CY1110735T1 - 3- ή 4-μονοϋποκατασταθεντα παραγωγα φαινολης και θειοφαινολης χρησιμα ως προσδεματα η3 - Google Patents

3- ή 4-μονοϋποκατασταθεντα παραγωγα φαινολης και θειοφαινολης χρησιμα ως προσδεματα η3

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Publication number
CY1110735T1
CY1110735T1 CY20101100747T CY101100747T CY1110735T1 CY 1110735 T1 CY1110735 T1 CY 1110735T1 CY 20101100747 T CY20101100747 T CY 20101100747T CY 101100747 T CY101100747 T CY 101100747T CY 1110735 T1 CY1110735 T1 CY 1110735T1
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CY
Cyprus
Prior art keywords
useful
phenol
thiophanol
producers
projects
Prior art date
Application number
CY20101100747T
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Greek (el)
English (en)
Inventor
P Bernardelli
Am Cronin
A Denis
Sm Denton
H Jacobelli
Mi Kemp
E Lorthiois
F Rousseau
D Serradeil-Civit
F Vergne
Original Assignee
Warner-Lambert Company Llc
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Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc
Publication of CY1110735T1 publication Critical patent/CY1110735T1/el

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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CY20101100747T 2004-05-07 2010-08-10 3- ή 4-μονοϋποκατασταθεντα παραγωγα φαινολης και θειοφαινολης χρησιμα ως προσδεματα η3 CY1110735T1 (el)

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MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
WO2005066135A2 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
JP2006213674A (ja) * 2005-02-07 2006-08-17 Ube Ind Ltd ４−ホルミルテトラヒドロピラン化合物の製法
CA2957667A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
WO2007045989A1 (en) * 2005-10-20 2007-04-26 Pfizer Limited Pyridyl derivatives useful as h3 ligands
JP5432526B2 (ja) 2006-01-06 2014-03-05 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害剤としてのシクロアルキルアミン
CA2636275C (en) 2006-01-06 2013-02-12 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
US8097760B2 (en) 2006-03-31 2012-01-17 Sunovion Pharmacuticals Inc. Preparation of chiral amides and amines
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US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
CN101610761A (zh) * 2006-12-22 2009-12-23 诺瓦提斯公司 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP3296289A3 (en) 2007-05-31 2018-06-20 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
SG186885A1 (en) 2010-06-04 2013-02-28 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN103906746B (zh) * 2011-10-26 2015-12-09 辉瑞有限公司 用作钠通道调节剂的(4-苯基咪唑-2-基)乙胺衍生物
WO2014095534A1 (en) * 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
ES2647965T3 (es) * 2013-01-09 2017-12-27 Arena Pharmaceuticals, Inc. Derivados de bifenil-etil-pirrolidina como moduladores del receptor de histamina H3 para el tratamiento de trastornos cognitivos
TWI663159B (zh) * 2013-12-10 2019-06-21 美商健臻公司 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
SG11201704872RA (en) 2014-12-18 2017-07-28 Genzyme Corp Pharmaceutical formulations of tropomyosin related kinase (trk) inhibitors
CN113336715B (zh) * 2021-08-04 2021-11-23 山东海利尔化工有限公司 一种含二氧戊环的三唑类化合物及其中间体的制备方法

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DE3024836A1 (de) * 1980-07-01 1982-01-28 A. Nattermann & Cie GmbH, 5000 Köln (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel
DK368687A (da) * 1986-11-21 1988-05-22 Cheminova As Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
ATE372981T1 (de) * 2000-07-13 2007-09-15 Abbott Lab 1,3-disubstituierte und 1,3,3-trisubstituierte pyrrolidine als liganden des histamin-3 rezeptors und ihre therapeutischen anwendungen
ES2282279T3 (es) * 2000-08-08 2007-10-16 Ortho-Mcneil Pharmaceutical, Inc. No-imidazol ariloxipiperidina como ligandos del receptor h3.
CA2441080A1 (en) * 2001-03-23 2002-10-03 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses

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