PL2057185T3 - Pochodne polimyksyny i ich zastosowania - Google Patents

Pochodne polimyksyny i ich zastosowania

Info

Publication number
PL2057185T3
PL2057185T3 PL07803704.1T PL07803704T PL2057185T3 PL 2057185 T3 PL2057185 T3 PL 2057185T3 PL 07803704 T PL07803704 T PL 07803704T PL 2057185 T3 PL2057185 T3 PL 2057185T3
Authority
PL
Poland
Prior art keywords
polymyxin derivatives
polymyxin
derivatives
Prior art date
Application number
PL07803704.1T
Other languages
English (en)
Polish (pl)
Inventor
Martti Vaara
Timo Vaara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2057185T3 publication Critical patent/PL2057185T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL07803704.1T 2006-08-11 2007-08-10 Pochodne polimyksyny i ich zastosowania PL2057185T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83742606P 2006-08-11 2006-08-11
DKPA200601055 2006-08-11

Publications (1)

Publication Number Publication Date
PL2057185T3 true PL2057185T3 (pl) 2016-09-30

Family

ID=39032653

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07803704.1T PL2057185T3 (pl) 2006-08-11 2007-08-10 Pochodne polimyksyny i ich zastosowania

Country Status (21)

Country Link
EP (2) EP3078672A1 (enExample)
JP (1) JP5226685B2 (enExample)
KR (2) KR101502453B1 (enExample)
CN (2) CN101501063B (enExample)
AU (1) AU2007283514B2 (enExample)
BR (1) BRPI0715095B8 (enExample)
CA (1) CA2694289C (enExample)
CY (1) CY1117848T1 (enExample)
DK (1) DK2057185T3 (enExample)
ES (1) ES2575521T3 (enExample)
HR (1) HRP20160552T1 (enExample)
HU (1) HUE028271T2 (enExample)
IL (2) IL196693B (enExample)
MX (1) MX2009001398A (enExample)
NO (1) NO341982B1 (enExample)
NZ (1) NZ575421A (enExample)
PL (1) PL2057185T3 (enExample)
PT (1) PT2057185E (enExample)
RU (1) RU2455311C2 (enExample)
SI (1) SI2057185T1 (enExample)
WO (1) WO2008017734A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
AR074874A1 (es) 2008-12-23 2011-02-16 Biosource Pharm Inc Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto.
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
EP2780357A1 (en) * 2011-11-18 2014-09-24 Novacta Biosystems Limited Polymyxin derivatives
HUE059544T2 (hu) * 2013-05-22 2022-11-28 Spero Therapeutics Inc Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal
HRP20220387T1 (hr) * 2014-03-11 2022-05-27 Spero Therapeutics, Inc. Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima
KR101664106B1 (ko) 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
AU2015352440B2 (en) 2014-11-26 2020-02-06 Spero Therapeutics, Inc. Compounds
CA2970546A1 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
HRP20201828T1 (hr) * 2014-12-18 2021-01-08 Helperby Therapeutics Limited Nova kombinacija i uporaba
FI126143B (en) * 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
CN104672307B (zh) * 2015-03-23 2017-09-29 吉林大学 一种提高阳离子短肽抗菌性和稳定性的方法
EP3072956A1 (en) * 2015-03-25 2016-09-28 Université de Fribourg Selective culture medium for polymyxin-resistant, gram-negative bacteria
FR3036406B1 (fr) 2015-05-20 2019-07-19 Biomerieux Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire
JP2018534303A (ja) * 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators
GB201703898D0 (en) 2017-03-10 2017-04-26 Helperby Therapeautics Ltd Method
GB201704620D0 (en) 2017-03-23 2017-05-10 Helperby Therapeautics Ltd Combinations
WO2019084628A1 (en) * 2017-11-02 2019-05-09 The University Of Queensland Peptide antibiotics
EP3560489A1 (en) * 2018-04-27 2019-10-30 European Molecular Biology Laboratory Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions
EA202092819A1 (ru) 2018-06-25 2021-05-21 Сперо Терапьютикс, Инк. Соединения
EP3823454A4 (en) * 2018-07-19 2022-06-08 Northeastern University Compounds with antimicrobial properties
CN110179967A (zh) * 2019-05-28 2019-08-30 中国医药集团总公司四川抗菌素工业研究所 多粘菌素母核和一种抗生素的组合物及其应用
IT201900025414A1 (it) 2019-12-23 2021-06-23 Univ Bologna Alma Mater Studiorum Composto per il trattamento della sindrome emolitico uremica
US20230141981A1 (en) 2020-01-21 2023-05-11 Shanghai Micurx Pharmaceuticals Co., Ltd Novel compounds and composition for targeted therapy of kidney-associated cancers
CN116497039B (zh) * 2022-08-30 2024-04-09 四川大学华西医院 一类phoQ基因突变体、应用及其验证方法
WO2024123712A1 (en) * 2022-12-04 2024-06-13 Genentech, Inc. Analysis of candidate cytotoxic compositions
CN120399010B (zh) * 2025-07-01 2025-09-12 杭州肽佳生物科技有限公司 抗生素多粘菌素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450687A (en) 1966-02-24 1969-06-17 Pfizer & Co C Lower alkanoyl esters of polymyxin antibiotics
JPS4915537B1 (enExample) 1970-03-25 1974-04-16
BE754411A (fr) 1969-08-05 1971-02-04 Rhone Poulenc Sa Cyclopeptides derives des polymyxines et leur
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
US20040063754A1 (en) * 2000-11-20 2004-04-01 Hisashi Takahashi Dehalogeno compounds
US7435716B2 (en) 2001-01-16 2008-10-14 Ramot At Tel Aviv University Ltd. Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
EP1752161A3 (en) * 2002-03-01 2010-09-01 CHIESI FARMACEUTICI S.p.A. Pulmonary surfactans comprising a polymyxin for improving the surface properties
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion

Also Published As

Publication number Publication date
EP2057185A1 (en) 2009-05-13
DK2057185T3 (en) 2016-06-13
CA2694289C (en) 2015-04-07
SI2057185T1 (sl) 2016-10-28
WO2008017734A8 (en) 2009-07-30
BRPI0715095B8 (pt) 2021-05-25
CN103059106B (zh) 2015-01-14
BRPI0715095A2 (pt) 2013-10-15
MX2009001398A (es) 2009-02-17
PT2057185E (pt) 2016-06-17
KR20090045932A (ko) 2009-05-08
HRP20160552T1 (hr) 2016-07-15
NO341982B1 (no) 2018-03-05
RU2455311C2 (ru) 2012-07-10
EP3078672A1 (en) 2016-10-12
BRPI0715095B1 (pt) 2018-08-07
CA2694289A1 (en) 2008-02-14
HUE028271T2 (en) 2016-12-28
CY1117848T1 (el) 2017-05-17
JP2010500331A (ja) 2010-01-07
IL196693B (en) 2018-01-31
ES2575521T3 (es) 2016-06-29
KR20150008198A (ko) 2015-01-21
AU2007283514B2 (en) 2012-09-06
CN101501063A (zh) 2009-08-05
EP2057185B1 (en) 2016-05-11
NZ575421A (en) 2011-11-25
AU2007283514A1 (en) 2008-02-14
EP2057185A4 (en) 2009-08-19
KR101502453B1 (ko) 2015-03-24
CN103059106A (zh) 2013-04-24
IL196693A0 (en) 2009-11-18
IL220270A0 (en) 2012-07-31
NO20090674L (no) 2009-05-08
JP5226685B2 (ja) 2013-07-03
WO2008017734A1 (en) 2008-02-14
CN101501063B (zh) 2014-03-12
RU2009107857A (ru) 2010-09-20

Similar Documents

Publication Publication Date Title
IL220270A0 (en) Polymyxin derivatives and uses thereof
ZA200810323B (en) Fkbp-l and uses thereof
PL2064327T3 (pl) Dbait i ich zastosowania
ZA200807748B (en) Dihydropyrazolopyrimidinone derivatives
IL196543A0 (en) Pyridizinone derivatives
IL193641A0 (en) Spiroindolinone derivatives
IL195013A0 (en) Pyridopyrimidinone derivatives
IL198319A0 (en) Spiroindolinone derivatives
IL195422A0 (en) 2-pyrazinecarboxamide derivatives
IL192401A0 (en) Indol-3-yl-carbonyl-spiro-piperidine derivatives
IL196364A0 (en) Aminoindazolylurea derivatives
IL193211A0 (en) Indazole-heteroaryl derivatives
ZA200903906B (en) Carboranylporphyrins and uses thereof
IL198645A0 (en) 5-hydroxymethyl-oxazolidin-2-one derivatives
IL197152A0 (en) 5-phenyl-nicotinamide derivatives
EP2077262A4 (en) IMINOPYRIDINE DERIVATIVE AND USE THEREOF
GB0621160D0 (en) Compounds and uses thereof
EP2124908A4 (en) CONNECTIONS AND ITS USE
EP2120563A4 (en) CONNECTIONS AND ITS USES
IL197239A0 (en) Phenyloxyaniline derivatives
EP2099459A4 (en) COMPOUNDS AND USES THEREOF
GB0610059D0 (en) Uses and methods
EP2120957A4 (en) COMPOUNDS AND USES THEREOF
GB0625861D0 (en) Modified flexicast/flexisplint
IL196823A0 (en) Tetraarylporphine derivatives and uses thereof