MX361728B - Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado. - Google Patents

Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado.

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Publication number
MX361728B
MX361728B MX2014009909A MX2014009909A MX361728B MX 361728 B MX361728 B MX 361728B MX 2014009909 A MX2014009909 A MX 2014009909A MX 2014009909 A MX2014009909 A MX 2014009909A MX 361728 B MX361728 B MX 361728B
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MX
Mexico
Prior art keywords
nucleic acid
sequence
coding
poly
expression
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MX2014009909A
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English (en)
Other versions
MX2014009909A (es
Inventor
Probst Jochen
Schlake Thomas
Thess Andreas
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Curevac Ag
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Publication date
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Publication of MX2014009909A publication Critical patent/MX2014009909A/es
Publication of MX361728B publication Critical patent/MX361728B/es

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    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Abstract

La presente invención se refiere a una secuencia de ácidos nucleicos, que comprende o codifica una región de codificación, que codifica por lo menos un péptido o proteína que comprende un antígeno tumoral o un fragmento, variante o derivado del mismo, por lo menos un tallo-bucle de histona y una secuencia de poli(A) o una señal de poliadenilación. Adicionalmente, la presente invención proporciona el uso del ácido nucleico para incrementar la expresión del péptido o proteína codificada. También se describe su uso para la preparación de una composición farmacéutica, especialmente una vacuna, por ejemplo para el uso en el tratamiento de enfermedades cancerosas o tumorales. La presente invención describe además un método para incrementar la expresión de un péptido o proteína que comprende un antígeno tumoral o un fragmento, variante o derivado del mismo, utilizando el ácido nucleico que comprende o que codifica un tallo-bucle de histona y una secuencia poli(A) o una señal de poliadenilación.
MX2014009909A 2012-02-15 2013-02-15 Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado. MX361728B (es)

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PCT/EP2012/000674 WO2013120500A1 (en) 2012-02-15 2012-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
PCT/EP2013/000459 WO2013120627A1 (en) 2012-02-15 2013-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen

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