NO20090674L - Polymyxin derivater og anvendelser derav - Google Patents
Polymyxin derivater og anvendelser deravInfo
- Publication number
- NO20090674L NO20090674L NO20090674A NO20090674A NO20090674L NO 20090674 L NO20090674 L NO 20090674L NO 20090674 A NO20090674 A NO 20090674A NO 20090674 A NO20090674 A NO 20090674A NO 20090674 L NO20090674 L NO 20090674L
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- present
- derivatives
- relates
- polymyxin
- Prior art date
Links
- 108010040201 Polymyxins Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 3
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 206010029155 Nephropathy toxic Diseases 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000008260 defense mechanism Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000007694 nephrotoxicity Effects 0.000 abstract 1
- 231100000417 nephrotoxicity Toxicity 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940041153 polymyxins Drugs 0.000 abstract 1
- 230000001235 sensitizing effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Foreliggende oppfinnelse gjelder et polymyksinderivat i hvilket R1, R2 og R3 er valgfrie og R1, R2, R3, R5, R8 og R9 er kationiske eller nøytrale aminosyrerester som er utvalgt slik at det totale antall positive ladninger ved fysiologisk pH er minst to, men ikke mer enn tre, og et kombinasjonsprodukt som omfatter minst to slike derivater. Oppfinnelsen gjelder videre en fremgangsmåte for behandling, lindring eller fjerning av en infeksjon i et individ som skyldes en gram negativ bakterie ved tilførsel av en terapeutisk effektiv mengde av et derivat ifølge foreliggende oppfinnelse til individet, en fremgangsmåte for sensitivisering av gram negative bakterier overfor antibakterielt middel ved samtidig eller sekvensiell i hvilken som helst rekkefølge tilførsel av en terapeutisk effektiv mengde av det antibakterielle middel og et derivat ifølge foreliggende oppfinnelse til individet, fremgangsmåte for utvikling i antibiotika, for reduksjon av nefrotoksisiteten, for å forbedre de farmakokin etiske egenskapene til naturlige polymyksiner og oktapeptiner og for sensitivisering av klinisk viktige bakterier overfor en komplementbasert vertsforsvarsmekanisme som foreligger i serum. Endelig gjelder oppfinnelsen en fremgangsmåte for fremstilli ng av slike polymyksinderivater.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83742606P | 2006-08-11 | 2006-08-11 | |
| DKPA200601055 | 2006-08-11 | ||
| PCT/FI2007/050441 WO2008017734A1 (en) | 2006-08-11 | 2007-08-10 | Polymyxin derivatives and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20090674L true NO20090674L (no) | 2009-05-08 |
| NO341982B1 NO341982B1 (no) | 2018-03-05 |
Family
ID=39032653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20090674A NO341982B1 (no) | 2006-08-11 | 2009-02-12 | Polymyxin derivater og anvendelser derav |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP3078672A1 (no) |
| JP (1) | JP5226685B2 (no) |
| KR (2) | KR20150008198A (no) |
| CN (2) | CN101501063B (no) |
| AU (1) | AU2007283514B2 (no) |
| BR (1) | BRPI0715095B8 (no) |
| CA (1) | CA2694289C (no) |
| CY (1) | CY1117848T1 (no) |
| DK (1) | DK2057185T3 (no) |
| ES (1) | ES2575521T3 (no) |
| HR (1) | HRP20160552T1 (no) |
| HU (1) | HUE028271T2 (no) |
| IL (2) | IL196693B (no) |
| MX (1) | MX2009001398A (no) |
| NO (1) | NO341982B1 (no) |
| NZ (1) | NZ575421A (no) |
| PL (1) | PL2057185T3 (no) |
| PT (1) | PT2057185E (no) |
| RU (1) | RU2455311C2 (no) |
| SI (1) | SI2057185T1 (no) |
| WO (1) | WO2008017734A1 (no) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| AR074874A1 (es) | 2008-12-23 | 2011-02-16 | Biosource Pharm Inc | Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto. |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) * | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| EP2780357A1 (en) * | 2011-11-18 | 2014-09-24 | Novacta Biosystems Limited | Polymyxin derivatives |
| WO2014188178A1 (en) * | 2013-05-22 | 2014-11-27 | Cantab Anti-Infectives Limited | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
| KR20230152779A (ko) * | 2014-03-11 | 2023-11-03 | 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 |
| KR101664106B1 (ko) | 2014-09-11 | 2016-10-10 | 한국화학연구원 | 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물 |
| AU2015352440B2 (en) * | 2014-11-26 | 2020-02-06 | Spero Therapeutics, Inc. | Compounds |
| CN107257803B (zh) | 2014-12-16 | 2021-02-05 | 上海盟科药业股份有限公司 | 用于治疗细菌感染的多粘菌素类抗菌剂 |
| US10335454B2 (en) * | 2014-12-18 | 2019-07-02 | Helperby Therapeutics Limited | Combination and use |
| FI126143B (en) * | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| CN104672307B (zh) * | 2015-03-23 | 2017-09-29 | 吉林大学 | 一种提高阳离子短肽抗菌性和稳定性的方法 |
| EP3072956A1 (en) * | 2015-03-25 | 2016-09-28 | Université de Fribourg | Selective culture medium for polymyxin-resistant, gram-negative bacteria |
| FR3036406B1 (fr) | 2015-05-20 | 2019-07-19 | Biomerieux | Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire |
| WO2017083859A1 (en) * | 2015-11-12 | 2017-05-18 | The Trustees Of Columbia University In The City Of New York | Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics |
| WO2017189866A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Polymyxin analogs useful as antibiotic potentiators |
| WO2017189868A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Serine replacement polymyxin analogues useful as antibiotic potentiators |
| GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
| GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
| JP2021501783A (ja) * | 2017-11-02 | 2021-01-21 | ザ ユニバーシティー オブ クイーンズランド | ペプチド抗生物質 |
| EP3560489A1 (en) * | 2018-04-27 | 2019-10-30 | European Molecular Biology Laboratory | Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions |
| HRP20240028T1 (hr) | 2018-06-25 | 2024-03-29 | Spero Therapeutics, Inc. | Spojevi |
| CN112739710B (zh) * | 2018-07-19 | 2024-08-27 | 东北大学 | 具有抗菌特性的化合物 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| US20230141981A1 (en) | 2020-01-21 | 2023-05-11 | Shanghai Micurx Pharmaceuticals Co., Ltd | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| CN118028504B (zh) * | 2022-08-30 | 2024-08-02 | 四川大学华西医院 | 一类phoQ基因突变体、应用及其验证方法 |
| WO2024123712A1 (en) * | 2022-12-04 | 2024-06-13 | Genentech, Inc. | Analysis of candidate cytotoxic compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450687A (en) | 1966-02-24 | 1969-06-17 | Pfizer & Co C | Lower alkanoyl esters of polymyxin antibiotics |
| JPS4915537B1 (no) | 1970-03-25 | 1974-04-16 | ||
| BE754411A (fr) | 1969-08-05 | 1971-02-04 | Rhone Poulenc Sa | Cyclopeptides derives des polymyxines et leur |
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| US20040063754A1 (en) * | 2000-11-20 | 2004-04-01 | Hisashi Takahashi | Dehalogeno compounds |
| DE60239316D1 (de) | 2001-01-16 | 2011-04-14 | Univ Ramot | Hybridpeptide für die behandlung von bacteraemie und sepsis |
| SI1340506T1 (sl) * | 2002-03-01 | 2007-04-30 | Chiesi Farma Spa | Sestavki, ki vsebujejo pljucne surfaktante in polimiksin z izboljsanimi povrsinskimi lastnostmi |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
-
2007
- 2007-08-10 HU HUE07803704A patent/HUE028271T2/en unknown
- 2007-08-10 PL PL07803704.1T patent/PL2057185T3/pl unknown
- 2007-08-10 MX MX2009001398A patent/MX2009001398A/es active IP Right Grant
- 2007-08-10 DK DK07803704.1T patent/DK2057185T3/en active
- 2007-08-10 NZ NZ575421A patent/NZ575421A/en not_active IP Right Cessation
- 2007-08-10 WO PCT/FI2007/050441 patent/WO2008017734A1/en active Application Filing
- 2007-08-10 BR BRPI0715095A patent/BRPI0715095B8/pt not_active IP Right Cessation
- 2007-08-10 JP JP2009523312A patent/JP5226685B2/ja active Active
- 2007-08-10 EP EP16168287.7A patent/EP3078672A1/en not_active Withdrawn
- 2007-08-10 ES ES07803704.1T patent/ES2575521T3/es active Active
- 2007-08-10 RU RU2009107857/04A patent/RU2455311C2/ru active
- 2007-08-10 PT PT07803704T patent/PT2057185E/pt unknown
- 2007-08-10 SI SI200731783A patent/SI2057185T1/sl unknown
- 2007-08-10 CN CN200780029855.5A patent/CN101501063B/zh not_active Expired - Fee Related
- 2007-08-10 CN CN201310011979.8A patent/CN103059106B/zh not_active Expired - Fee Related
- 2007-08-10 EP EP07803704.1A patent/EP2057185B1/en active Active
- 2007-08-10 KR KR1020147036680A patent/KR20150008198A/ko not_active Application Discontinuation
- 2007-08-10 KR KR1020097004841A patent/KR101502453B1/ko active IP Right Grant
- 2007-08-10 AU AU2007283514A patent/AU2007283514B2/en not_active Ceased
- 2007-08-10 CA CA 2694289 patent/CA2694289C/en active Active
-
2009
- 2009-01-22 IL IL196693A patent/IL196693B/en active IP Right Grant
- 2009-02-12 NO NO20090674A patent/NO341982B1/no unknown
-
2012
- 2012-06-07 IL IL220270A patent/IL220270A0/en unknown
-
2016
- 2016-05-23 HR HRP20160552TT patent/HRP20160552T1/hr unknown
- 2016-06-09 CY CY20161100502T patent/CY1117848T1/el unknown
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