MX2009005978A - Derivados de quinolina antibacterianos. - Google Patents

Derivados de quinolina antibacterianos.

Info

Publication number
MX2009005978A
MX2009005978A MX2009005978A MX2009005978A MX2009005978A MX 2009005978 A MX2009005978 A MX 2009005978A MX 2009005978 A MX2009005978 A MX 2009005978A MX 2009005978 A MX2009005978 A MX 2009005978A MX 2009005978 A MX2009005978 A MX 2009005978A
Authority
MX
Mexico
Prior art keywords
compounds
quinoline derivatives
pharmaceutically acceptable
treatment
bacterial infection
Prior art date
Application number
MX2009005978A
Other languages
English (en)
Inventor
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Jerome Emile Georges Guillemont
Ismet Dorange
David Francis Alain Lancois
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38126091&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005978(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2009005978A publication Critical patent/MX2009005978A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con novedosos derivados de quinolina sustituida de conformidad con la fórmula general (la) o la fórmula (Ib): (ver fórmulas Ia Ib) incluyendo cualquier forma estereoquímicamente isomérica de los mismos, un N-óxido de los mismos, una sal aceptable para uso farmacéutico de los mismos o un solvato de los mismos; los compuestos reivindicados son útiles para el tratamiento de una infección bacteriana; también se reivindica una composición que comprende un vehículo aceptable para uso farmacéutico y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reivindicados; el uso de los compuestos o composiciones reivindicados para la elaboración de un medicamento para el tratamiento de una infección bacteriana y un procedimiento para la preparación de los compuestos reivindicados.
MX2009005978A 2006-12-06 2007-12-04 Derivados de quinolina antibacterianos. MX2009005978A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125499 2006-12-06
PCT/EP2007/063313 WO2008068267A1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (1)

Publication Number Publication Date
MX2009005978A true MX2009005978A (es) 2009-06-16

Family

ID=38126091

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005978A MX2009005978A (es) 2006-12-06 2007-12-04 Derivados de quinolina antibacterianos.

Country Status (33)

Country Link
US (1) US8415475B2 (es)
EP (1) EP2099758B1 (es)
JP (1) JP5466011B2 (es)
KR (1) KR101490222B1 (es)
CN (2) CN101553470A (es)
AP (1) AP2479A (es)
AR (1) AR064151A1 (es)
AU (1) AU2007328887B2 (es)
BR (1) BRPI0720220B8 (es)
CA (1) CA2669819C (es)
CL (1) CL2007003514A1 (es)
CY (1) CY1117766T1 (es)
DK (1) DK2099758T3 (es)
EA (1) EA016733B1 (es)
ES (1) ES2573689T3 (es)
HK (1) HK1208437A1 (es)
HR (1) HRP20160585T1 (es)
HU (1) HUE028769T2 (es)
IL (1) IL199083A (es)
JO (1) JO3271B1 (es)
ME (1) ME02498B (es)
MX (1) MX2009005978A (es)
MY (1) MY181645A (es)
NO (1) NO341983B1 (es)
NZ (1) NZ576823A (es)
PL (1) PL2099758T3 (es)
PT (1) PT2099758E (es)
RS (1) RS54794B1 (es)
SI (1) SI2099758T1 (es)
TW (1) TWI406659B (es)
UA (1) UA100972C2 (es)
WO (1) WO2008068267A1 (es)
ZA (1) ZA200903950B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104254528B (zh) 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物
JP6153604B2 (ja) 2012-04-27 2017-06-28 ヤンセン ファーマシューティカ エヌ．ベー． 抗菌性キノリン誘導体
CA2888480C (en) 2012-10-16 2021-03-16 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of ror.gamma.t
EP2909192B1 (en) 2012-10-16 2017-05-17 Janssen Pharmaceutica NV Methylene linked quinolinyl modulators of ror-gamma-t
EA201590750A1 (ru) 2012-10-16 2015-09-30 Янссен Фармацевтика Нв СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγT
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
BR112016008258A2 (pt) 2013-10-15 2017-10-10 Janssen Pharmaceutica Nv moduladores de ror?t de quinolinila
WO2016008381A1 (zh) * 2014-07-14 2016-01-21 辰欣药业股份有限公司 吡啶衍生物及其作为抗分支杆菌的应用
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
AU2016212116B2 (en) * 2015-01-27 2021-07-15 Janssen Pharmaceutica Nv Dispersible compositions
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN105601566A (zh) * 2016-02-02 2016-05-25 张敏 一种护理烧伤后感染的药物组合物
KR102480410B1 (ko) * 2016-03-07 2022-12-22 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. 항박테리아 화합물 및 그의 용도
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
WO2019145919A1 (en) * 2018-01-29 2019-08-01 Cadila Healthcare Limited Heterocyclic compounds useful as antibacterial agents
MX2023004635A (es) * 2020-10-22 2023-05-12 Lunella Biotech Inc Los inhibidores de atp mitocondrial que fijan como objetivo la subunidad gamma previenen la metastasis.
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
JP4484703B2 (ja) * 2002-07-25 2010-06-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用
ATE444068T1 (de) 2004-01-23 2009-10-15 Janssen Pharmaceutica Nv Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren
ATE392423T1 (de) 2004-01-23 2008-05-15 Janssen Pharmaceutica Nv Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien
EP1713776B1 (en) * 2004-01-29 2008-05-14 Janssen Pharmaceutica N.V. Quinoline derivatives for use as mycobacterial inhibitors
KR101371653B1 (ko) * 2004-05-28 2014-03-07 얀센 파마슈티카 엔.브이. 약물 내성 마이코박테리아 질환 치료를 위한 치환된 퀴놀린유도체의 용도
LT1797115T (lt) 2004-09-28 2017-10-10 Janssen Pharmaceutica N.V. Bakterinės atp sintazės jungimosi domenas
EE05394B1 (et) 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Also Published As

Publication number Publication date
JO3271B1 (ar) 2018-09-16
ME02498B (me) 2017-02-20
CL2007003514A1 (es) 2008-07-11
KR101490222B1 (ko) 2015-02-05
UA100972C2 (ru) 2013-02-25
EA016733B1 (ru) 2012-07-30
DK2099758T3 (en) 2016-06-13
ES2573689T3 (es) 2016-06-09
AR064151A1 (es) 2009-03-18
BRPI0720220B8 (pt) 2021-05-25
PT2099758E (pt) 2016-06-02
EP2099758A1 (en) 2009-09-16
BRPI0720220B1 (pt) 2020-06-09
NZ576823A (en) 2012-01-12
NO20092542L (no) 2009-08-25
RS54794B1 (sr) 2016-10-31
PL2099758T3 (pl) 2016-08-31
HK1208437A1 (en) 2016-03-04
AU2007328887A1 (en) 2008-06-12
JP2010511668A (ja) 2010-04-15
CN104744361B (zh) 2021-06-08
CN101553470A (zh) 2009-10-07
CN104744361A (zh) 2015-07-01
AP2009004874A0 (en) 2009-06-30
ZA200903950B (en) 2010-08-25
KR20090086604A (ko) 2009-08-13
TW200838528A (en) 2008-10-01
NO341983B1 (no) 2018-03-05
HUE028769T2 (en) 2017-01-30
BRPI0720220A2 (pt) 2013-12-24
SI2099758T1 (sl) 2016-07-29
EA200970535A1 (ru) 2009-10-30
AP2479A (en) 2012-09-27
TWI406659B (zh) 2013-09-01
US20100048566A1 (en) 2010-02-25
CY1117766T1 (el) 2017-05-17
JP5466011B2 (ja) 2014-04-09
IL199083A0 (en) 2010-03-28
EP2099758B1 (en) 2016-03-09
US8415475B2 (en) 2013-04-09
HRP20160585T1 (hr) 2016-06-17
IL199083A (en) 2014-08-31
AU2007328887B2 (en) 2013-01-17
CA2669819A1 (en) 2008-06-12
CA2669819C (en) 2016-08-30
WO2008068267A1 (en) 2008-06-12
MY181645A (en) 2020-12-30

Similar Documents

Publication Publication Date Title
UA100972C2 (ru) Антибактериальные производные хинолина
MY145924A (en) Antibacterial quinoline derivatives
HK1137431A1 (en) Antibacterial quinoline derivatives
MX355050B (es) Derivados de quinolina antibacterianos.
MY150411A (en) Antibacterial quinoline derivatives
MX2009005980A (es) Derivados antibacterianos de quinolina.
MY145940A (en) Antibacterial quinoline derivatives
MX358506B (es) Derivados de quinolina antibacterianos.
SG166799A1 (en) Quinoline derivatives as antibacterial agents
NZ700507A (en) Pyrimidine derivatives for the treatment of bacterial diseases

Legal Events

Date Code Title Description
FG Grant or registration