CY1117852T1 - Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα - Google Patents

Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα

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Publication number
CY1117852T1
CY1117852T1 CY20161100724T CY161100724T CY1117852T1 CY 1117852 T1 CY1117852 T1 CY 1117852T1 CY 20161100724 T CY20161100724 T CY 20161100724T CY 161100724 T CY161100724 T CY 161100724T CY 1117852 T1 CY1117852 T1 CY 1117852T1
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Cyprus
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exon
cell
skipping
production
instance
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CY20161100724T
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English (en)
Inventor
Ommen Garrit-Jan Boudewijn Van
Deutekom Judith Christina Theodora Van
Dunnen Johannes Theodorus Den
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Academisch Ziekenhuis Leiden
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8172043&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117852(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Publication of CY1117852T1 publication Critical patent/CY1117852T1/el

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Abstract

Η παρούσα εφεύρεση παρέχει μία μέθοδο για μείωση τουλάχιστον εν μέρει της παραγωγής μιας παρεκκλίνουσας πρωτεΐνης σε ένα κύτταρο και το εν λόγω κύτταρο περιέχει pre-mRNA το οποίον περιλαμβάνει εξώνια που κωδικεύουν αυτή την πρωτεΐνη, με επαγωγή της λεγομένης παράκαμψης εξωνίου στο εν λόγω κύτταρο. Η παράκαμψη εξωνίου έχει σαν αποτέλεσμα ώριμο mRNA που δεν περιέχει το παρακαμφθέν εξώνιο το οποίον οδηγεί σε ένα αλλαγμένο προϊόν εάν το εν λόγω εξώνιο κωδικεύει αμινοξέα. Η παράκαμψη εξωνίου διεξάγεται με εφοδιασμό ενός κυττάρου με έναν παράγοντα ικανό για ειδική αναστολή σήματος συμπερίληψης εξωνίου, για παράδειγμα μία αλληλουχία αναγνώρισης εξωνίου του εν λόγω εξωνίου. Το εν λόγω σήμα έγκλεισης εξωνίου μπορεί να παρέμβει σε ένα νουκλεϊνικό οξύ που περιλαμβάνει συμπληρωματικότητα για ένα μέρος αυτού του εξωνίου. Το εν λόγω νουκλεϊνικό οξύ το οποίον επίσης παρέχεται στο παρόν έγγραφο, μπορεί να χρησιμοποιηθεί για την παρασκευή ενός φαρμάκου, για παράδειγμα για την θεραπευτική αγωγή μιας κληρονομικής ασθένειας.
CY20161100724T 2000-09-21 2016-07-22 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα CY1117852T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00203283A EP1191097A1 (en) 2000-09-21 2000-09-21 Induction of exon skipping in eukaryotic cells
EP01979073A EP1320597A2 (en) 2000-09-21 2001-09-21 Induction of exon skipping in eukaryotic cells
EP13170245.8A EP2636741B1 (en) 2000-09-21 2001-09-21 Induction of exon skipping in eukaryotic cells

Publications (1)

Publication Number Publication Date
CY1117852T1 true CY1117852T1 (el) 2017-05-17

Family

ID=8172043

Family Applications (10)

Application Number Title Priority Date Filing Date
CY20081101494T CY1109601T1 (el) 2000-09-21 2008-12-23 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100207T CY1117521T1 (el) 2000-09-21 2016-03-10 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100215T CY1117522T1 (el) 2000-09-21 2016-03-11 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100216T CY1117318T1 (el) 2000-09-21 2016-03-11 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100443T CY1117887T1 (el) 2000-09-21 2016-05-23 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100724T CY1117852T1 (el) 2000-09-21 2016-07-22 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20171100302T CY1118972T1 (el) 2000-09-21 2017-03-09 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20171100691T CY1119026T1 (el) 2000-09-21 2017-06-29 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20171100750T CY1119088T1 (el) 2000-09-21 2017-07-14 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20181100969T CY1121139T1 (el) 2000-09-21 2018-09-19 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα

Family Applications Before (5)

Application Number Title Priority Date Filing Date
CY20081101494T CY1109601T1 (el) 2000-09-21 2008-12-23 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100207T CY1117521T1 (el) 2000-09-21 2016-03-10 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100215T CY1117522T1 (el) 2000-09-21 2016-03-11 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100216T CY1117318T1 (el) 2000-09-21 2016-03-11 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20161100443T CY1117887T1 (el) 2000-09-21 2016-05-23 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα

Family Applications After (4)

Application Number Title Priority Date Filing Date
CY20171100302T CY1118972T1 (el) 2000-09-21 2017-03-09 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20171100691T CY1119026T1 (el) 2000-09-21 2017-06-29 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20171100750T CY1119088T1 (el) 2000-09-21 2017-07-14 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα
CY20181100969T CY1121139T1 (el) 2000-09-21 2018-09-19 Επαγωγη παρακαμψης εξωνιου σε ευκαριωτικα κυτταρα

Country Status (17)

Country Link
US (6) US7973015B2 (el)
EP (14) EP1191097A1 (el)
JP (7) JP4846965B2 (el)
AT (1) ATE409224T2 (el)
AU (4) AU1106202A (el)
CA (1) CA2423044C (el)
CY (10) CY1109601T1 (el)
DE (1) DE60135936D1 (el)
DK (10) DK2602322T3 (el)
ES (11) ES2581285T3 (el)
HK (8) HK1184821A1 (el)
LT (3) LT2940139T (el)
NZ (1) NZ524853A (el)
PT (7) PT2636741E (el)
SI (1) SI2801618T1 (el)
TR (1) TR201810606T4 (el)
WO (1) WO2002024906A1 (el)

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AU2007234488A1 (en) 2007-12-06
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