CY1115717T1 - Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης - Google Patents

Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης

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Publication number
CY1115717T1
CY1115717T1 CY20141100911T CY141100911T CY1115717T1 CY 1115717 T1 CY1115717 T1 CY 1115717T1 CY 20141100911 T CY20141100911 T CY 20141100911T CY 141100911 T CY141100911 T CY 141100911T CY 1115717 T1 CY1115717 T1 CY 1115717T1
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CY
Cyprus
Prior art keywords
signal
describes
diseases
sequence
denylife
Prior art date
Application number
CY20141100911T
Other languages
Greek (el)
English (en)
Inventor
Andreas Thess
Thomas Schlake
Jochen Probst
Original Assignee
Curevac Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Gmbh filed Critical Curevac Gmbh
Publication of CY1115717T1 publication Critical patent/CY1115717T1/el

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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CY20141100911T 2010-08-13 2014-11-04 Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης CY1115717T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2010/004998 WO2012019630A1 (en) 2010-08-13 2010-08-13 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
EP11745701.0A EP2603590B1 (en) 2010-08-13 2011-08-12 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein

Publications (1)

Publication Number Publication Date
CY1115717T1 true CY1115717T1 (el) 2017-01-25

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CY20141100911T CY1115717T1 (el) 2010-08-13 2014-11-04 Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης

Country Status (20)

Country Link
US (5) US9234013B2 (cg-RX-API-DMAC7.html)
EP (2) EP2796557A1 (cg-RX-API-DMAC7.html)
JP (2) JP5860464B2 (cg-RX-API-DMAC7.html)
KR (1) KR101720063B1 (cg-RX-API-DMAC7.html)
CN (1) CN103068987B (cg-RX-API-DMAC7.html)
AU (1) AU2011289021B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013003378A2 (cg-RX-API-DMAC7.html)
CA (1) CA2801218C (cg-RX-API-DMAC7.html)
CY (1) CY1115717T1 (cg-RX-API-DMAC7.html)
DK (1) DK2603590T3 (cg-RX-API-DMAC7.html)
ES (1) ES2525556T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20140949T1 (cg-RX-API-DMAC7.html)
MX (1) MX342933B (cg-RX-API-DMAC7.html)
PL (1) PL2603590T3 (cg-RX-API-DMAC7.html)
PT (1) PT2603590E (cg-RX-API-DMAC7.html)
RS (1) RS53593B1 (cg-RX-API-DMAC7.html)
RU (1) RU2583295C2 (cg-RX-API-DMAC7.html)
SG (1) SG186702A1 (cg-RX-API-DMAC7.html)
SI (1) SI2603590T1 (cg-RX-API-DMAC7.html)
WO (2) WO2012019630A1 (cg-RX-API-DMAC7.html)

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CN103068987B (zh) 2015-05-13
RU2013110779A (ru) 2014-09-20
US10653799B2 (en) 2020-05-19
JP2013535969A (ja) 2013-09-19
US20180055952A1 (en) 2018-03-01

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