JP5860464B2 - コードされたタンパク質の発現を増加させるための、ヒストンステムループおよびポリ（ａ）配列またはポリアデニル化シグナルを含むかまたはコードする核酸 - Google Patents

コードされたタンパク質の発現を増加させるための、ヒストンステムループおよびポリ（ａ）配列またはポリアデニル化シグナルを含むかまたはコードする核酸 Download PDF

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JP5860464B2
JP5860464B2 JP2013523537A JP2013523537A JP5860464B2 JP 5860464 B2 JP5860464 B2 JP 5860464B2 JP 2013523537 A JP2013523537 A JP 2013523537A JP 2013523537 A JP2013523537 A JP 2013523537A JP 5860464 B2 JP5860464 B2 JP 5860464B2
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histone
stem
poly
nucleic acid
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アンドレアス テス，
アンドレアス テス，
トーマス シュラーケ，
トーマス シュラーケ，
ヨッヒェン プロープスト，
ヨッヒェン プロープスト，
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キュアヴァック ゲーエムベーハー
キュアヴァック ゲーエムベーハー
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JP2013523537A 2010-08-13 2011-08-12 コードされたタンパク質の発現を増加させるための、ヒストンステムループおよびポリ（ａ）配列またはポリアデニル化シグナルを含むかまたはコードする核酸 Active JP5860464B2 (ja)

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Application Number Priority Date Filing Date Title
PCT/EP2010/004998 WO2012019630A1 (en) 2010-08-13 2010-08-13 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
EPPCT/EP2010/004998 2010-08-13
PCT/EP2011/004077 WO2012019780A1 (en) 2010-08-13 2011-08-12 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein

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JP2015247498A Division JP2016041080A (ja) 2010-08-13 2015-12-18 コードされたタンパク質の発現を増加させるための、ヒストンステムループおよびポリ（ａ）配列またはポリアデニル化シグナルを含むかまたはコードする核酸

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JP2013535969A JP2013535969A (ja) 2013-09-19
JP2013535969A5 JP2013535969A5 (cg-RX-API-DMAC7.html) 2014-04-17
JP5860464B2 true JP5860464B2 (ja) 2016-02-16

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JP2015247498A Withdrawn JP2016041080A (ja) 2010-08-13 2015-12-18 コードされたタンパク質の発現を増加させるための、ヒストンステムループおよびポリ（ａ）配列またはポリアデニル化シグナルを含むかまたはコードする核酸

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Cited By (3)

* Cited by examiner, † Cited by third party
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JP2015508646A (ja) * 2012-02-15 2015-03-23 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている治療用タンパク質の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸
JP2015508645A (ja) * 2012-02-15 2015-03-23 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている腫瘍抗原の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸
JP2015509363A (ja) * 2012-02-15 2015-03-30 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている病原体抗原の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸

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WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
WO2012075040A2 (en) 2010-11-30 2012-06-07 Shire Human Genetic Therapies, Inc. mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
WO2012089225A1 (en) 2010-12-29 2012-07-05 Curevac Gmbh Combination of vaccination and inhibition of mhc class i restricted antigen presentation
WO2012116715A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in newborns and infants
WO2012113413A1 (en) 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
WO2012116714A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
LT2717893T (lt) 2011-06-08 2019-08-12 Translate Bio, Inc. Lipidų nanodalelių kompozicijos ir mrnr pristatymo būdai
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
DE21212055T1 (de) 2011-12-07 2022-08-04 Alnylam Pharmaceuticals, Inc. Biologisch abbaubare lipide zur freisetzung von wirkstoffen
SMT202200355T1 (it) 2011-12-16 2022-11-18 Modernatx Inc Composizioni di mrna modificato
EP2814962B1 (en) * 2012-02-15 2018-07-04 CureVac AG Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
PL3178488T3 (pl) * 2012-02-15 2019-10-31 Curevac Ag Kwas nukleinowy zawierający lub kodujący histonowy trzonek-pętlę i sekwencję poli(A) lub sygnał poliadenylacji do zwiększania ekspresji kodowanego antygenu nowotworowego
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
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JP2015508646A (ja) * 2012-02-15 2015-03-23 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている治療用タンパク質の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸
JP2015508645A (ja) * 2012-02-15 2015-03-23 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている腫瘍抗原の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸
JP2015509363A (ja) * 2012-02-15 2015-03-30 キュアバック ゲーエムベーハーＣｕｒｅｖａｃ Ｇｍｂｈ コードされている病原体抗原の発現を増加させるための、ヒストンステムループとポリ（ａ）配列又はポリアデニル化シグナルとを含むか又はコードしている核酸

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