WO2011003935A9 - Parathyroid hormone related protein antagonists - Google Patents

Parathyroid hormone related protein antagonists Download PDF

Info

Publication number
WO2011003935A9
WO2011003935A9 PCT/EP2010/059713 EP2010059713W WO2011003935A9 WO 2011003935 A9 WO2011003935 A9 WO 2011003935A9 EP 2010059713 W EP2010059713 W EP 2010059713W WO 2011003935 A9 WO2011003935 A9 WO 2011003935A9
Authority
WO
WIPO (PCT)
Prior art keywords
related protein
alphabodies
parathyroid hormone
hormone related
protein antagonists
Prior art date
Application number
PCT/EP2010/059713
Other languages
French (fr)
Other versions
WO2011003935A4 (en
WO2011003935A1 (en
Inventor
Stefan Loverix
Johan Desmet
Ignace Lasters
Sophie Vanwetswinkel
Patrick Van Gelder
Original Assignee
Complix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix Nv filed Critical Complix Nv
Publication of WO2011003935A1 publication Critical patent/WO2011003935A1/en
Publication of WO2011003935A4 publication Critical patent/WO2011003935A4/en
Publication of WO2011003935A9 publication Critical patent/WO2011003935A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
PCT/EP2010/059713 2009-07-08 2010-07-07 Parathyroid hormone related protein antagonists WO2011003935A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0911892A GB2471693A (en) 2009-07-08 2009-07-08 Parathyroid hormone related protein antagonists
GB0911892.8 2009-07-08

Publications (3)

Publication Number Publication Date
WO2011003935A1 WO2011003935A1 (en) 2011-01-13
WO2011003935A4 WO2011003935A4 (en) 2011-04-07
WO2011003935A9 true WO2011003935A9 (en) 2011-06-03

Family

ID=41022368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/059713 WO2011003935A1 (en) 2009-07-08 2010-07-07 Parathyroid hormone related protein antagonists

Country Status (2)

Country Link
GB (1) GB2471693A (en)
WO (1) WO2011003935A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504064A (en) * 2012-01-06 2015-02-05 コンプリクス エン ヴェー Binding agents for intracellular target molecules
AU2013336753B2 (en) 2012-10-22 2018-02-01 Complix Nv Polypeptides capable of cellular internalization
CN105431548A (en) 2013-03-15 2016-03-23 生物医学研究机构基金会 Method for the diagnosis, prognosis and treatment of cancer metastasis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990035755A (en) * 1995-07-20 1999-05-25 와트 씨 데이빗, 해리 에이 루스제 Compounds related to parathyroid hormone-like proteins and methods for their preparation
ATE420661T1 (en) * 2000-04-28 2009-01-15 Chugai Pharmaceutical Co Ltd CELL PROLIFERATION INHIBITORS
WO2005077103A2 (en) * 2004-02-12 2005-08-25 Regents Of The University Of Colorado Compositions and methods for modification and prevention of sars coronavirus infectivity
US9217011B2 (en) * 2007-09-07 2015-12-22 Complix Nv Non-natural proteinaceous scaffold made of three non-covalently associated peptides

Also Published As

Publication number Publication date
WO2011003935A4 (en) 2011-04-07
GB2471693A (en) 2011-01-12
WO2011003935A1 (en) 2011-01-13
GB0911892D0 (en) 2009-08-19

Similar Documents

Publication Publication Date Title
PH12019500644A1 (en) Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
WO2011143624A3 (en) Humanized and chimeric monoclonal antibodies to cd47
WO2008142164A3 (en) Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders
CA2818990C (en) Designed repeat proteins binding to serum albumin
WO2011003557A8 (en) A complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
PH12015501092A1 (en) Anti-ceacam5 antibodies and uses thereof
MX359953B (en) Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein.
WO2011020783A3 (en) Targeted immunoconjugates
NZ705370A (en) Fcγriib-specific fc region variant
UA100682C2 (en) Antibody which neutralizes human cytomegalovirus (hcmv) and use thereof
WO2010115998A3 (en) Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
UA97516C2 (en) Fully human anti-vap-1 monoclonal antibody
MX2011013903A (en) Chimeric fgf19 polypeptides and uses thereof.
MY177065A (en) 4-1bb binding molecules
WO2011038933A3 (en) Anti-hsv antibody
WO2007104529A3 (en) Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
WO2013040093A3 (en) Glucagon-like peptide-2 compositions and methods of making and using same
WO2010010551A3 (en) Angiopoietin derived peptides
UA113623C2 (en) TISSUE FACTOR FACTOR (TFPI) MONOCLONAL ANTIBODY AGAINST TISSUE FACTOR INHIBITOR
WO2012083302A3 (en) Compositions and methods for the treatment or prevention of human adenovirus-36 infection
UA96279C2 (en) Isolated antibody or fragment thereof that is capable of binding to human nogo
MY150226A (en) Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and medicinal use
UA105073C2 (en) Anti-fractalkine antibody, composition and method for treating inflammatory disorders
IN2014DN06920A (en)
WO2009138494A3 (en) Amino acid sequences directed against toll-like receptors and their use for the treatment of diseases related to toll-like receptors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10737001

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10737001

Country of ref document: EP

Kind code of ref document: A1