CY1113129T1 - Παραγωγα 5,6-δισαρυλ-2- πυριδινο- καρβοξαμιδιου, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ανταγωνιστες των υποδοχεων ουροτενσινης ii - Google Patents

Παραγωγα 5,6-δισαρυλ-2- πυριδινο- καρβοξαμιδιου, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ανταγωνιστες των υποδοχεων ουροτενσινης ii

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Publication number
CY1113129T1
CY1113129T1 CY20121100607T CY121100607T CY1113129T1 CY 1113129 T1 CY1113129 T1 CY 1113129T1 CY 20121100607 T CY20121100607 T CY 20121100607T CY 121100607 T CY121100607 T CY 121100607T CY 1113129 T1 CY1113129 T1 CY 1113129T1
Authority
CY
Cyprus
Prior art keywords
preparation
application
dissaryl
competitives
pyridin
Prior art date
Application number
CY20121100607T
Other languages
English (en)
Inventor
Jean-Michel Altenburger
Valérie FOSSEY
Gilbert Lassalle
Frédéric PETIT
Jean-Claude Vernieres
Philip Janiak
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1113129T1 publication Critical patent/CY1113129T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

Η εφεύρεση αφορά ενώσεις που αφορούν τον τύπου (Ι): όπου τα Χ, Υ, U, Α, Β, W, Ζ, R1 και R2 είναι όπως ορίζονται στην περιγραφή. Διαδικασία παρασκευής και εφαρμογής στη θεραπευτική.
CY20121100607T 2006-08-11 2012-07-09 Παραγωγα 5,6-δισαρυλ-2- πυριδινο- καρβοξαμιδιου, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ανταγωνιστες των υποδοχεων ουροτενσινης ii CY1113129T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0607283A FR2904827B1 (fr) 2006-08-11 2006-08-11 Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
EP07823409A EP2059508B1 (fr) 2006-08-11 2007-08-09 Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii

Publications (1)

Publication Number Publication Date
CY1113129T1 true CY1113129T1 (el) 2016-04-13

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CY20121100607T CY1113129T1 (el) 2006-08-11 2012-07-09 Παραγωγα 5,6-δισαρυλ-2- πυριδινο- καρβοξαμιδιου, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ανταγωνιστες των υποδοχεων ουροτενσινης ii

Country Status (38)

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US (2) US8110579B2 (el)
EP (2) EP2439193B1 (el)
JP (1) JP5230621B2 (el)
KR (1) KR20090050075A (el)
CN (1) CN101511789B (el)
AR (1) AR062294A1 (el)
AT (1) ATE553082T1 (el)
AU (1) AU2007285659B2 (el)
BR (1) BRPI0716655A2 (el)
CA (1) CA2659928A1 (el)
CL (1) CL2007002329A1 (el)
CO (1) CO6150147A2 (el)
CR (1) CR10603A (el)
CY (1) CY1113129T1 (el)
DK (1) DK2059508T3 (el)
EA (1) EA016352B1 (el)
ES (1) ES2385614T3 (el)
FR (1) FR2904827B1 (el)
GT (1) GT200900026A (el)
HK (1) HK1135903A1 (el)
HR (1) HRP20120559T1 (el)
IL (1) IL196797A (el)
MA (1) MA30703B1 (el)
MX (1) MX2009001582A (el)
MY (1) MY145644A (el)
NO (1) NO20090779L (el)
NZ (1) NZ574699A (el)
PE (1) PE20080421A1 (el)
PL (1) PL2059508T3 (el)
PT (1) PT2059508E (el)
RS (1) RS52420B (el)
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FR2948119A1 (fr) * 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
FR2948120A1 (fr) 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyrimidine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l’urotensine ii
AR079022A1 (es) * 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
CN104837832B (zh) * 2012-10-05 2019-04-26 里格尔药品股份有限公司 Gdf-8抑制剂
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
CN105228997B (zh) 2013-03-15 2018-03-27 Epizyme股份有限公司 Carm1抑制剂及其用途
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SG187993A1 (en) 2013-03-28
RS52420B (en) 2013-02-28
ATE553082T1 (de) 2012-04-15
MA30703B1 (fr) 2009-09-01
HRP20120559T1 (hr) 2012-07-31
SI2059508T1 (sl) 2012-08-31
CN101511789A (zh) 2009-08-19
AU2007285659B2 (en) 2013-01-10
FR2904827A1 (fr) 2008-02-15
JP5230621B2 (ja) 2013-07-10
AU2007285659A1 (en) 2008-02-21
US8552201B2 (en) 2013-10-08
PL2059508T3 (pl) 2012-09-28
IL196797A0 (en) 2009-11-18
EP2439193A1 (fr) 2012-04-11
HK1135903A1 (el) 2010-06-18
CN101511789B (zh) 2012-05-23
KR20090050075A (ko) 2009-05-19
WO2008020124A1 (fr) 2008-02-21
EP2059508B1 (fr) 2012-04-11
EA016352B1 (ru) 2012-04-30
CL2007002329A1 (es) 2008-03-07
TWI388551B (zh) 2013-03-11
US20090318473A1 (en) 2009-12-24
PE20080421A1 (es) 2008-06-17
FR2904827B1 (fr) 2008-09-19
NZ574699A (en) 2011-10-28
AR062294A1 (es) 2008-10-29
GT200900026A (es) 2009-11-24
DK2059508T3 (da) 2012-07-23
ZA200900835B (en) 2010-06-30
EP2439193B1 (fr) 2014-04-23
US8110579B2 (en) 2012-02-07
JP2010500332A (ja) 2010-01-07
EP2059508A1 (fr) 2009-05-20
CO6150147A2 (es) 2010-04-20
TN2009000040A1 (en) 2010-08-19
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TW200815393A (en) 2008-04-01
MY145644A (en) 2012-03-15
UY30534A1 (es) 2008-03-31
CA2659928A1 (fr) 2008-02-21
MX2009001582A (es) 2009-02-19
EA200970192A1 (ru) 2009-08-28
IL196797A (en) 2013-07-31
NO20090779L (no) 2009-05-05
CR10603A (es) 2009-07-03
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