CY1111631T1 - Παραγωγα των 7-αλκυνυλο-1,8- ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη - Google Patents

Παραγωγα των 7-αλκυνυλο-1,8- ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

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Publication number
CY1111631T1
CY1111631T1 CY20111100571T CY111100571T CY1111631T1 CY 1111631 T1 CY1111631 T1 CY 1111631T1 CY 20111100571 T CY20111100571 T CY 20111100571T CY 111100571 T CY111100571 T CY 111100571T CY 1111631 T1 CY1111631 T1 CY 1111631T1
Authority
CY
Cyprus
Prior art keywords
alkynyl
application
naphythyridones
therapeutics
preparation
Prior art date
Application number
CY20111100571T
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English (en)
Inventor
Antoine Alam
Sandrine Biscarrat
Isabelle Blanc
Françoise Bono
Olivier Duclos
Cort Gary Mc
Original Assignee
Sanofi-Aventis
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Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1111631T1 publication Critical patent/CY1111631T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Η εφεύρεση αφορά τα παράγωγα των 7- αλκυνυλο-1,8- ναφθυριδόνων του γενικού τύπου (I): όπου τα R1, R2, R3 και R4 είναι όπως ορίζονται στην περιγραφή. Διαδικασία παρασκευής και εφαρμογή στη θεραπευτική.
CY20111100571T 2007-06-13 2011-06-16 Παραγωγα των 7-αλκυνυλο-1,8- ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη CY1111631T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0704192A FR2917412B1 (fr) 2007-06-13 2007-06-13 Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
EP08826268A EP2158201B1 (fr) 2007-06-13 2008-06-11 Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CY1111631T1 true CY1111631T1 (el) 2015-10-07

Family

ID=38870275

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100571T CY1111631T1 (el) 2007-06-13 2011-06-16 Παραγωγα των 7-αλκυνυλο-1,8- ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

Country Status (45)

Country Link
US (1) US8470847B2 (el)
EP (1) EP2158201B1 (el)
JP (1) JP5343072B2 (el)
KR (1) KR101517636B1 (el)
CN (1) CN101679427B (el)
AP (1) AP2590A (el)
AR (1) AR066954A1 (el)
AT (1) ATE505469T1 (el)
AU (1) AU2008274099B2 (el)
BR (1) BRPI0814035B1 (el)
CA (1) CA2690337C (el)
CL (1) CL2008001775A1 (el)
CO (1) CO6150150A2 (el)
CR (1) CR11157A (el)
CY (1) CY1111631T1 (el)
DE (1) DE602008006188D1 (el)
DK (1) DK2158201T3 (el)
DO (1) DOP2009000264A (el)
EA (1) EA016939B1 (el)
EC (1) ECSP099791A (el)
ES (1) ES2365073T3 (el)
FR (1) FR2917412B1 (el)
GT (1) GT200900309A (el)
HK (1) HK1141790A1 (el)
HN (1) HN2009003402A (el)
HR (1) HRP20110515T1 (el)
IL (1) IL202640A (el)
JO (1) JO2682B1 (el)
MA (1) MA31567B1 (el)
ME (1) ME00961B (el)
MX (1) MX2009013515A (el)
MY (1) MY157754A (el)
NI (1) NI200900211A (el)
NZ (1) NZ581839A (el)
PA (1) PA8781701A1 (el)
PE (1) PE20090307A1 (el)
PL (1) PL2158201T3 (el)
PT (1) PT2158201E (el)
SI (1) SI2158201T1 (el)
SV (1) SV2009003429A (el)
TN (1) TN2009000483A1 (el)
TW (1) TWI405762B (el)
UA (1) UA96994C2 (el)
UY (1) UY31152A1 (el)
WO (1) WO2009007535A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2917413B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2952934B1 (fr) 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2954943B1 (fr) * 2010-01-07 2013-03-01 Sanofi Aventis Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
FR2965263A1 (fr) 2010-09-24 2012-03-30 Sanofi Aventis Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique
EP2524915A1 (en) * 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
JP5748210B2 (ja) * 2011-05-26 2015-07-15 日本化薬株式会社 複素環化合物の製造方法
WO2014012942A1 (en) * 2012-07-17 2014-01-23 Sanofi Use of vegfr-3 inhibitors for treating hepatocellular carcinoma
CN108558869B (zh) * 2018-05-10 2019-04-09 西安培华学院 用于治疗肝癌的化合物及其制剂
CN110981869A (zh) * 2019-12-10 2020-04-10 天津科技大学 一种1,8-双氮杂色酮的合成方法及其在抗糖尿病药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211965T3 (es) * 1995-08-02 2004-07-16 Darwin Discovery Limited Quinolonas y su utilizacion terapeutica.
HUP0002353A3 (en) * 1998-01-29 2001-11-28 Daiichi Asubio Pharma Co Ltd 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them
ES2247325T3 (es) * 2001-05-24 2006-03-01 MERCK FROSST CANADA & CO. Inhibidores de 1-biaril-1,8-naftiridin-4-ona fosfodiesterasa-4.
WO2005118587A1 (en) 2004-06-02 2005-12-15 Takeda Pharmaceutical Company Limited Indole derivative and use for treatment of cancer
FR2917413B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
UY31152A1 (es) 2009-01-30
PA8781701A1 (es) 2009-01-23
JP2010529178A (ja) 2010-08-26
DOP2009000264A (es) 2009-12-15
CL2008001775A1 (es) 2009-09-25
TWI405762B (zh) 2013-08-21
WO2009007535A2 (fr) 2009-01-15
AP2590A (en) 2013-02-04
HN2009003402A (es) 2012-02-27
FR2917412B1 (fr) 2009-08-21
HRP20110515T1 (hr) 2011-08-31
CR11157A (es) 2010-03-23
TN2009000483A1 (fr) 2011-03-31
MY157754A (en) 2016-07-15
AU2008274099A1 (en) 2009-01-15
IL202640A0 (en) 2010-06-30
DK2158201T3 (da) 2011-08-01
AP2010005099A0 (en) 2010-02-28
JO2682B1 (en) 2013-03-03
PE20090307A1 (es) 2009-04-20
EP2158201A2 (fr) 2010-03-03
CN101679427A (zh) 2010-03-24
BRPI0814035A2 (pt) 2020-08-04
JP5343072B2 (ja) 2013-11-13
KR101517636B1 (ko) 2015-05-04
AU2008274099B2 (en) 2013-05-16
ECSP099791A (es) 2010-01-29
PL2158201T3 (pl) 2011-09-30
EA201070009A1 (ru) 2010-06-30
DE602008006188D1 (de) 2011-05-26
MX2009013515A (es) 2010-01-27
AR066954A1 (es) 2009-09-23
UA96994C2 (ru) 2011-12-26
BRPI0814035B1 (pt) 2021-10-26
EA016939B1 (ru) 2012-08-30
PT2158201E (pt) 2011-07-05
KR20100020000A (ko) 2010-02-19
HK1141790A1 (el) 2010-11-19
ME00961B (me) 2012-06-20
CA2690337A1 (fr) 2009-01-15
CO6150150A2 (es) 2010-04-20
CA2690337C (fr) 2015-08-11
WO2009007535A3 (fr) 2009-04-09
IL202640A (en) 2014-01-30
MA31567B1 (fr) 2010-08-02
ES2365073T3 (es) 2011-09-21
ATE505469T1 (de) 2011-04-15
EP2158201B1 (fr) 2011-04-13
NI200900211A (es) 2010-07-15
SV2009003429A (es) 2010-02-05
TW200911802A (en) 2009-03-16
GT200900309A (es) 2012-01-26
CN101679427B (zh) 2013-02-20
NZ581839A (en) 2011-05-27
FR2917412A1 (fr) 2008-12-19
SI2158201T1 (sl) 2011-07-29
US8470847B2 (en) 2013-06-25
US20100144757A1 (en) 2010-06-10

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