR BR112013026283A patent/BR112013026283A8/pt not_active Application Discontinuation
- 2012-04-13 SI SI201230706A patent/SI2697223T1/sl unknown
- 2012-04-13 ES ES12722194.3T patent/ES2596581T3/es active Active
- 2012-04-13 PL PL12722194T patent/PL2697223T3/pl unknown
- 2012-04-13 DK DK12722194.3T patent/DK2697223T3/en active
- 2012-04-13 LT LTEP12722194.3T patent/LT2697223T/lt unknown
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- 2012-04-13 CN CN201280017738.8A patent/CN103459389B/zh not_active Expired - Fee Related
- 2012-04-13 RU RU2013150527/04A patent/RU2596823C2/ru not_active IP Right Cessation
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- 2012-04-13 EP EP12722194.3A patent/EP2697223B1/en active Active
- 2012-04-13 WO PCT/IB2012/051831 patent/WO2012140612A1/en active Application Filing
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- 2013-11-07 MA MA36397A patent/MA35102B1/fr unknown
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