NO20092539L - Antibakterielle kinolin-derivater - Google Patents

Antibakterielle kinolin-derivater

Info

Publication number
NO20092539L
NO20092539L NO20092539A NO20092539A NO20092539L NO 20092539 L NO20092539 L NO 20092539L NO 20092539 A NO20092539 A NO 20092539A NO 20092539 A NO20092539 A NO 20092539A NO 20092539 L NO20092539 L NO 20092539L
Authority
NO
Norway
Prior art keywords
quinoline derivatives
formula
pharmaceutically acceptable
treatment
bacterial infection
Prior art date
Application number
NO20092539A
Other languages
English (en)
Other versions
NO341996B1 (no
Inventor
Jerome Emile Georges Guillemont
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Ismet Dorange
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20092539L publication Critical patent/NO20092539L/no
Publication of NO341996B1 publication Critical patent/NO341996B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Den foreliggende oppfinnelsen angår nye substituerte kinolinderivater ifølge den generelle formel (Ia) eller formel (Ib): inkludert enhver stereokjemisk isomerform derav, hvori Q representerer et radikal med formel , et N-oksid derav, et farmasøytisk akseptabelt salt derav eller et solvat derav. De krevde forbindelsene er nyttige i behandlingen av en bakteriell infeksjon. Også krevet er en sammensetning omfattende en farmasøytisk akseptabel bærer og, som aktiv ingrediens, en terapeutisk effektiv mengde av de krevde forbindelsene, anvendelsen av de krevde forbindelsene eller sammensetninger for fremstillingen av et medikament for behandlingen av en bakteriell infeksjon og en fremgangsmåte for å fremstille de krevde forbindelsene.
NO20092539A 2006-12-06 2009-07-06 Antibakterielle kinolin-derivater NO341996B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125546 2006-12-06
PCT/EP2007/063312 WO2008068266A1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
NO20092539L true NO20092539L (no) 2009-09-04
NO341996B1 NO341996B1 (no) 2018-03-12

Family

ID=38038656

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092539A NO341996B1 (no) 2006-12-06 2009-07-06 Antibakterielle kinolin-derivater

Country Status (34)

Country Link
US (1) US20100069366A1 (no)
EP (1) EP2099762B1 (no)
JP (1) JP5356244B2 (no)
KR (1) KR101514992B1 (no)
CN (1) CN101547907B (no)
AP (1) AP2478A (no)
AR (1) AR064153A1 (no)
AT (1) ATE467619T1 (no)
AU (1) AU2007328980B2 (no)
BR (1) BRPI0719920B8 (no)
CA (1) CA2668515C (no)
CL (1) CL2007003519A1 (no)
CY (1) CY1111188T1 (no)
DE (1) DE602007006553D1 (no)
DK (1) DK2099762T3 (no)
EA (1) EA200970534A1 (no)
ES (1) ES2345463T3 (no)
HK (1) HK1137441A1 (no)
HR (1) HRP20100428T1 (no)
IL (1) IL199079A (no)
JO (1) JO2684B1 (no)
ME (1) ME01127B (no)
MX (1) MX2009005982A (no)
MY (1) MY145924A (no)
NO (1) NO341996B1 (no)
NZ (1) NZ576863A (no)
PL (1) PL2099762T3 (no)
PT (1) PT2099762E (no)
RS (1) RS51382B (no)
SI (1) SI2099762T1 (no)
TW (1) TWI484959B (no)
UA (1) UA101305C2 (no)
WO (1) WO2008068266A1 (no)
ZA (1) ZA200903947B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5857511B2 (ja) * 2010-08-10 2016-02-10 住友化学株式会社 植物病害防除組成物およびその用途
EA038350B1 (ru) 2012-04-27 2021-08-12 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
PL2841425T3 (pl) 2012-04-27 2016-10-31 Antybakteryjne pochodne chinoliny
CN105017147B (zh) * 2014-04-30 2019-02-01 中国医学科学院药物研究所 一种回收和利用Bedaquiline立体化学异构体的方法
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
CA2954872C (en) 2014-07-14 2019-08-13 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
ES2934785T3 (es) * 2016-03-07 2023-02-27 The Global Alliance For Tb Drug Dev Inc Compuestos antibacterianos y usos de los mismos
CN109384716B (zh) * 2017-08-11 2021-06-29 海创药业股份有限公司 一种氘代喹啉化合物及其制备和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (en) * 1996-10-28 2001-04-11 Dept Of The Army Us Government COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS
RS52431B (en) 2002-07-25 2013-02-28 Janssen Pharmaceutica N.V. QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS
NZ547277A (en) 2004-01-23 2009-08-28 Janssen Pharmaceutica Nv Substituted quinolines and their use as mycobacterial inhibitors
US7902225B2 (en) * 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
JP4919810B2 (ja) * 2004-01-29 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイコバクテリア抑制剤としての使用のためのキノリン誘導体
CN102908347A (zh) * 2004-05-28 2013-02-06 詹森药业有限公司 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途
EP1677083A1 (fr) * 2004-12-22 2006-07-05 Roxer Industries S.A. Capteur de niveau d'un liquide.
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained

Also Published As

Publication number Publication date
CN101547907B (zh) 2013-01-02
AR064153A1 (es) 2009-03-18
NO341996B1 (no) 2018-03-12
EA200970534A1 (ru) 2009-10-30
TWI484959B (zh) 2015-05-21
EP2099762A1 (en) 2009-09-16
IL199079A (en) 2013-06-27
AP2478A (en) 2012-09-27
TW200840575A (en) 2008-10-16
AP2009004872A0 (en) 2009-06-30
JP2010511667A (ja) 2010-04-15
ATE467619T1 (de) 2010-05-15
CA2668515A1 (en) 2008-06-12
ES2345463T3 (es) 2010-09-23
CN101547907A (zh) 2009-09-30
KR101514992B1 (ko) 2015-04-24
US20100069366A1 (en) 2010-03-18
DK2099762T3 (da) 2010-08-30
UA101305C2 (ru) 2013-03-25
NZ576863A (en) 2011-09-30
ME01127B (me) 2013-03-20
CL2007003519A1 (es) 2008-07-11
HRP20100428T1 (hr) 2010-09-30
CA2668515C (en) 2016-03-29
BRPI0719920A2 (pt) 2014-03-04
AU2007328980B2 (en) 2013-04-18
JP5356244B2 (ja) 2013-12-04
PT2099762E (pt) 2010-08-04
HK1137441A1 (en) 2010-07-30
JO2684B1 (en) 2013-03-03
MY145924A (en) 2012-05-15
KR20090090360A (ko) 2009-08-25
WO2008068266A1 (en) 2008-06-12
MX2009005982A (es) 2009-06-16
CY1111188T1 (el) 2015-06-11
DE602007006553D1 (de) 2010-06-24
BRPI0719920B1 (pt) 2020-08-04
SI2099762T1 (sl) 2010-09-30
AU2007328980A1 (en) 2008-06-12
EP2099762B1 (en) 2010-05-12
BRPI0719920B8 (pt) 2021-05-25
PL2099762T3 (pl) 2010-10-29
ZA200903947B (en) 2010-08-25
RS51382B (en) 2011-02-28

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