CY1117848T1 - Παραγωγα πολυμυξινης και χρησεις αυτων - Google Patents

Παραγωγα πολυμυξινης και χρησεις αυτων

Info

Publication number
CY1117848T1
CY1117848T1 CY20161100502T CY161100502T CY1117848T1 CY 1117848 T1 CY1117848 T1 CY 1117848T1 CY 20161100502 T CY20161100502 T CY 20161100502T CY 161100502 T CY161100502 T CY 161100502T CY 1117848 T1 CY1117848 T1 CY 1117848T1
Authority
CY
Cyprus
Prior art keywords
relates
present
polymyxin
derivative
gram
Prior art date
Application number
CY20161100502T
Other languages
Greek (el)
English (en)
Inventor
Martti Vaara
Timo Vaara
Original Assignee
Northern Antibiotics Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northern Antibiotics Oy filed Critical Northern Antibiotics Oy
Publication of CY1117848T1 publication Critical patent/CY1117848T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CY20161100502T 2006-08-11 2016-06-09 Παραγωγα πολυμυξινης και χρησεις αυτων CY1117848T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83742606P 2006-08-11 2006-08-11
DKPA200601055 2006-08-11
PCT/FI2007/050441 WO2008017734A1 (en) 2006-08-11 2007-08-10 Polymyxin derivatives and uses thereof

Publications (1)

Publication Number Publication Date
CY1117848T1 true CY1117848T1 (el) 2017-05-17

Family

ID=39032653

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100502T CY1117848T1 (el) 2006-08-11 2016-06-09 Παραγωγα πολυμυξινης και χρησεις αυτων

Country Status (21)

Country Link
EP (2) EP3078672A1 (enExample)
JP (1) JP5226685B2 (enExample)
KR (2) KR101502453B1 (enExample)
CN (2) CN103059106B (enExample)
AU (1) AU2007283514B2 (enExample)
BR (1) BRPI0715095B8 (enExample)
CA (1) CA2694289C (enExample)
CY (1) CY1117848T1 (enExample)
DK (1) DK2057185T3 (enExample)
ES (1) ES2575521T3 (enExample)
HR (1) HRP20160552T1 (enExample)
HU (1) HUE028271T2 (enExample)
IL (2) IL196693B (enExample)
MX (1) MX2009001398A (enExample)
NO (1) NO341982B1 (enExample)
NZ (1) NZ575421A (enExample)
PL (1) PL2057185T3 (enExample)
PT (1) PT2057185E (enExample)
RU (1) RU2455311C2 (enExample)
SI (1) SI2057185T1 (enExample)
WO (1) WO2008017734A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
HRP20220387T1 (hr) * 2014-03-11 2022-05-27 Spero Therapeutics, Inc. Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima
KR101664106B1 (ko) 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
DK3233105T3 (da) * 2014-12-18 2020-11-16 Helperby Therapeutics Ltd Hidtil ukendt kombination og anvendelse
FI126143B (en) * 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
CN104672307B (zh) * 2015-03-23 2017-09-29 吉林大学 一种提高阳离子短肽抗菌性和稳定性的方法
EP3072956A1 (en) * 2015-03-25 2016-09-28 Université de Fribourg Selective culture medium for polymyxin-resistant, gram-negative bacteria
FR3036406B1 (fr) 2015-05-20 2019-07-19 Biomerieux Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire
JP2018534303A (ja) 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators
WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
GB201703898D0 (en) 2017-03-10 2017-04-26 Helperby Therapeautics Ltd Method
GB201704620D0 (en) 2017-03-23 2017-05-10 Helperby Therapeautics Ltd Combinations
US11279733B2 (en) * 2017-11-02 2022-03-22 The University Of Queensland Peptide antibiotics
EP3560489A1 (en) * 2018-04-27 2019-10-30 European Molecular Biology Laboratory Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions
HRP20240028T1 (hr) 2018-06-25 2024-03-29 Spero Therapeutics, Inc. Spojevi
JP7469812B2 (ja) * 2018-07-19 2024-04-17 ノースイースタン ユニバーシティ 抗微生物特性を有する化合物
CN110179967A (zh) * 2019-05-28 2019-08-30 中国医药集团总公司四川抗菌素工业研究所 多粘菌素母核和一种抗生素的组合物及其应用
IT201900025414A1 (it) 2019-12-23 2021-06-23 Univ Bologna Alma Mater Studiorum Composto per il trattamento della sindrome emolitico uremica
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
CN118028503B (zh) * 2022-08-30 2024-08-09 四川大学华西医院 一类phoQ基因突变体、应用及其验证方法
WO2024123712A1 (en) * 2022-12-04 2024-06-13 Genentech, Inc. Analysis of candidate cytotoxic compositions
CN120399010B (zh) * 2025-07-01 2025-09-12 杭州肽佳生物科技有限公司 抗生素多粘菌素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450687A (en) 1966-02-24 1969-06-17 Pfizer & Co C Lower alkanoyl esters of polymyxin antibiotics
JPS4915537B1 (enExample) 1970-03-25 1974-04-16
BE754411A (fr) 1969-08-05 1971-02-04 Rhone Poulenc Sa Cyclopeptides derives des polymyxines et leur
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
MXPA03004437A (es) * 2000-11-20 2004-05-04 Daiichi Seiyaku Co Compuestos de deshalogeno.
WO2002055543A2 (en) 2001-01-16 2002-07-18 Univ Ramot Hybrid peptides for treatment of bacteremia and septicemia
ATE349223T1 (de) * 2002-03-01 2007-01-15 Chiesi Farma Spa Pharmazeutische zubereitungen mit verbesserten oberflächeneigenschaften welche ein lungen surfactant und ein polymyxin enthalten
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion

Also Published As

Publication number Publication date
PT2057185E (pt) 2016-06-17
JP5226685B2 (ja) 2013-07-03
CA2694289C (en) 2015-04-07
JP2010500331A (ja) 2010-01-07
EP3078672A1 (en) 2016-10-12
MX2009001398A (es) 2009-02-17
BRPI0715095B1 (pt) 2018-08-07
EP2057185A4 (en) 2009-08-19
DK2057185T3 (en) 2016-06-13
CN103059106B (zh) 2015-01-14
CN101501063A (zh) 2009-08-05
KR20090045932A (ko) 2009-05-08
BRPI0715095A2 (pt) 2013-10-15
NZ575421A (en) 2011-11-25
HUE028271T2 (en) 2016-12-28
BRPI0715095B8 (pt) 2021-05-25
HRP20160552T1 (hr) 2016-07-15
IL196693B (en) 2018-01-31
KR20150008198A (ko) 2015-01-21
WO2008017734A8 (en) 2009-07-30
NO341982B1 (no) 2018-03-05
RU2455311C2 (ru) 2012-07-10
CN101501063B (zh) 2014-03-12
CN103059106A (zh) 2013-04-24
IL196693A0 (en) 2009-11-18
CA2694289A1 (en) 2008-02-14
EP2057185B1 (en) 2016-05-11
NO20090674L (no) 2009-05-08
IL220270A0 (en) 2012-07-31
PL2057185T3 (pl) 2016-09-30
KR101502453B1 (ko) 2015-03-24
RU2009107857A (ru) 2010-09-20
EP2057185A1 (en) 2009-05-13
AU2007283514B2 (en) 2012-09-06
AU2007283514A1 (en) 2008-02-14
SI2057185T1 (sl) 2016-10-28
ES2575521T3 (es) 2016-06-29
WO2008017734A1 (en) 2008-02-14

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