PE20060237A1 - Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3 - Google Patents

Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3

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Publication number
PE20060237A1
PE20060237A1 PE2005000505A PE2005000505A PE20060237A1 PE 20060237 A1 PE20060237 A1 PE 20060237A1 PE 2005000505 A PE2005000505 A PE 2005000505A PE 2005000505 A PE2005000505 A PE 2005000505A PE 20060237 A1 PE20060237 A1 PE 20060237A1
Authority
PE
Peru
Prior art keywords
monosustituted
thiophenol
ligands
phenol
derivatives
Prior art date
Application number
PE2005000505A
Other languages
English (en)
Inventor
Patrick Bernardelli
Andrew Michael Cronin
Stephen Martin Denton
Mark Ian Kemp
Fiona Rousseau
Fabrice Vergne
Delphine Serradeil-Civit
Edwige Lorthiois
Henry Jacobelli
Alexis Denis
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20060237A1 publication Critical patent/PE20060237A1/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE EL SUSTITUYENTE -Z-R ESTA EN POSICION META O PARA DEL GRUPO FENILO; X SE SELECCIONA ENTRE -CN, -CH2OH, -CH2-O-(ALQUILOC1-C4), -C(O)OH, ENTRE OTROS; Y ES CH2, CH(OH), O, C=O, N, ENTRE OTROS; Z ES O, S, SO, SO2; m Y p SON CADA UNO 1-3, CON LA CONDICION DE QUE m+p SEA IGUAL O MENOR QUE 4. SON COMPUESTOS PREFERIDOS: DIMETIL-{4-[3-(3-PIRROLIDIN-1-ILPROPOXI)FENIL]TETRAHIDRO-PIRAN-4-ILMETIL}AMINA; 1-{3-[4-(4-DIMETILAMINOMETIL-TETRAHIDRO-PIRAN-4-IL)-FENOXI]-PROPIL}-PIPERIDIN-4-OL; 2-(1-{3-[4-(4-DIMETILAMINOMETILTETRAHIDROPIRAN-4-IL)FENOXI]PROPIL}PIPERIDIN-4-IL)ETANOL; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DE LOS RECEPTORES DE HISTAMINA H3 UTIELS EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y TRASTORNOS INFLAMATORIOS
PE2005000505A 2004-05-07 2005-05-04 Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3 PE20060237A1 (es)

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