BRPI0510664A - derivados de fenol e tiofenol 3 ou 4-monosubstituìdo úteis como ligantes de h3 - Google Patents

derivados de fenol e tiofenol 3 ou 4-monosubstituìdo úteis como ligantes de h3

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Publication number
BRPI0510664A
BRPI0510664A BRPI0510664-8A BRPI0510664A BRPI0510664A BR PI0510664 A BRPI0510664 A BR PI0510664A BR PI0510664 A BRPI0510664 A BR PI0510664A BR PI0510664 A BRPI0510664 A BR PI0510664A
Authority
BR
Brazil
Prior art keywords
binders
derivatives
phenol
thiophenol
derivatives useful
Prior art date
Application number
BRPI0510664-8A
Other languages
English (en)
Inventor
Patrick Bernardelli
Andrew Michael Cronin
Alexis Denis
Stephen Martin Denton
Henry Jacobelli
Mark Ian Kemp
Edwige Lorthiois
Fiona Rousseau
Delphine Serradeil-Civit
Fabrice Vergne
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0510664A publication Critical patent/BRPI0510664A/pt
Publication of BRPI0510664B1 publication Critical patent/BRPI0510664B1/pt
Publication of BRPI0510664B8 publication Critical patent/BRPI0510664B8/pt

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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

DERIVADOS DE FENOL E TIOFENOL 3 OU 4-MONO-SUBSTITUìDO úTEIS COMO LIGANTES DE H~ 3~ A invenção diz respeito a derivados fenol e tiofenol 3 ou 4 mono-substituídos da fórmula (1) e a processos para a preparação de tais derivados, intermediários usados na sua preparação, composições contendo tais derivados e usos de tais derivados. Os ditos derivados fenol e tiofenol 3 ou 4 mono-substituídos são ligantes de H~ 3~ e são usados em inúmeras doenças, distúrbios e condições, em particular, doenças, distúrbios e condições inflamatórias, alérgicas e respiratórias.
BRPI0510664A 2004-05-07 2005-04-19 derivados de fenol e tiofenol 3 ou 4-monosubstituído, composição farmacêutica, combinação e uso dos compostos para tratamento de doenças relacionadas ao h3, incluindo transtornos do sistema nervoso central e transtornos inflamatórios BRPI0510664B8 (pt)

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EP04291187A EP1593679A1 (en) 2004-05-07 2004-05-07 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
GB0504564A GB0504564D0 (en) 2005-03-04 2005-03-04 New compounds
PCT/IB2005/001114 WO2005108384A1 (en) 2004-05-07 2005-04-19 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands

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HRP20100469T1 (hr) 2010-10-31
EP1747210A1 (en) 2007-01-31
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