BRPI0712064B8 - derivados de (2r)-2-fenilpropanamida, uso e processo para preparação dos mesmos e composições farmacêuticas - Google Patents
derivados de (2r)-2-fenilpropanamida, uso e processo para preparação dos mesmos e composições farmacêuticasInfo
- Publication number
- BRPI0712064B8 BRPI0712064B8 BRPI0712064A BRPI0712064A BRPI0712064B8 BR PI0712064 B8 BRPI0712064 B8 BR PI0712064B8 BR PI0712064 A BRPI0712064 A BR PI0712064A BR PI0712064 A BRPI0712064 A BR PI0712064A BR PI0712064 B8 BRPI0712064 B8 BR PI0712064B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- preparation
- useful
- treatment
- phenylpropanamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
derivados de (2r)-2-fenilpropanamida, uso e processo para preparação dos mesmos e composições farmacêuticas. a presente invenção refere-se a novas (2r)-2-fenilpropanamidas que transportam um substituinte 4-sulfonilamino na posição 4 do grupo fenila e a composições farmacêuticas que as contêm, que são usadas como inibidores da quimiotaxia de células polimorfonucleadas e mononucleadas, e que são úteis no tratamento de vários distúrbios mediados pela quimiocina el-r+cxc. em particular, os compostos da invenção são úteis no tratamento e controle de patologias específicas dependentes de cxcr2 tais como bos, copd, angiogênese e melanoma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06114185.9 | 2006-05-18 | ||
EP06114185 | 2006-05-18 | ||
PCT/EP2007/054806 WO2007135080A2 (en) | 2006-05-18 | 2007-05-17 | (2r)-2-[(4-sulfonyl)aminophenyl]propanamides and pharmaceutical compositions containing them |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0712064A2 BRPI0712064A2 (pt) | 2011-12-20 |
BRPI0712064B1 BRPI0712064B1 (pt) | 2020-10-20 |
BRPI0712064B8 true BRPI0712064B8 (pt) | 2021-05-25 |
Family
ID=38353147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0712064A BRPI0712064B8 (pt) | 2006-05-18 | 2007-05-17 | derivados de (2r)-2-fenilpropanamida, uso e processo para preparação dos mesmos e composições farmacêuticas |
Country Status (23)
Country | Link |
---|---|
US (2) | US7652169B2 (pt) |
EP (1) | EP2024329B1 (pt) |
JP (1) | JP5161873B2 (pt) |
KR (1) | KR101422299B1 (pt) |
CN (1) | CN101448784B (pt) |
AU (1) | AU2007253424B2 (pt) |
BR (1) | BRPI0712064B8 (pt) |
CA (1) | CA2649794C (pt) |
CY (1) | CY1114532T1 (pt) |
DK (1) | DK2024329T3 (pt) |
ES (1) | ES2433095T3 (pt) |
HK (1) | HK1131380A1 (pt) |
HR (1) | HRP20130989T1 (pt) |
IL (1) | IL194939A (pt) |
MX (1) | MX2008013957A (pt) |
NZ (1) | NZ572075A (pt) |
PL (1) | PL2024329T3 (pt) |
PT (1) | PT2024329E (pt) |
RS (1) | RS53007B (pt) |
RU (1) | RU2457201C2 (pt) |
SI (1) | SI2024329T1 (pt) |
WO (1) | WO2007135080A2 (pt) |
ZA (1) | ZA200808907B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2166006A1 (en) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
KR101298651B1 (ko) * | 2011-03-16 | 2013-08-21 | 연세대학교 산학협력단 | 효능이 강화된 혈관신생 억제용 약제학적 조성물 |
CN103159674A (zh) * | 2013-04-03 | 2013-06-19 | 苏州安诺生物医药技术有限公司 | 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途 |
US10301378B2 (en) | 2013-06-18 | 2019-05-28 | New York University | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets |
EP3174851A1 (en) * | 2014-07-31 | 2017-06-07 | GlaxoSmithKline Intellectual Property Management Limited | Use of cxcr2 antagonists for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (cipn) |
EP3884932A1 (en) | 2020-03-26 | 2021-09-29 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
IL296751A (en) | 2020-03-26 | 2022-11-01 | Dompe Farm Spa | cxcl8 inhibitors for use in the treatment of covid-19 |
EP4008325A1 (en) | 2020-12-02 | 2022-06-08 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN188162B (pt) * | 1999-02-05 | 2002-08-31 | Torrent Pharmaceuticals Ltd | |
IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
ITMI20012434A1 (it) * | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
EP1457485A1 (en) * | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
KR100707123B1 (ko) * | 2003-07-02 | 2007-04-16 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물 |
EP1776336B1 (en) * | 2004-03-23 | 2009-09-30 | DOMPE' pha.r.ma s.p.a. | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them |
MX2007007133A (es) * | 2004-12-15 | 2007-08-08 | Dompe Pha R Ma Spa Res & Mfg | Derivados de acido 2-arilpropionico y composiciones farmaceuticas que los contienen. |
-
2007
- 2007-05-17 CN CN2007800179024A patent/CN101448784B/zh active Active
- 2007-05-17 PL PL07729254T patent/PL2024329T3/pl unknown
- 2007-05-17 CA CA2649794A patent/CA2649794C/en active Active
- 2007-05-17 NZ NZ572075A patent/NZ572075A/en unknown
- 2007-05-17 MX MX2008013957A patent/MX2008013957A/es active IP Right Grant
- 2007-05-17 AU AU2007253424A patent/AU2007253424B2/en active Active
- 2007-05-17 SI SI200731344T patent/SI2024329T1/sl unknown
- 2007-05-17 EP EP07729254.8A patent/EP2024329B1/en active Active
- 2007-05-17 RU RU2008149936/04A patent/RU2457201C2/ru active
- 2007-05-17 BR BRPI0712064A patent/BRPI0712064B8/pt active IP Right Grant
- 2007-05-17 ES ES07729254T patent/ES2433095T3/es active Active
- 2007-05-17 US US12/227,519 patent/US7652169B2/en active Active
- 2007-05-17 JP JP2009510463A patent/JP5161873B2/ja active Active
- 2007-05-17 RS RS20130467A patent/RS53007B/en unknown
- 2007-05-17 PT PT77292548T patent/PT2024329E/pt unknown
- 2007-05-17 KR KR1020087027557A patent/KR101422299B1/ko active IP Right Grant
- 2007-05-17 WO PCT/EP2007/054806 patent/WO2007135080A2/en active Application Filing
- 2007-05-17 DK DK07729254.8T patent/DK2024329T3/da active
- 2007-05-17 ZA ZA200808907A patent/ZA200808907B/xx unknown
-
2008
- 2008-10-27 IL IL194939A patent/IL194939A/en active IP Right Grant
-
2009
- 2009-10-30 HK HK09110159.7A patent/HK1131380A1/xx unknown
- 2009-12-15 US US12/653,599 patent/US7868046B2/en active Active
-
2013
- 2013-10-21 HR HRP20130989TT patent/HRP20130989T1/hr unknown
- 2013-10-25 CY CY20131100949T patent/CY1114532T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0712064B8 (pt) | derivados de (2r)-2-fenilpropanamida, uso e processo para preparação dos mesmos e composições farmacêuticas | |
BRPI0609719B8 (pt) | derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2 | |
SE0301010D0 (sv) | Novel compounds | |
BRPI0508724A (pt) | derivados do fenilaminoetanol como agonistas do receptor beta2 | |
SE0301009D0 (sv) | Novel compounds | |
BRPI0510453A (pt) | composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central | |
BRPI0510664A (pt) | derivados de fenol e tiofenol 3 ou 4-monosubstituìdo úteis como ligantes de h3 | |
BRPI0606964A2 (pt) | pirrolidinas e piperidinas derivadas do acetileno para uso como antagonistas de mglur5 | |
BRPI0509369A (pt) | azaindóis úteis como inibidores de jak e outras proteìna cinases | |
BRPI0709633B8 (pt) | derivados de piridina e pirimidina como antagonistas de mglur2, composição farmacêutica e uso dos mesmos | |
BRPI0507041A (pt) | composto derivados de sulfonamida para o tratamento de doenças seus usos, processo para a preparação dos compostos e combinação de compostos | |
BRPI0717970C1 (pt) | composto inibidor de 11betahsd1, composição farmacêutica, e, uso do composto | |
BRPI0507481A (pt) | composto, composição farmacêutica, uso do composto, e, métodos para tratar distúrbios mediados por mglur 5 e para inibir ativação de receptores de mglur 5 | |
BRPI0314325B8 (pt) | derivados de aza-bicicloalquila, seu uso, seu processo de preparação e composição farmacêutica que os compreende | |
BRPI0415683A (pt) | inibidores da reabsorção de norepinefrina para o tratamento de distúrbios do sistema nervoso central | |
NO20064160L (no) | Nye azaibicykliske forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem | |
BRPI0515081A (pt) | derivados de fenilaminopirimidina como inibidores de bcr-abl cinase | |
BRPI0507085A (pt) | derivados de sulfonamida, composição farmacêutica, usos, processos para preparação e combinação | |
BRPI0508622B8 (pt) | compostos de bifenil úteis como antagonistas do receptor muscarínico, composição farmacêutica, processo, medicamento e uso do composto. | |
HRP20050735B1 (hr) | Dihidropteridinoni, metoda za njihovu proizvodnju i upotrebu u obliku lijekova | |
BRPI0507839A (pt) | derivados tetraidroisoquinolinil de quinazolina e isoquinolina | |
BR0206433A (pt) | Composto, composição farmacêutica, processo para a prepapação de um composto, e, uso de um composto | |
BRPI0713443A2 (pt) | Derivados de piperazinila úteis no tratamento de doenças medianas por receptor gpr38, uso e composição farmacêutica contendo tais compostos e processos para preparação dos mesmos | |
NO20084712L (no) | Nye farmasoytiske forbindelser | |
NO20085212L (no) | Nye pyridinanaloger |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: DOMPE' S.P.A. (IT) Free format text: TRANSFERIDO POR FUSAO DE: DOMPE PHA.R.MA S.P.A. |
|
B25A | Requested transfer of rights approved |
Owner name: DOMPE FARMACEUTICI S.P.A (IT) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/05/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |