CY1114793T1 - Παραγωγα αμινοπυραζολιου - Google Patents

Παραγωγα αμινοπυραζολιου

Info

Publication number
CY1114793T1
CY1114793T1 CY20131101025T CY131101025T CY1114793T1 CY 1114793 T1 CY1114793 T1 CY 1114793T1 CY 20131101025 T CY20131101025 T CY 20131101025T CY 131101025 T CY131101025 T CY 131101025T CY 1114793 T1 CY1114793 T1 CY 1114793T1
Authority
CY
Cyprus
Prior art keywords
derivatives
aminoprazole
formula
preparation
description
Prior art date
Application number
CY20131101025T
Other languages
English (en)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Heinz Fretz
Corinna Grisostomi
Xavier Leroy
Julien Pothier
Sylvia Richard-Bildstein
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1114793T1 publication Critical patent/CY1114793T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Η εφεύρεση αφορά σε νέα παράγωγα αμινοπυραζολίου του τύπου (Ι), όπου τα Α, Ε R1 και R2 έχουν όπως ορίζεται στην περιγραφή, στην παρασκευή και στη χρήση τους ως φαρμακευτικά δραστικές ενώσεις.
CY20131101025T 2007-12-14 2013-11-20 Παραγωγα αμινοπυραζολιου CY1114793T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2007055111 2007-12-14
IB2008053648 2008-09-10
EP08862120.6A EP2242743B1 (en) 2007-12-14 2008-12-12 Aminopyrazole derivatives

Publications (1)

Publication Number Publication Date
CY1114793T1 true CY1114793T1 (el) 2016-12-14

Family

ID=40456559

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101025T CY1114793T1 (el) 2007-12-14 2013-11-20 Παραγωγα αμινοπυραζολιου

Country Status (25)

Country Link
US (1) US8288419B2 (el)
EP (1) EP2242743B1 (el)
JP (1) JP5435744B2 (el)
KR (1) KR101622413B1 (el)
CN (1) CN101903353B (el)
AR (1) AR069650A1 (el)
BR (1) BRPI0821004A8 (el)
CA (1) CA2706836C (el)
CY (1) CY1114793T1 (el)
DK (1) DK2242743T3 (el)
ES (1) ES2432059T3 (el)
HK (1) HK1148286A1 (el)
HR (1) HRP20131105T1 (el)
IL (1) IL206296A (el)
MA (1) MA31988B1 (el)
MX (1) MX2010005827A (el)
MY (1) MY153921A (el)
NZ (1) NZ586776A (el)
PL (1) PL2242743T3 (el)
PT (1) PT2242743E (el)
RU (1) RU2489426C2 (el)
SI (1) SI2242743T1 (el)
TW (1) TWI430795B (el)
WO (1) WO2009077954A1 (el)
ZA (1) ZA201004939B (el)

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DK2225231T3 (da) 2007-12-18 2011-10-17 Actelion Pharmaceuticals Ltd Aminotriazolderivater som alx-agonister
NZ597122A (en) 2009-05-18 2013-06-28 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
AU2010258334B2 (en) 2009-06-09 2015-02-26 Idorsia Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
CN102803237B (zh) * 2009-06-12 2014-09-24 埃科特莱茵药品有限公司 作为alx受体激动剂的噁唑和噻唑衍生物
PE20130405A1 (es) 2010-04-07 2013-04-10 Hoffmann La Roche Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso
KR101905927B1 (ko) 2010-11-17 2018-10-08 이도르시아 파마슈티컬스 리미티드 가교된 스피로［２．４］헵탄 에스테르 유도체
AU2011340103A1 (en) * 2010-12-07 2013-07-25 Actelion Pharmaceuticals Ltd. Hydroxylated aminotriazole derivatives as ALX receptor agonists
PL2649068T3 (pl) * 2010-12-07 2015-03-31 Idorsia Pharmaceuticals Ltd Pochodne eteru oksazolilowo-metylowego jako agoniści receptora ALX
WO2012110986A1 (en) 2011-02-18 2012-08-23 Actelion Pharmaceuticals Ltd Novel pyrazole and imidazole derivatives useful as orexin antagonists
US20140113824A1 (en) 2011-05-10 2014-04-24 Bayer Intellectual Property Gmbh Bicyclic (thio)carbonylamidines
MX2014003612A (es) 2011-09-27 2014-07-09 Hoffmann La Roche Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso.
DE102011055815A1 (de) 2011-11-29 2013-05-29 Aicuris Gmbh & Co. Kg Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
CN104284887B (zh) 2012-05-16 2016-06-22 埃科特莱茵药品有限公司 作为alx受体激动剂的经1-(对-甲苯基)环丙基取代的桥联螺[2.4]庚烷衍生物
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
EP3022188B1 (en) 2013-07-18 2017-06-07 Actelion Pharmaceuticals Ltd Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
CA2932010C (en) 2013-11-28 2020-07-07 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
BR112017024966A2 (pt) 2015-05-27 2018-08-07 Kyorin Seiyaku Kk derivado de ureia ou sal farmacologicamente aceitável do mesmo
US10858314B2 (en) 2015-05-27 2020-12-08 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
KR20200128709A (ko) 2018-03-05 2020-11-16 브리스톨-마이어스 스큅 컴퍼니 페닐피롤리디논 포르밀 펩티드 2 수용체 효능제
IL277794B2 (en) * 2018-04-06 2024-02-01 Black Belt Tx Ltd ATF6 inhibitors and uses thereof
WO2023118434A1 (en) * 2021-12-22 2023-06-29 Globachem Nv Pesticidally active amide compounds

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GB8531019D0 (en) * 1985-12-17 1986-01-29 Beecham Group Plc Compounds
JPS62234018A (ja) 1986-04-02 1987-10-14 Rooto Seiyaku Kk 糖尿病併発症治療剤
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DK2225231T3 (da) 2007-12-18 2011-10-17 Actelion Pharmaceuticals Ltd Aminotriazolderivater som alx-agonister
NZ597122A (en) 2009-05-18 2013-06-28 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
AU2010258334B2 (en) 2009-06-09 2015-02-26 Idorsia Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
CN102803237B (zh) 2009-06-12 2014-09-24 埃科特莱茵药品有限公司 作为alx受体激动剂的噁唑和噻唑衍生物

Also Published As

Publication number Publication date
HK1148286A1 (en) 2011-09-02
RU2010128240A (ru) 2012-01-20
HRP20131105T1 (hr) 2013-12-20
BRPI0821004A2 (pt) 2015-06-16
SI2242743T1 (sl) 2013-11-29
CN101903353B (zh) 2013-04-10
IL206296A (en) 2015-03-31
EP2242743A1 (en) 2010-10-27
JP5435744B2 (ja) 2014-03-05
MY153921A (en) 2015-04-15
AU2008337151A1 (en) 2009-06-25
MX2010005827A (es) 2010-06-11
US20110034516A1 (en) 2011-02-10
KR101622413B1 (ko) 2016-05-18
US8288419B2 (en) 2012-10-16
RU2489426C2 (ru) 2013-08-10
PT2242743E (pt) 2013-10-28
TWI430795B (zh) 2014-03-21
EP2242743B1 (en) 2013-08-21
IL206296A0 (en) 2010-12-30
KR20100098557A (ko) 2010-09-07
TW200924753A (en) 2009-06-16
MA31988B1 (fr) 2011-01-03
NZ586776A (en) 2012-06-29
AR069650A1 (es) 2010-02-10
BRPI0821004A8 (pt) 2017-12-26
JP2011506424A (ja) 2011-03-03
CA2706836C (en) 2016-05-17
ZA201004939B (en) 2012-12-27
WO2009077954A1 (en) 2009-06-25
CA2706836A1 (en) 2009-06-25
DK2242743T3 (da) 2013-10-14
CN101903353A (zh) 2010-12-01
PL2242743T3 (pl) 2014-01-31
ES2432059T3 (es) 2013-11-29

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