NO20092542L - Antibakterielle kinolin-derivater - Google Patents

Antibakterielle kinolin-derivater

Info

Publication number
NO20092542L
NO20092542L NO20092542A NO20092542A NO20092542L NO 20092542 L NO20092542 L NO 20092542L NO 20092542 A NO20092542 A NO 20092542A NO 20092542 A NO20092542 A NO 20092542A NO 20092542 L NO20092542 L NO 20092542L
Authority
NO
Norway
Prior art keywords
quinoline derivatives
pharmaceutically acceptable
treatment
bacterial infection
compounds
Prior art date
Application number
NO20092542A
Other languages
English (en)
Other versions
NO341983B1 (no
Inventor
Jerome Emile Georges Guillemont
Koenraad Jozef Lodewij Andries
Anil Koul
Ismet Dorange
David Francis Alain Lanceois
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38126091&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20092542(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20092542L publication Critical patent/NO20092542L/no
Publication of NO341983B1 publication Critical patent/NO341983B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Den foreliggende oppfinnelsen angår nye substituerte kinolinderivater ifølge den generelle Formel (Ia) eller Formel (Ib): inkludert enhver stereokjemisk isomerform derav, et N-oksid derav, et farmasøytisk akseptabelt salt derav eller et solvat derav. De krevde forbindelsene er nyttige i behandlingen av en bakteriell infeksjon. Også krevet er en sammensetning omfattende en farmasøytisk akseptabel bærer og, som aktiv ingrediens, en terapeutisk effektiv mengde av de krevde forbindelsene, anvendelsen av de krevde forbindelsene eller sammensetninger for fremstillingen av et medikament for behandlingen av en bakteriell infeksjon og en fremgangsmåte for å fremstille de krevde forbindelsene.
NO20092542A 2006-12-06 2009-07-06 Antibakterielle kinolin-derivater NO341983B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125499 2006-12-06
PCT/EP2007/063313 WO2008068267A1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
NO20092542L true NO20092542L (no) 2009-08-25
NO341983B1 NO341983B1 (no) 2018-03-05

Family

ID=38126091

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092542A NO341983B1 (no) 2006-12-06 2009-07-06 Antibakterielle kinolin-derivater

Country Status (33)

Country Link
US (1) US8415475B2 (no)
EP (1) EP2099758B1 (no)
JP (1) JP5466011B2 (no)
KR (1) KR101490222B1 (no)
CN (2) CN104744361B (no)
AP (1) AP2479A (no)
AR (1) AR064151A1 (no)
AU (1) AU2007328887B2 (no)
BR (1) BRPI0720220B8 (no)
CA (1) CA2669819C (no)
CL (1) CL2007003514A1 (no)
CY (1) CY1117766T1 (no)
DK (1) DK2099758T3 (no)
EA (1) EA016733B1 (no)
ES (1) ES2573689T3 (no)
HK (1) HK1208437A1 (no)
HR (1) HRP20160585T1 (no)
HU (1) HUE028769T2 (no)
IL (1) IL199083A (no)
JO (1) JO3271B1 (no)
ME (1) ME02498B (no)
MX (1) MX2009005978A (no)
MY (1) MY181645A (no)
NO (1) NO341983B1 (no)
NZ (1) NZ576823A (no)
PL (1) PL2099758T3 (no)
PT (1) PT2099758E (no)
RS (1) RS54794B1 (no)
SI (1) SI2099758T1 (no)
TW (1) TWI406659B (no)
UA (1) UA100972C2 (no)
WO (1) WO2008068267A1 (no)
ZA (1) ZA200903950B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2841425T3 (pl) 2012-04-27 2016-10-31 Antybakteryjne pochodne chinoliny
EA038350B1 (ru) 2012-04-27 2021-08-12 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
AR093017A1 (es) 2012-10-16 2015-05-13 Janssen Pharmaceutica Nv MODULARES DE RORgT DE QUINOLINILO UNIDOS POR METILENO
BR112015008515A2 (pt) 2012-10-16 2017-07-04 Janssen Pharmaceutica Nv moduladores de ror t de quinolinila ligada à heteroarila
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
CA2954872C (en) 2014-07-14 2019-08-13 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
MX2017009681A (es) * 2015-01-27 2017-10-18 Janssen Pharmaceutica Nv Composiciones dispersables.
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN105601566A (zh) * 2016-02-02 2016-05-25 张敏 一种护理烧伤后感染的药物组合物
ES2934785T3 (es) 2016-03-07 2023-02-27 The Global Alliance For Tb Drug Dev Inc Compuestos antibacterianos y usos de los mismos
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
JP2021511364A (ja) * 2018-01-29 2021-05-06 カディラ ヘルスケア リミティド 抗菌剤として有用な複素環式化合物
JP2023547108A (ja) * 2020-10-22 2023-11-09 ルネラ・バイオテック・インコーポレーテッド γサブユニットを標的とするミトコンドリアＡＴＰ阻害剤は転移を予防する

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (en) 1996-10-28 2001-04-11 Dept Of The Army Us Government COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS
RS52431B (en) * 2002-07-25 2013-02-28 Janssen Pharmaceutica N.V. QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS
NZ547277A (en) 2004-01-23 2009-08-28 Janssen Pharmaceutica Nv Substituted quinolines and their use as mycobacterial inhibitors
US7902225B2 (en) 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
JP4919810B2 (ja) * 2004-01-29 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイコバクテリア抑制剤としての使用のためのキノリン誘導体
CN102908347A (zh) * 2004-05-28 2013-02-06 詹森药业有限公司 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途
PT1797115T (pt) 2004-09-28 2017-08-29 Janssen Pharmaceutica Nv Domínio de ligação de atp-sintase bacteriana
EE05394B1 (et) 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents

Also Published As

Publication number Publication date
EA200970535A1 (ru) 2009-10-30
EA016733B1 (ru) 2012-07-30
WO2008068267A1 (en) 2008-06-12
HUE028769T2 (en) 2017-01-30
BRPI0720220B8 (pt) 2021-05-25
TW200838528A (en) 2008-10-01
JP2010511668A (ja) 2010-04-15
PT2099758E (pt) 2016-06-02
BRPI0720220B1 (pt) 2020-06-09
EP2099758A1 (en) 2009-09-16
US8415475B2 (en) 2013-04-09
AU2007328887A1 (en) 2008-06-12
DK2099758T3 (en) 2016-06-13
CN101553470A (zh) 2009-10-07
KR101490222B1 (ko) 2015-02-05
JP5466011B2 (ja) 2014-04-09
CA2669819C (en) 2016-08-30
UA100972C2 (ru) 2013-02-25
TWI406659B (zh) 2013-09-01
ES2573689T3 (es) 2016-06-09
CY1117766T1 (el) 2017-05-17
ZA200903950B (en) 2010-08-25
KR20090086604A (ko) 2009-08-13
CN104744361B (zh) 2021-06-08
AP2009004874A0 (en) 2009-06-30
MX2009005978A (es) 2009-06-16
CA2669819A1 (en) 2008-06-12
HRP20160585T1 (hr) 2016-06-17
JO3271B1 (ar) 2018-09-16
AR064151A1 (es) 2009-03-18
PL2099758T3 (pl) 2016-08-31
ME02498B (me) 2017-02-20
BRPI0720220A2 (pt) 2013-12-24
AU2007328887B2 (en) 2013-01-17
MY181645A (en) 2020-12-30
CN104744361A (zh) 2015-07-01
HK1208437A1 (en) 2016-03-04
NZ576823A (en) 2012-01-12
IL199083A (en) 2014-08-31
IL199083A0 (en) 2010-03-28
US20100048566A1 (en) 2010-02-25
AP2479A (en) 2012-09-27
EP2099758B1 (en) 2016-03-09
CL2007003514A1 (es) 2008-07-11
NO341983B1 (no) 2018-03-05
SI2099758T1 (sl) 2016-07-29
RS54794B1 (sr) 2016-10-31

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