UA96279C2 - Изолированное антитело или его фрагмент, способное к связыванию с человеческим nogo - Google Patents

Изолированное антитело или его фрагмент, способное к связыванию с человеческим nogo

Info

Publication number
UA96279C2
UA96279C2 UAA200807663A UAA200807663A UA96279C2 UA 96279 C2 UA96279 C2 UA 96279C2 UA A200807663 A UAA200807663 A UA A200807663A UA A200807663 A UAA200807663 A UA A200807663A UA 96279 C2 UA96279 C2 UA 96279C2
Authority
UA
Ukraine
Prior art keywords
antibody
fragment
binding
isolated antibody
human nogo
Prior art date
Application number
UAA200807663A
Other languages
English (en)
Ukrainian (uk)
Inventor
Стефанія Джейн Кліґґ
Джонатан Генрі Елліс
Волкер Ґермащевскі
Пол Ендрю Амблі
Ґеорґ Коспідас
Рус Макадам
Рабіндер Кумар Прінйоха
Original Assignee
Ґлаксо Ґруп Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35736284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96279(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ґлаксо Ґруп Лімітед filed Critical Ґлаксо Ґруп Лімітед
Publication of UA96279C2 publication Critical patent/UA96279C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Abstract

Изобретение относится к изолированному антителу или его фрагменту, способному к связыванию с человеческим NOGO, нуклеиновой кислоты, которая его кодирует, вектора, клетки-хозяина, способа получения данного антитела. Изобретение также относится к фармацевтической композиции, которая содержит антитело, и применение данного антитела для приготовления лекарственного средства для лечения или профилактики инсульта и других неврологических заболеваний.
UAA200807663A 2005-12-16 2006-12-14 Изолированное антитело или его фрагмент, способное к связыванию с человеческим nogo UA96279C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0525662.3A GB0525662D0 (en) 2005-12-16 2005-12-16 Immunoglobulins

Publications (1)

Publication Number Publication Date
UA96279C2 true UA96279C2 (ru) 2011-10-25

Family

ID=35736284

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200807663A UA96279C2 (ru) 2005-12-16 2006-12-14 Изолированное антитело или его фрагмент, способное к связыванию с человеческим nogo

Country Status (31)

Country Link
US (2) US8362208B2 (ru)
EP (2) EP2228391A3 (ru)
JP (1) JP5015949B2 (ru)
KR (1) KR101355118B1 (ru)
CN (1) CN101374863B (ru)
AR (1) AR057239A1 (ru)
AU (1) AU2006325228B2 (ru)
BR (1) BRPI0619855A2 (ru)
CA (1) CA2633501C (ru)
CR (1) CR10099A (ru)
CY (1) CY1113094T1 (ru)
DK (1) DK1960429T3 (ru)
EA (1) EA015536B1 (ru)
ES (1) ES2389380T3 (ru)
GB (1) GB0525662D0 (ru)
HK (1) HK1119720A1 (ru)
HR (1) HRP20120684T1 (ru)
IL (1) IL192086A0 (ru)
JO (1) JO2795B1 (ru)
MA (1) MA30041B1 (ru)
MY (1) MY149492A (ru)
NO (1) NO20082699L (ru)
NZ (1) NZ569143A (ru)
PE (1) PE20071099A1 (ru)
PL (1) PL1960429T3 (ru)
PT (1) PT1960429E (ru)
SI (1) SI1960429T1 (ru)
TW (1) TWI378940B (ru)
UA (1) UA96279C2 (ru)
WO (1) WO2007068750A2 (ru)
ZA (2) ZA200805111B (ru)

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ES2654937T3 (es) 2008-04-02 2018-02-15 Macrogenics, Inc. Anticuerpos específicos para el complejo BCR y procedimientos de uso de los mismos
TW201012490A (en) 2008-05-06 2010-04-01 Glaxo Group Ltd Encapsulation of biologically active agents
JP2011527317A (ja) * 2008-07-11 2011-10-27 グラクソ グループ リミテッド Ｎｏｇｏ−ａアンタゴニストによる筋萎縮性側索硬化症の治療
US8828390B2 (en) 2010-07-09 2014-09-09 Universitat Zurich Uses of NOGO-A inhibitors and related methods
AU2013285493A1 (en) 2012-07-05 2015-01-22 Glaxo Group Limited Optimum dose regime of an anti-Nogo-A antibody in the treatment of amyotrophic lateral sclerosis
US20180362660A1 (en) * 2016-05-09 2018-12-20 Schickwann Tsai Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes
US11013815B2 (en) 2017-06-14 2021-05-25 Monojul, Llc High-affinity anti-human folate receptor beta antibodies and methods of use
US20230399390A1 (en) 2019-10-24 2023-12-14 Novago Therapeutics Ag Novel anti-nogo-a antibodies
GB202012331D0 (en) 2020-08-07 2020-09-23 Petmedix Ltd Therapeutic antibodies
WO2022263864A1 (en) 2021-06-17 2022-12-22 Petmedix Ltd Anti canine cd20 antibodies
WO2023067358A1 (en) 2021-10-21 2023-04-27 Petmedix Ltd Proteins comprising the extracellular domain of p75ntr
CN116251181B (zh) * 2021-12-02 2023-09-22 北京东方百泰生物科技股份有限公司 一种抗tslp单克隆抗体的注射制剂
WO2023152486A1 (en) 2022-02-09 2023-08-17 Petmedix Ltd Therapeutic antibodies
WO2024041450A1 (zh) * 2022-08-22 2024-02-29 舒泰神（北京）生物制药股份有限公司 特异性识别Nogo-A的抗体及其应用

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Also Published As

Publication number Publication date
WO2007068750A2 (en) 2007-06-21
KR101355118B1 (ko) 2014-02-06
EP1960429B1 (en) 2012-06-27
HK1119720A1 (en) 2009-03-13
ZA200805111B (en) 2009-12-30
GB0525662D0 (en) 2006-01-25
US20130287781A1 (en) 2013-10-31
US20100221260A1 (en) 2010-09-02
AU2006325228B2 (en) 2011-12-15
KR20080080644A (ko) 2008-09-04
ES2389380T3 (es) 2012-10-25
CA2633501C (en) 2015-03-31
PT1960429E (pt) 2012-09-25
NZ569143A (en) 2011-08-26
ZA200906162B (en) 2010-05-26
TW200801038A (en) 2008-01-01
CN101374863B (zh) 2013-05-29
WO2007068750A3 (en) 2007-11-29
JP5015949B2 (ja) 2012-09-05
PL1960429T3 (pl) 2012-11-30
CY1113094T1 (el) 2016-04-13
BRPI0619855A2 (pt) 2011-10-25
AR057239A1 (es) 2007-11-21
NO20082699L (no) 2008-09-08
IL192086A0 (en) 2008-12-29
DK1960429T3 (da) 2012-09-24
CR10099A (es) 2008-09-22
EP2228391A2 (en) 2010-09-15
JO2795B1 (en) 2014-03-15
MY149492A (en) 2013-09-13
PE20071099A1 (es) 2007-11-22
EP1960429A2 (en) 2008-08-27
CA2633501A1 (en) 2007-06-21
TWI378940B (en) 2012-12-11
US8362208B2 (en) 2013-01-29
CN101374863A (zh) 2009-02-25
MA30041B1 (fr) 2008-12-01
EP2228391A3 (en) 2010-12-29
EA015536B1 (ru) 2011-08-30
SI1960429T1 (sl) 2012-09-28
HRP20120684T1 (hr) 2012-09-30
JP2009519025A (ja) 2009-05-14
AU2006325228A1 (en) 2007-06-21
EA200801343A1 (ru) 2008-12-30

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