CY1121805T1 - Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκου - Google Patents

Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκου

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Publication number
CY1121805T1
CY1121805T1 CY20191100744T CY191100744T CY1121805T1 CY 1121805 T1 CY1121805 T1 CY 1121805T1 CY 20191100744 T CY20191100744 T CY 20191100744T CY 191100744 T CY191100744 T CY 191100744T CY 1121805 T1 CY1121805 T1 CY 1121805T1
Authority
CY
Cyprus
Prior art keywords
nucleic acid
encoding
sequence
poly
loop
Prior art date
Application number
CY20191100744T
Other languages
English (en)
Inventor
Andreas Thess
Thomas Schlake
Jochen Probst
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/000674 external-priority patent/WO2013120500A1/en
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of CY1121805T1 publication Critical patent/CY1121805T1/el

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Abstract

Η παρούσα εφεύρεση αφορά σε μία αλληλουχία νουκλεϊνικού οξέος που περιλαμβάνει ή κωδικοποιεί κωδικοποιητική περιοχή που κωδικοποιεί τουλάχιστον ένα πεπτίδιο ή πρωτεΐνη που περιλαμβάνει αντιγόνο όγκου ή θραύσμα, παραλλαγή ή παράγωγο αυτού, τουλάχιστον ένα στέλεχος-βρόχο ιστόνης και πολυ(Α) αλληλουχία ή σήμα πολυαδενυλίωσης. Περαιτέρω, η παρούσα εφεύρεση παρέχει τη χρήση του νουκλεϊνικού οξέος για αύξηση της έκφρασης του εν λόγω κωδικοποιημένου πεπτιδίου ή πρωτεΐνης. Επίσης αποκαλύπτει χρήση αυτού για την παρασκευή μιας φαρμακευτικής σύνθεσης, ειδικώς ενός εμβολίου, π.χ. για χρήση στη θεραπεία καρκίνου ή ασθενειών όγκου. Η παρούσα εφεύρεση περαιτέρω περιγράφει μέθοδο για αύξηση της έκφρασης ενός πεπτιδίου ή πρωτεΐνης που περιλαμβάνει αντιγόνο όγκου ή θραύσμα, παραλλαγή ή παράγωγο αυτού, χρησιμοποιώντας το νουκλεϊνικό οξύ που περιλαμβάνει ή κωδικοποιεί στέλεχος-βρόχο ιστόνης και πολυ(Α) αλληλουχία ή σήμα πολυαδενυλίωσης.
CY20191100744T 2012-02-15 2019-07-11 Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκου CY1121805T1 (el)

Applications Claiming Priority (3)

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PCT/EP2012/000674 WO2013120500A1 (en) 2012-02-15 2012-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
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