BR9707529A - Oligunucleotìdeo especificamente hibridizável com dna ou rna. - Google Patents

Oligunucleotìdeo especificamente hibridizável com dna ou rna.

Info

Publication number
BR9707529A
BR9707529A BR9707529-9A BR9707529A BR9707529A BR 9707529 A BR9707529 A BR 9707529A BR 9707529 A BR9707529 A BR 9707529A BR 9707529 A BR9707529 A BR 9707529A
Authority
BR
Brazil
Prior art keywords
oligonucleotides
rna
dna
oligunucleotide
nucleoside units
Prior art date
Application number
BR9707529-9A
Other languages
English (en)
Inventor
Phillip D Cook
Brett P Monia
Karl Heinz Atmann
Pierre Martin
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of BR9707529A publication Critical patent/BR9707529A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"OLIGONUCLEOTìDEO ESPECIFICAMENTE HIBRIDIZáVEL COM DNA OU RNA". Esta invenção se dirige à síntese e uso de oligonucleotídeos para elicitar atividade RNase H para clivagem de filamentos em um filamento oposto. Estão incluídos na invenção os oligonucleotídeos em que pelo menso algumas das unidades de nuclesídeos dos oligonucleotídeos são funcionalizadas para serem resistentes a nuclease, pelo menos algumas das unidades de nucleosídeos dos oligonucleotídeos incluem um substituinte que potencia a hibridização de oligonucleotídeo para um filamento complementar de ácido nucleico, e pelo menos algumas das unidades de nucleosídeos dos oligonucleotídeos incluem porções de açúcar 2'- deoxi eritro-pentofuranosila.
BR9707529-9A 1996-02-14 1997-02-07 Oligunucleotìdeo especificamente hibridizável com dna ou rna. BR9707529A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1162096P 1996-02-14 1996-02-14
PCT/US1997/002043 WO1997030067A1 (en) 1996-02-14 1997-02-07 Sugar-modified gapped oligonucleotides

Publications (1)

Publication Number Publication Date
BR9707529A true BR9707529A (pt) 2000-01-04

Family

ID=21751248

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707529-9A BR9707529A (pt) 1996-02-14 1997-02-07 Oligunucleotìdeo especificamente hibridizável com dna ou rna.

Country Status (22)

Country Link
US (1) US6451991B1 (pt)
EP (1) EP0882061B1 (pt)
JP (1) JP4293636B2 (pt)
KR (1) KR19990082476A (pt)
CN (1) CN1214688A (pt)
AT (1) ATE267207T1 (pt)
AU (1) AU725262B2 (pt)
BR (1) BR9707529A (pt)
CA (2) CA2749312A1 (pt)
CZ (1) CZ243498A3 (pt)
DE (1) DE69729179T2 (pt)
DK (1) DK0882061T3 (pt)
ES (1) ES2221039T3 (pt)
HU (1) HUP9901118A3 (pt)
IL (1) IL125759A0 (pt)
NO (1) NO983718L (pt)
NZ (1) NZ331217A (pt)
PL (1) PL328563A1 (pt)
SK (1) SK109198A3 (pt)
TR (1) TR199801581T2 (pt)
WO (1) WO1997030067A1 (pt)
ZA (1) ZA971208B (pt)

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CN1214688A (zh) 1999-04-21
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HUP9901118A2 (hu) 1999-07-28
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KR19990082476A (ko) 1999-11-25
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