KR100843848B1 - H3 리간드로서 유용한 3- 또는 4-단일치환된 페놀 및싸이오페놀 유도체 - Google Patents
H3 리간드로서 유용한 3- 또는 4-단일치환된 페놀 및싸이오페놀 유도체 Download PDFInfo
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- KR100843848B1 KR100843848B1 KR1020067023284A KR20067023284A KR100843848B1 KR 100843848 B1 KR100843848 B1 KR 100843848B1 KR 1020067023284 A KR1020067023284 A KR 1020067023284A KR 20067023284 A KR20067023284 A KR 20067023284A KR 100843848 B1 KR100843848 B1 KR 100843848B1
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- Prior art keywords
- phenyl
- pyran
- tetrahydro
- methyl
- pyrrolidin
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- 0 N=C*1CCCCC1 Chemical compound N=C*1CCCCC1 0.000 description 9
- HCGITLJZDQEJPA-UHFFFAOYSA-N CC(C)N(CC1)CCC1Oc1ccc(C2(CCOCC2)C(N2CCC2)=O)cc1 Chemical compound CC(C)N(CC1)CCC1Oc1ccc(C2(CCOCC2)C(N2CCC2)=O)cc1 HCGITLJZDQEJPA-UHFFFAOYSA-N 0.000 description 1
- OOAPQINQOLWPEV-UHFFFAOYSA-N CCN(C)CCCOc1ccc(C2(CN3CCOCC3)CCOCC2)cc1 Chemical compound CCN(C)CCCOc1ccc(C2(CN3CCOCC3)CCOCC2)cc1 OOAPQINQOLWPEV-UHFFFAOYSA-N 0.000 description 1
- BTAOKUXGKDKTIR-UHFFFAOYSA-N CCN(CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)C(C)=O Chemical compound CCN(CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)C(C)=O BTAOKUXGKDKTIR-UHFFFAOYSA-N 0.000 description 1
- IRQWCOFOSMREBQ-UHFFFAOYSA-N CN(C)C1CNC1 Chemical compound CN(C)C1CNC1 IRQWCOFOSMREBQ-UHFFFAOYSA-N 0.000 description 1
- HPLCRROSPJXLHU-UHFFFAOYSA-N CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN(CC1)CCC1C(N)=O Chemical compound CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN(CC1)CCC1C(N)=O HPLCRROSPJXLHU-UHFFFAOYSA-N 0.000 description 1
- QPQBUHKKPZDZER-UHFFFAOYSA-N CN(CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)S(C)(=O)=O Chemical compound CN(CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)S(C)(=O)=O QPQBUHKKPZDZER-UHFFFAOYSA-N 0.000 description 1
- LSYDVIMXNCBKNG-UHFFFAOYSA-N CN(CCO)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1 Chemical compound CN(CCO)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1 LSYDVIMXNCBKNG-UHFFFAOYSA-N 0.000 description 1
- GCNIGYALSOMQJX-UHFFFAOYSA-N COCCN(CC1)CCC1(c(cc1)ccc1OCCCN1CCCC1)C#N Chemical compound COCCN(CC1)CCC1(c(cc1)ccc1OCCCN1CCCC1)C#N GCNIGYALSOMQJX-UHFFFAOYSA-N 0.000 description 1
- RKRUGRFQMMFERN-UHFFFAOYSA-N C[n]1c(NCC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)nc2ccccc12 Chemical compound C[n]1c(NCC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)nc2ccccc12 RKRUGRFQMMFERN-UHFFFAOYSA-N 0.000 description 1
- YJPDOIPIOIUSCV-UHFFFAOYSA-N N#CC1(CCCC1)c(cc1)ccc1OCCCN1CCCC1 Chemical compound N#CC1(CCCC1)c(cc1)ccc1OCCCN1CCCC1 YJPDOIPIOIUSCV-UHFFFAOYSA-N 0.000 description 1
- HRYSFDVGRQYADA-UHFFFAOYSA-N N#CC1(CCOCC1)c(cc1)ccc1OC(CC1)CCN1C1CCCC1 Chemical compound N#CC1(CCOCC1)c(cc1)ccc1OC(CC1)CCN1C1CCCC1 HRYSFDVGRQYADA-UHFFFAOYSA-N 0.000 description 1
- GWKSUDJAXWYYKI-UHFFFAOYSA-N O=S(Cc1ccccc1)(NCC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O Chemical compound O=S(Cc1ccccc1)(NCC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O GWKSUDJAXWYYKI-UHFFFAOYSA-N 0.000 description 1
- ASPKIWTUTQSIMZ-UHFFFAOYSA-N O=S1(CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1)=O Chemical compound O=S1(CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1)=O ASPKIWTUTQSIMZ-UHFFFAOYSA-N 0.000 description 1
- BXEFFAYYUZKPQL-UHFFFAOYSA-N OCC1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1 Chemical compound OCC1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1 BXEFFAYYUZKPQL-UHFFFAOYSA-N 0.000 description 1
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| EP04291187A EP1593679A1 (en) | 2004-05-07 | 2004-05-07 | 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands |
| EP04291187.5 | 2004-05-07 | ||
| GB0504564A GB0504564D0 (en) | 2005-03-04 | 2005-03-04 | New compounds |
| GB0504564.6 | 2005-03-04 |
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| KR20060133091A KR20060133091A (ko) | 2006-12-22 |
| KR100843848B1 true KR100843848B1 (ko) | 2008-07-03 |
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| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| WO2005066135A2 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| JP2006213674A (ja) * | 2005-02-07 | 2006-08-17 | Ube Ind Ltd | 4−ホルミルテトラヒドロピラン化合物の製法 |
| CA2957667A1 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| WO2007045989A1 (en) * | 2005-10-20 | 2007-04-26 | Pfizer Limited | Pyridyl derivatives useful as h3 ligands |
| JP5432526B2 (ja) | 2006-01-06 | 2014-03-05 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害剤としてのシクロアルキルアミン |
| CA2636275C (en) | 2006-01-06 | 2013-02-12 | Sepracor Inc. | Tetralone-based monoamine reuptake inhibitors |
| US8097760B2 (en) | 2006-03-31 | 2012-01-17 | Sunovion Pharmacuticals Inc. | Preparation of chiral amides and amines |
| EP2007723A2 (en) | 2006-04-11 | 2008-12-31 | Novartis AG | Organic compounds |
| KR20090024811A (ko) | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 h3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| CN101610761A (zh) * | 2006-12-22 | 2009-12-23 | 诺瓦提斯公司 | 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物 |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| EP3296289A3 (en) | 2007-05-31 | 2018-06-20 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| TW201039822A (en) | 2009-02-06 | 2010-11-16 | Taisho Pharmaceutical Co Ltd | Dihydroquinolinone derivatives |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN103906746B (zh) * | 2011-10-26 | 2015-12-09 | 辉瑞有限公司 | 用作钠通道调节剂的(4-苯基咪唑-2-基)乙胺衍生物 |
| WO2014095534A1 (en) * | 2012-12-19 | 2014-06-26 | Basf Se | New substituted triazoles and imidazoles and their use as fungicides |
| ES2647965T3 (es) * | 2013-01-09 | 2017-12-27 | Arena Pharmaceuticals, Inc. | Derivados de bifenil-etil-pirrolidina como moduladores del receptor de histamina H3 para el tratamiento de trastornos cognitivos |
| TWI663159B (zh) * | 2013-12-10 | 2019-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
| SG11201704872RA (en) | 2014-12-18 | 2017-07-28 | Genzyme Corp | Pharmaceutical formulations of tropomyosin related kinase (trk) inhibitors |
| CN113336715B (zh) * | 2021-08-04 | 2021-11-23 | 山东海利尔化工有限公司 | 一种含二氧戊环的三唑类化合物及其中间体的制备方法 |
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| WO2002006223A1 (en) * | 2000-07-13 | 2002-01-24 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| WO2002012190A2 (en) * | 2000-08-08 | 2002-02-14 | Ortho Mcneil Pharmaceutical, Inc. | Non-imidazole aryloxypiperidines as h3 receptor ligands |
| WO2002076925A2 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
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| DE3024836A1 (de) * | 1980-07-01 | 1982-01-28 | A. Nattermann & Cie GmbH, 5000 Köln | (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel |
| DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
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| WO2002006223A1 (en) * | 2000-07-13 | 2002-01-24 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| WO2002012190A2 (en) * | 2000-08-08 | 2002-02-14 | Ortho Mcneil Pharmaceutical, Inc. | Non-imidazole aryloxypiperidines as h3 receptor ligands |
| WO2002076925A2 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
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