CN1950351B - 适用作h3配体的3-或4-单取代酚及苯硫酚衍生物 - Google Patents
适用作h3配体的3-或4-单取代酚及苯硫酚衍生物 Download PDFInfo
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- CN1950351B CN1950351B CN2005800146623A CN200580014662A CN1950351B CN 1950351 B CN1950351 B CN 1950351B CN 2005800146623 A CN2005800146623 A CN 2005800146623A CN 200580014662 A CN200580014662 A CN 200580014662A CN 1950351 B CN1950351 B CN 1950351B
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- alkyl
- phenyl
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- pyran
- tetrahydro
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- 0 CCOC(N1CCN(CCCOC2C=CC(C3(CN(C)C)*COCC3)=CC2)CC1)=O Chemical compound CCOC(N1CCN(CCCOC2C=CC(C3(CN(C)C)*COCC3)=CC2)CC1)=O 0.000 description 7
- SPYCOQPCVRMLDA-YOVMUDTDSA-N C/C=C(\C=C/C(C1(CN(C)C(N(C)C)=O)CCOCC1)=C)/OCCCN1CCCC1 Chemical compound C/C=C(\C=C/C(C1(CN(C)C(N(C)C)=O)CCOCC1)=C)/OCCCN1CCCC1 SPYCOQPCVRMLDA-YOVMUDTDSA-N 0.000 description 1
- FIFUBMMWDKBRMU-UHFFFAOYSA-N CC(N(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O Chemical compound CC(N(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O FIFUBMMWDKBRMU-UHFFFAOYSA-N 0.000 description 1
- AOTNOVXRGAHCFL-VDEHPEQNSA-N CCNCC1(CCOCC1)/C(/C#C)=C/C=C(\C)/OCCCN1CCCC1 Chemical compound CCNCC1(CCOCC1)/C(/C#C)=C/C=C(\C)/OCCCN1CCCC1 AOTNOVXRGAHCFL-VDEHPEQNSA-N 0.000 description 1
- UOXUQDQCNSXUOO-UHFFFAOYSA-N CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCC(CCO)CC1 Chemical compound CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCC(CCO)CC1 UOXUQDQCNSXUOO-UHFFFAOYSA-N 0.000 description 1
- JYNIFNSNENUZCW-UHFFFAOYSA-N CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCOCC1 Chemical compound CN(C)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCOCC1 JYNIFNSNENUZCW-UHFFFAOYSA-N 0.000 description 1
- SXJFAJJSPKVMAN-UHFFFAOYSA-N CN(C)S(NCC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)(=O)=O Chemical compound CN(C)S(NCC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)(=O)=O SXJFAJJSPKVMAN-UHFFFAOYSA-N 0.000 description 1
- BTVUTTWFHPBVGZ-UHFFFAOYSA-N CN(CCOC)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1 Chemical compound CN(CCOC)CC1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1 BTVUTTWFHPBVGZ-UHFFFAOYSA-N 0.000 description 1
- QUNUESAMZQXTKG-UHFFFAOYSA-N NC(N1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1)=O Chemical compound NC(N1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1)=O QUNUESAMZQXTKG-UHFFFAOYSA-N 0.000 description 1
- VGNXQHOEODSTIS-UHFFFAOYSA-N O=C(CCC1)N1C1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1 Chemical compound O=C(CCC1)N1C1CCN(CC2(CCOCC2)c(cc2)ccc2OCCCN2CCCC2)CC1 VGNXQHOEODSTIS-UHFFFAOYSA-N 0.000 description 1
- MSNKLEMTHNAVNT-UHFFFAOYSA-N OC(C1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O Chemical compound OC(C1(CCOCC1)c(cc1)ccc1OCCCN1CCCC1)=O MSNKLEMTHNAVNT-UHFFFAOYSA-N 0.000 description 1
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04291187A EP1593679A1 (en) | 2004-05-07 | 2004-05-07 | 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands |
| EP04291187.5 | 2004-05-07 | ||
| GB0504564A GB0504564D0 (en) | 2005-03-04 | 2005-03-04 | New compounds |
| GB0504564.6 | 2005-03-04 | ||
| PCT/IB2005/001114 WO2005108384A1 (en) | 2004-05-07 | 2005-04-19 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1950351A CN1950351A (zh) | 2007-04-18 |
| CN1950351B true CN1950351B (zh) | 2012-01-18 |
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| CN2005800146623A Expired - Fee Related CN1950351B (zh) | 2004-05-07 | 2005-04-19 | 适用作h3配体的3-或4-单取代酚及苯硫酚衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| WO2005066135A2 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| JP2006213674A (ja) * | 2005-02-07 | 2006-08-17 | Ube Ind Ltd | 4−ホルミルテトラヒドロピラン化合物の製法 |
| CA2957667A1 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| WO2007045989A1 (en) * | 2005-10-20 | 2007-04-26 | Pfizer Limited | Pyridyl derivatives useful as h3 ligands |
| JP5432526B2 (ja) | 2006-01-06 | 2014-03-05 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害剤としてのシクロアルキルアミン |
| CA2636275C (en) | 2006-01-06 | 2013-02-12 | Sepracor Inc. | Tetralone-based monoamine reuptake inhibitors |
| US8097760B2 (en) | 2006-03-31 | 2012-01-17 | Sunovion Pharmacuticals Inc. | Preparation of chiral amides and amines |
| EP2007723A2 (en) | 2006-04-11 | 2008-12-31 | Novartis AG | Organic compounds |
| KR20090024811A (ko) | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 h3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| CN101610761A (zh) * | 2006-12-22 | 2009-12-23 | 诺瓦提斯公司 | 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物 |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| EP3296289A3 (en) | 2007-05-31 | 2018-06-20 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| TW201039822A (en) | 2009-02-06 | 2010-11-16 | Taisho Pharmaceutical Co Ltd | Dihydroquinolinone derivatives |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN103906746B (zh) * | 2011-10-26 | 2015-12-09 | 辉瑞有限公司 | 用作钠通道调节剂的(4-苯基咪唑-2-基)乙胺衍生物 |
| WO2014095534A1 (en) * | 2012-12-19 | 2014-06-26 | Basf Se | New substituted triazoles and imidazoles and their use as fungicides |
| ES2647965T3 (es) * | 2013-01-09 | 2017-12-27 | Arena Pharmaceuticals, Inc. | Derivados de bifenil-etil-pirrolidina como moduladores del receptor de histamina H3 para el tratamiento de trastornos cognitivos |
| TWI663159B (zh) * | 2013-12-10 | 2019-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
| SG11201704872RA (en) | 2014-12-18 | 2017-07-28 | Genzyme Corp | Pharmaceutical formulations of tropomyosin related kinase (trk) inhibitors |
| CN113336715B (zh) * | 2021-08-04 | 2021-11-23 | 山东海利尔化工有限公司 | 一种含二氧戊环的三唑类化合物及其中间体的制备方法 |
Family Cites Families (5)
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| DE3024836A1 (de) * | 1980-07-01 | 1982-01-28 | A. Nattermann & Cie GmbH, 5000 Köln | (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel |
| DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
| ATE372981T1 (de) * | 2000-07-13 | 2007-09-15 | Abbott Lab | 1,3-disubstituierte und 1,3,3-trisubstituierte pyrrolidine als liganden des histamin-3 rezeptors und ihre therapeutischen anwendungen |
| ES2282279T3 (es) * | 2000-08-08 | 2007-10-16 | Ortho-Mcneil Pharmaceutical, Inc. | No-imidazol ariloxipiperidina como ligandos del receptor h3. |
| CA2441080A1 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
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