AU2007283514B2 - Polymyxin derivatives and uses thereof - Google Patents

Polymyxin derivatives and uses thereof Download PDF

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Publication number
AU2007283514B2
AU2007283514B2 AU2007283514A AU2007283514A AU2007283514B2 AU 2007283514 B2 AU2007283514 B2 AU 2007283514B2 AU 2007283514 A AU2007283514 A AU 2007283514A AU 2007283514 A AU2007283514 A AU 2007283514A AU 2007283514 B2 AU2007283514 B2 AU 2007283514B2
Authority
AU
Australia
Prior art keywords
dab
polymyxin
derivative
seq
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007283514A
Other languages
English (en)
Other versions
AU2007283514A1 (en
Inventor
Martti Vaara
Timo Vaara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northern Antibiotics Oy
Original Assignee
Northern Antibiotics Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northern Antibiotics Oy filed Critical Northern Antibiotics Oy
Publication of AU2007283514A1 publication Critical patent/AU2007283514A1/en
Application granted granted Critical
Publication of AU2007283514B2 publication Critical patent/AU2007283514B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2007283514A 2006-08-11 2007-08-10 Polymyxin derivatives and uses thereof Ceased AU2007283514B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83742606P 2006-08-11 2006-08-11
DKPA200601055 2006-08-11
US60/837,426 2006-08-11
DKPA200601055 2006-08-11
PCT/FI2007/050441 WO2008017734A1 (en) 2006-08-11 2007-08-10 Polymyxin derivatives and uses thereof

Publications (2)

Publication Number Publication Date
AU2007283514A1 AU2007283514A1 (en) 2008-02-14
AU2007283514B2 true AU2007283514B2 (en) 2012-09-06

Family

ID=39032653

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007283514A Ceased AU2007283514B2 (en) 2006-08-11 2007-08-10 Polymyxin derivatives and uses thereof

Country Status (21)

Country Link
EP (2) EP2057185B1 (enExample)
JP (1) JP5226685B2 (enExample)
KR (2) KR20150008198A (enExample)
CN (2) CN101501063B (enExample)
AU (1) AU2007283514B2 (enExample)
BR (1) BRPI0715095B8 (enExample)
CA (1) CA2694289C (enExample)
CY (1) CY1117848T1 (enExample)
DK (1) DK2057185T3 (enExample)
ES (1) ES2575521T3 (enExample)
HR (1) HRP20160552T1 (enExample)
HU (1) HUE028271T2 (enExample)
IL (2) IL196693B (enExample)
MX (1) MX2009001398A (enExample)
NO (1) NO341982B1 (enExample)
NZ (1) NZ575421A (enExample)
PL (1) PL2057185T3 (enExample)
PT (1) PT2057185E (enExample)
RU (1) RU2455311C2 (enExample)
SI (1) SI2057185T1 (enExample)
WO (1) WO2008017734A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8343912B2 (en) 2008-12-23 2013-01-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
EP2780357A1 (en) 2011-11-18 2014-09-24 Novacta Biosystems Limited Polymyxin derivatives
EP2999711B1 (en) * 2013-05-22 2022-06-29 Spero Therapeutics, Inc. Polymyxin derivatives and their use in combination therapy together with different antibiotics
KR20160135739A (ko) * 2014-03-11 2016-11-28 뉴 파마 라이센스 홀딩스 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
KR101664106B1 (ko) 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
WO2016083531A1 (en) 2014-11-26 2016-06-02 New Pharma Licence Holdings Limited Compounds
JP6896628B2 (ja) 2014-12-16 2021-06-30 シャンハイ ミクウルク ファーマシューティカル シーオー．エルティーディー 細菌感染症の治療のための抗微生物性ポリミキシン
JP6629327B2 (ja) * 2014-12-18 2020-01-15 ヘルパービー セラピューティクス リミテッドＨｅｌｐｅｒｂｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 微生物感染の予防または治療で使用される組み合わせ
FI126143B (en) * 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
CN104672307B (zh) * 2015-03-23 2017-09-29 吉林大学 一种提高阳离子短肽抗菌性和稳定性的方法
EP3072956A1 (en) * 2015-03-25 2016-09-28 Université de Fribourg Selective culture medium for polymyxin-resistant, gram-negative bacteria
FR3036406B1 (fr) 2015-05-20 2019-07-19 Biomerieux Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire
EP3374027B1 (en) * 2015-11-12 2021-06-23 The Trustees of Columbia University in the City of New York Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators
WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
GB201703898D0 (en) 2017-03-10 2017-04-26 Helperby Therapeautics Ltd Method
GB201704620D0 (en) 2017-03-23 2017-05-10 Helperby Therapeautics Ltd Combinations
AU2018359018B2 (en) * 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
EP3560489A1 (en) * 2018-04-27 2019-10-30 European Molecular Biology Laboratory Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions
KR20210054500A (ko) 2018-06-25 2021-05-13 스페로 테라퓨틱스, 인코퍼레이티드 화합물
CN112739710B (zh) * 2018-07-19 2024-08-27 东北大学 具有抗菌特性的化合物
CN110179967A (zh) * 2019-05-28 2019-08-30 中国医药集团总公司四川抗菌素工业研究所 多粘菌素母核和一种抗生素的组合物及其应用
IT201900025414A1 (it) * 2019-12-23 2021-06-23 Univ Bologna Alma Mater Studiorum Composto per il trattamento della sindrome emolitico uremica
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物
CN118028501B (zh) * 2022-08-30 2024-08-02 四川大学华西医院 一类phoQ基因突变体、应用及其验证方法
WO2024123712A1 (en) * 2022-12-04 2024-06-13 Genentech, Inc. Analysis of candidate cytotoxic compositions
CN120399010B (zh) * 2025-07-01 2025-09-12 杭州肽佳生物科技有限公司 抗生素多粘菌素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450687A (en) 1966-02-24 1969-06-17 Pfizer & Co C Lower alkanoyl esters of polymyxin antibiotics
JPS4915537B1 (enExample) 1970-03-25 1974-04-16
BE754411A (fr) 1969-08-05 1971-02-04 Rhone Poulenc Sa Cyclopeptides derives des polymyxines et leur
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
IL155976A0 (en) * 2000-11-20 2003-12-23 Daiichi Seiyaku Co Dehalogeno compounds
CA2444637A1 (en) 2001-01-16 2002-07-18 Ramot University Authority For Applied Research & Industrial Development Ltd. Hybrid peptides for treatment of bacteremia and septicemia
DE60217060T2 (de) * 2002-03-01 2007-06-21 Chiesi Farmaceutici S.P.A. Pharmazeutische Zusammensetzungen, die Lungensurfactants und ein Polymyxin umfassen und verbesserte Oberflächenspannung-senkende Eigenschaften haben
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Thomas et al. (1999) FEBS Letters 445: 420-424 *
Tsubery et al. (2001) Peptides 22: 1675-1681 *

Also Published As

Publication number Publication date
IL196693A0 (en) 2009-11-18
EP2057185A1 (en) 2009-05-13
HUE028271T2 (en) 2016-12-28
CY1117848T1 (el) 2017-05-17
IL196693B (en) 2018-01-31
EP2057185A4 (en) 2009-08-19
EP2057185B1 (en) 2016-05-11
BRPI0715095B8 (pt) 2021-05-25
KR20150008198A (ko) 2015-01-21
CN103059106B (zh) 2015-01-14
BRPI0715095A2 (pt) 2013-10-15
SI2057185T1 (sl) 2016-10-28
CN101501063B (zh) 2014-03-12
CA2694289C (en) 2015-04-07
JP5226685B2 (ja) 2013-07-03
HRP20160552T1 (hr) 2016-07-15
EP3078672A1 (en) 2016-10-12
PT2057185E (pt) 2016-06-17
WO2008017734A8 (en) 2009-07-30
MX2009001398A (es) 2009-02-17
WO2008017734A1 (en) 2008-02-14
ES2575521T3 (es) 2016-06-29
CN103059106A (zh) 2013-04-24
BRPI0715095B1 (pt) 2018-08-07
NO341982B1 (no) 2018-03-05
AU2007283514A1 (en) 2008-02-14
KR20090045932A (ko) 2009-05-08
RU2455311C2 (ru) 2012-07-10
CN101501063A (zh) 2009-08-05
NO20090674L (no) 2009-05-08
CA2694289A1 (en) 2008-02-14
PL2057185T3 (pl) 2016-09-30
IL220270A0 (en) 2012-07-31
DK2057185T3 (en) 2016-06-13
JP2010500331A (ja) 2010-01-07
NZ575421A (en) 2011-11-25
RU2009107857A (ru) 2010-09-20
KR101502453B1 (ko) 2015-03-24

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired