CY1115717T1 - Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης - Google Patents
Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνηςInfo
- Publication number
- CY1115717T1 CY1115717T1 CY20141100911T CY141100911T CY1115717T1 CY 1115717 T1 CY1115717 T1 CY 1115717T1 CY 20141100911 T CY20141100911 T CY 20141100911T CY 141100911 T CY141100911 T CY 141100911T CY 1115717 T1 CY1115717 T1 CY 1115717T1
- Authority
- CY
- Cyprus
- Prior art keywords
- signal
- describes
- diseases
- sequence
- denylife
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 108010033040 Histones Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108091034057 RNA (poly(A)) Proteins 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108020004705 Codon Proteins 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008488 polyadenylation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract
Η παρούσα αίτηση περιγράφει μια αλληλουχία νουκλεϊνικού οξέος κωδικοποίησης, και ιδιαίτερα ένα αγγελιαφόρο RNA (mRNA), που περιέχει ή κωδικοποιεί έναν βλαστό-βρόχο ιστόνης και μια πολυ(Α)αλληλουχία ή ένα σήμα πολυαδενυλίωσης και τη χρήση αυτής για αύξηση της έκφρασης μιας κωδικοποιούμενης πρωτεΐνης. Επίσης περιγράφει τη χρήση της για την παρασκευή μιας φαρμακευτικής σύνθεσης, και ιδιαίτερα ενός εμβολίου π.χ. για τη χρήση στη θεραπεία όγκων και καρκινικών νόσων, καρδιαγγειακών νόσεων, μολυσματικών νόσων, αυτοάνοσων νόσων, γενετικών νόσων, ή στη γονιδιακή θεραπεία. Η παρούσα εφεύρεση επίσης περιγράφει μια in vitro μέθοδο μεταγραφής, in vitro μεθόδους για αύξηση της έκφρασης μιας πρωτεΐνης με χρήση του νουκλεϊνικού οξέος που περιέχει ή κωδικοποιεί έναν βλαστό-βρόχο ιστόνης και μια πολυ(Α)αλληλουχία ή ένα σήμα πολυαδευλίωσης και μια ex vivo και in vivo μέθοδο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/004998 WO2012019630A1 (en) | 2010-08-13 | 2010-08-13 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
EP11745701.0A EP2603590B1 (en) | 2010-08-13 | 2011-08-12 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
Publications (1)
Publication Number | Publication Date |
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CY1115717T1 true CY1115717T1 (el) | 2017-01-25 |
Family
ID=43086880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100911T CY1115717T1 (el) | 2010-08-13 | 2014-11-04 | Νουκλεϊνικο οξυ που περιεχει ή κωδικοποιει εναν βλαστο-βροχο ιστονης και μια πολυ(α)αλληλουχια ή ενα σημα πολυαδενυλιωσης για αυξηση της εκφρασης μιας κωδικοποιουμενης πρωτεϊνης |
Country Status (20)
Country | Link |
---|---|
US (4) | US9234013B2 (el) |
EP (2) | EP2796557A1 (el) |
JP (2) | JP5860464B2 (el) |
KR (1) | KR101720063B1 (el) |
CN (1) | CN103068987B (el) |
AU (1) | AU2011289021B2 (el) |
BR (1) | BR112013003378A2 (el) |
CA (1) | CA2801218C (el) |
CY (1) | CY1115717T1 (el) |
DK (1) | DK2603590T3 (el) |
ES (1) | ES2525556T3 (el) |
HR (1) | HRP20140949T1 (el) |
MX (1) | MX342933B (el) |
PL (1) | PL2603590T3 (el) |
PT (1) | PT2603590E (el) |
RS (1) | RS53593B1 (el) |
RU (1) | RU2583295C2 (el) |
SG (1) | SG186702A1 (el) |
SI (1) | SI2603590T1 (el) |
WO (2) | WO2012019630A1 (el) |
Families Citing this family (217)
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WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
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EP2814964B1 (en) * | 2012-02-15 | 2019-01-09 | CureVac AG | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
EP3348644B1 (en) * | 2012-02-15 | 2020-02-12 | CureVac AG | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
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PL2814962T3 (pl) * | 2012-02-15 | 2018-11-30 | Curevac Ag | Kwas nukleinowy zawierający lub kodujący histonowy trzonek-pętlę i sekwencję poli(A) lub sygnał poliadenylacji do zwiększania ekspresji zakodowanego antygenu patogennego |
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KR20140139101A (ko) | 2012-03-27 | 2014-12-04 | 큐어백 게엠바하 | 5''top utr을 포함하는 인공 핵산 분자 |
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DK2831241T3 (da) | 2012-03-27 | 2017-11-06 | Curevac Ag | Kunstige nukleinsyremolekyler til forbedret protein- eller peptidekspression. |
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EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
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