CY1114911T1 - Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινης και [1,2,4]τριαζολο[1,5-c]πυριμιδινης και χρηση αυτων - Google Patents
Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινης και [1,2,4]τριαζολο[1,5-c]πυριμιδινης και χρηση αυτωνInfo
- Publication number
- CY1114911T1 CY1114911T1 CY20141100147T CY141100147T CY1114911T1 CY 1114911 T1 CY1114911 T1 CY 1114911T1 CY 20141100147 T CY20141100147 T CY 20141100147T CY 141100147 T CY141100147 T CY 141100147T CY 1114911 T1 CY1114911 T1 CY 1114911T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- trizolo
- tyrosine kinase
- receptor tyrosine
- axl receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Η παρούσα εφεύρεση αφορά γενικώς στο πεδίο θεραπευτικών ενώσεων και ειδικότερα σε ορισμένες τριάζολο ενώσεις (που αναφέρονται εδώ ως ΤΑΖ ενώσεις) και ειδικώς ορισμένες ενώσεις [1,2,4]τριαζολο[1,5-a]πυριδίνης και [1,2,4]τριαζολο[1,5-c]πυριμιδίνης, οι οποίες, inter alia, παρεμποδίζουν λειτουργία κινάσης τυροσίνης υποδοχέα AXL. Η παρούσα εφεύρεση αφορά επίσης σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις και τη χρήση τέτοιων ενώσεων και συνθέσεων, τόσο in vitro όσο και in vivo, για να αναστέλλεται λειτουργία κινάσης τυροσίνης υποδοχέα AXL και στη θεραπεία ασθενειών και καταστάσεων που προκαλούνται από κινάση τυροσίνης υποδοχέα AXL, που βελτιώνονται με την αναστολή της λειτουργίας κινάσης τυροσίνης υποδοχέα AXL, κ.λπ., που συμπεριλαμβάνουν πολλαπλασιαστικές καταστάσεις, όπως καρκίνο, κ.λπ.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97879207P | 2007-10-10 | 2007-10-10 | |
GBGB0719803.9A GB0719803D0 (en) | 2007-10-10 | 2007-10-10 | Therapeutic compounds and their use |
EP08806565.1A EP2217578B9 (en) | 2007-10-10 | 2008-10-10 | [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds and their use |
Publications (1)
Publication Number | Publication Date |
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CY1114911T1 true CY1114911T1 (el) | 2016-12-14 |
Family
ID=38787938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20141100147T CY1114911T1 (el) | 2007-10-10 | 2014-02-24 | Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινης και [1,2,4]τριαζολο[1,5-c]πυριμιδινης και χρηση αυτων |
Country Status (11)
Country | Link |
---|---|
US (4) | US8431596B2 (el) |
EP (1) | EP2217578B9 (el) |
CY (1) | CY1114911T1 (el) |
DK (1) | DK2217578T5 (el) |
ES (1) | ES2446298T3 (el) |
GB (1) | GB0719803D0 (el) |
HR (1) | HRP20140191T1 (el) |
PL (1) | PL2217578T3 (el) |
PT (1) | PT2217578E (el) |
SI (1) | SI2217578T1 (el) |
WO (1) | WO2009047514A1 (el) |
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-
2007
- 2007-10-10 GB GBGB0719803.9A patent/GB0719803D0/en not_active Ceased
-
2008
- 2008-10-10 PT PT88065651T patent/PT2217578E/pt unknown
- 2008-10-10 DK DK08806565.1T patent/DK2217578T5/da active
- 2008-10-10 EP EP08806565.1A patent/EP2217578B9/en not_active Revoked
- 2008-10-10 US US12/679,871 patent/US8431596B2/en active Active
- 2008-10-10 SI SI200831148T patent/SI2217578T1/sl unknown
- 2008-10-10 PL PL08806565T patent/PL2217578T3/pl unknown
- 2008-10-10 WO PCT/GB2008/003428 patent/WO2009047514A1/en active Application Filing
- 2008-10-10 ES ES08806565.1T patent/ES2446298T3/es active Active
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2013
- 2013-04-24 US US13/869,374 patent/US9012633B2/en active Active
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2014
- 2014-02-24 CY CY20141100147T patent/CY1114911T1/el unknown
- 2014-03-03 HR HRP20140191AT patent/HRP20140191T1/hr unknown
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2015
- 2015-03-16 US US14/658,437 patent/US9394301B2/en active Active
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- 2016-06-20 US US15/186,689 patent/US9771362B2/en active Active
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Publication number | Publication date |
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US20150246915A1 (en) | 2015-09-03 |
EP2217578A1 (en) | 2010-08-18 |
SI2217578T1 (sl) | 2014-03-31 |
PL2217578T3 (pl) | 2014-05-30 |
US20100298339A1 (en) | 2010-11-25 |
US8431596B2 (en) | 2013-04-30 |
PT2217578E (pt) | 2014-02-17 |
DK2217578T3 (da) | 2014-02-03 |
ES2446298T9 (es) | 2014-09-29 |
EP2217578B9 (en) | 2014-09-10 |
WO2009047514A1 (en) | 2009-04-16 |
ES2446298T3 (es) | 2014-03-07 |
US20170066762A1 (en) | 2017-03-09 |
GB0719803D0 (en) | 2007-11-21 |
HRP20140191T1 (hr) | 2014-04-25 |
EP2217578B1 (en) | 2013-12-04 |
US20140155594A1 (en) | 2014-06-05 |
DK2217578T5 (da) | 2014-11-10 |
US9771362B2 (en) | 2017-09-26 |
US9394301B2 (en) | 2016-07-19 |
US9012633B2 (en) | 2015-04-21 |
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