CY1113194T1 - Συνθεση και αντιϊικη δραστικοτητα παραγωγων υποκατεστημενης αζαϊνδολοοξοοξικης πιπεραζινης - Google Patents

Συνθεση και αντιϊικη δραστικοτητα παραγωγων υποκατεστημενης αζαϊνδολοοξοοξικης πιπεραζινης

Info

Publication number
CY1113194T1
CY1113194T1 CY20121100828T CY121100828T CY1113194T1 CY 1113194 T1 CY1113194 T1 CY 1113194T1 CY 20121100828 T CY20121100828 T CY 20121100828T CY 121100828 T CY121100828 T CY 121100828T CY 1113194 T1 CY1113194 T1 CY 1113194T1
Authority
CY
Cyprus
Prior art keywords
azaidololoxoxic
producers
substitute
substituted
activity
Prior art date
Application number
CY20121100828T
Other languages
Greek (el)
English (en)
Inventor
Tao Wang
Zhongxing Zhang
Nicholas A Meanwell
John F Kadow
Zhiwei Yin
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1113194T1 publication Critical patent/CY1113194T1/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CY20121100828T 2001-02-02 2012-09-12 Συνθεση και αντιϊικη δραστικοτητα παραγωγων υποκατεστημενης αζαϊνδολοοξοοξικης πιπεραζινης CY1113194T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26618301P 2001-02-02 2001-02-02
US31440601P 2001-08-23 2001-08-23
EP02707413A EP1363705B9 (en) 2001-02-02 2002-01-02 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Publications (1)

Publication Number Publication Date
CY1113194T1 true CY1113194T1 (el) 2016-04-13

Family

ID=26951680

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100828T CY1113194T1 (el) 2001-02-02 2012-09-12 Συνθεση και αντιϊικη δραστικοτητα παραγωγων υποκατεστημενης αζαϊνδολοοξοοξικης πιπεραζινης

Country Status (31)

Country Link
US (1) US20030069266A1 (https=)
EP (1) EP1363705B9 (https=)
JP (1) JP4328527B2 (https=)
KR (1) KR20030079979A (https=)
CN (1) CN100384423C (https=)
AR (1) AR034292A1 (https=)
BG (1) BG66359B1 (https=)
BR (1) BRPI0206636B8 (https=)
CA (1) CA2437524C (https=)
CY (1) CY1113194T1 (https=)
CZ (1) CZ303750B6 (https=)
DK (1) DK1363705T3 (https=)
EE (1) EE05424B1 (https=)
ES (1) ES2387981T3 (https=)
HR (1) HRP20030694A2 (https=)
HU (1) HU229305B1 (https=)
IL (2) IL157029A0 (https=)
IS (1) IS2912B (https=)
MX (1) MXPA03006939A (https=)
MY (1) MY137480A (https=)
NO (1) NO326510B1 (https=)
NZ (1) NZ527193A (https=)
PE (1) PE20020855A1 (https=)
PL (1) PL364279A1 (https=)
PT (1) PT1363705E (https=)
RS (1) RS52489B (https=)
RU (1) RU2303038C2 (https=)
SK (1) SK287900B6 (https=)
TW (1) TWI318978B (https=)
WO (1) WO2002062423A1 (https=)
ZA (1) ZA200305885B (https=)

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US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20040162298A1 (en) * 2002-02-23 2004-08-19 Hsu-Tso Ho Method of treating HIV infection by preventing interaction of CD4 and gp120
US7348337B2 (en) 2002-05-28 2008-03-25 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US6900206B2 (en) 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
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US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
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US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
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US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
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US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
US8318941B2 (en) * 2006-07-06 2012-11-27 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
KR20090053923A (ko) * 2006-09-22 2009-05-28 노파르티스 아게 헤테로시클릭 유기 화합물
JP5433691B2 (ja) 2008-06-25 2014-03-05 ブリストル−マイヤーズ スクイブ カンパニー Hiv結合阻害剤としてのジケトピペリジン誘導体
JP5433690B2 (ja) 2008-06-25 2014-03-05 ブリストル−マイヤーズ スクイブ カンパニー 抗−hiv薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン
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EP2751119B1 (en) 2011-08-29 2016-11-23 VIIV Healthcare UK (No.5) Limited Fused bicyclic diamine derivatives as hiv attachment inhibitors
ES2609579T3 (es) 2011-08-29 2017-04-21 VIIV Healthcare UK (No.5) Limited Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH
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Also Published As

Publication number Publication date
BR0206636A (pt) 2004-02-25
PL364279A1 (en) 2004-12-13
EP1363705B1 (en) 2012-06-13
HK1056698A1 (en) 2004-02-27
TWI318978B (en) 2010-01-01
YU60903A (sh) 2006-05-25
EE200300359A (et) 2003-12-15
RS52489B (sr) 2013-02-28
KR20030079979A (ko) 2003-10-10
EP1363705A4 (en) 2009-08-12
HUP0304062A3 (en) 2010-06-28
IS6899A (is) 2003-07-30
BG108021A (bg) 2004-04-30
SK9592003A3 (en) 2004-08-03
MXPA03006939A (es) 2003-11-18
JP2004522755A (ja) 2004-07-29
BG66359B1 (bg) 2013-09-30
AR034292A1 (es) 2004-02-18
ES2387981T3 (es) 2012-10-05
BRPI0206636B8 (pt) 2021-05-25
PE20020855A1 (es) 2002-09-27
IL157029A0 (en) 2004-02-08
EP1363705A1 (en) 2003-11-26
MY137480A (en) 2009-01-30
HUP0304062A2 (hu) 2004-04-28
CA2437524C (en) 2010-04-27
ZA200305885B (en) 2005-01-26
JP4328527B2 (ja) 2009-09-09
HU229305B1 (en) 2013-10-28
DK1363705T3 (da) 2012-09-24
RU2303038C2 (ru) 2007-07-20
IL157029A (en) 2015-11-30
CZ303750B6 (cs) 2013-04-17
PT1363705E (pt) 2012-08-17
NO20033436D0 (no) 2003-08-01
BRPI0206636B1 (pt) 2018-05-02
NZ527193A (en) 2004-05-28
RU2003127077A (ru) 2005-03-20
CN100384423C (zh) 2008-04-30
EP1363705B9 (en) 2012-11-07
NO326510B1 (no) 2008-12-22
WO2002062423A1 (en) 2002-08-15
US20030069266A1 (en) 2003-04-10
CN1612763A (zh) 2005-05-04
HRP20030694A2 (en) 2005-04-30
CA2437524A1 (en) 2002-08-15
EE05424B1 (et) 2011-06-15
CZ20032316A3 (cs) 2004-01-14
IS2912B (is) 2014-11-15
SK287900B6 (sk) 2012-03-02
NO20033436L (no) 2003-10-01

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