CY1113617T1 - Νεα παραγωγα φαινυλαμινοπυριμιδινης ως αναστολεις της κινασης bcr-abl - Google Patents
Νεα παραγωγα φαινυλαμινοπυριμιδινης ως αναστολεις της κινασης bcr-ablInfo
- Publication number
- CY1113617T1 CY1113617T1 CY20121100895T CY121100895T CY1113617T1 CY 1113617 T1 CY1113617 T1 CY 1113617T1 CY 20121100895 T CY20121100895 T CY 20121100895T CY 121100895 T CY121100895 T CY 121100895T CY 1113617 T1 CY1113617 T1 CY 1113617T1
- Authority
- CY
- Cyprus
- Prior art keywords
- new
- derivatives
- novel
- phenylaminopyrimidine derivatives
- abl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
Η τρέχουσα εφεύρεση σχετίζεται με τα νέα ενδιάμεσα προϊόντα που χρησιμεύουν για την παρασκευή νέων παραγώγων φαινυλαμινοπυριμιδίνης, νέων παραγώγων φαινυλαμινοπυριμιδίνης. Η φαρμακευτική σύνθεση που περιέχει τα νέα παράγωγα φαινυλαμινοπυριμιδίνης και διαδικασίες για την παρασκευή τους. Η εφεύρεση σχετίζεται ιδιαίτερα με τα νέα παράγωγα φαινυλικής πυριμιδιναμίνης του γενικού τύπου (I). Οι νέες ενώσεις του τύπου 1 μπορούν να χρησιμοποιηθούν στη θεραπεία της Χρόνιας Μυολεγενούς Λευχαιμίας (ΧΜΛ). Καθώς οι τιμές IC50 191 των εν λόγω μορίων κυμαίνονται από 0,1 έως 10,0 nm, αυτές οι νέες ενώσεις είναι πιθανώς χρήσιμες για τη θεραπεία της ΧΜΛ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN908CH2004 | 2004-09-09 | ||
EP05779775A EP1786799B1 (en) | 2004-09-09 | 2005-07-19 | Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113617T1 true CY1113617T1 (el) | 2016-06-22 |
Family
ID=35395645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100895T CY1113617T1 (el) | 2004-09-09 | 2012-09-28 | Νεα παραγωγα φαινυλαμινοπυριμιδινης ως αναστολεις της κινασης bcr-abl |
Country Status (26)
Country | Link |
---|---|
US (2) | US7910598B2 (el) |
EP (2) | EP1786799B1 (el) |
JP (1) | JP5184887B2 (el) |
KR (1) | KR100948453B1 (el) |
CN (1) | CN101068805B (el) |
AP (1) | AP2470A (el) |
AU (1) | AU2005281299B2 (el) |
BR (1) | BRPI0515081B8 (el) |
CA (1) | CA2591321C (el) |
CY (1) | CY1113617T1 (el) |
DK (1) | DK1786799T3 (el) |
EA (1) | EA013328B1 (el) |
ES (1) | ES2390227T3 (el) |
HK (1) | HK1110588A1 (el) |
HR (1) | HRP20070146B1 (el) |
IL (1) | IL181811A (el) |
MA (1) | MA28922B1 (el) |
MX (1) | MX2007002819A (el) |
NO (1) | NO337598B1 (el) |
NZ (1) | NZ554361A (el) |
PL (1) | PL1786799T3 (el) |
PT (1) | PT1786799E (el) |
SI (1) | SI1786799T1 (el) |
UA (1) | UA94570C2 (el) |
WO (1) | WO2006027795A1 (el) |
ZA (2) | ZA200701942B (el) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US7932260B2 (en) | 2004-05-13 | 2011-04-26 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
US8735415B2 (en) | 2004-09-09 | 2014-05-27 | Natco Pharma Limited | Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
US7939541B2 (en) * | 2004-09-09 | 2011-05-10 | Natco Pharma Limited | Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
US20110190328A1 (en) * | 2004-09-09 | 2011-08-04 | Natco Pharma Limited | Acid addition salts of (3,5-bis trifluoromethyl)-n-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
MX2007002819A (es) | 2004-09-09 | 2007-08-14 | Natco Pharma Ltd | Nuevos derivados de fenilaminopirimidina como inhibidores de bcl-abl cinasa. |
WO2008031534A1 (en) * | 2006-09-11 | 2008-03-20 | Syngenta Participations Ag | Insecticidal compounds |
BRPI0718677A2 (pt) * | 2006-11-03 | 2013-11-26 | Irm Llc | Compostos e composições como inibidores de quinases proteicas |
SG177200A1 (en) * | 2006-12-14 | 2012-01-30 | Bayer Schering Pharma Ag | Dihydropyridine derivatives useful as protein kinase inhibitors |
ATE544761T1 (de) * | 2007-05-04 | 2012-02-15 | Irm Llc | Pyrimidinderivate und zusammensetzungen als c-kit-und pdgfr-kinasehemmer |
WO2008137794A1 (en) * | 2007-05-04 | 2008-11-13 | Irm Llc | Compounds and compositions as c-kit and pdgfr kinase inhibitors |
BRPI0815572A2 (pt) | 2007-08-22 | 2015-02-18 | Irm Llc | Compostos e composições como inibidores de quinases |
KR20120107538A (ko) | 2007-08-22 | 2012-10-02 | 아이알엠 엘엘씨 | 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물 |
US8067422B2 (en) | 2008-03-04 | 2011-11-29 | Natco Pharma Limited | Crystal form of phenylamino pyrimidine derivatives |
JP2011513380A (ja) * | 2008-03-04 | 2011-04-28 | ナトコ ファーマ リミテッド | フェニルアミノピリミジン誘導体の結晶型 |
WO2012004801A1 (en) * | 2010-07-07 | 2012-01-12 | Hetero Research Foundation | Process for imatinib mesylate |
GB2488788B (en) * | 2011-03-07 | 2013-07-10 | Natco Pharma Ltd | Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response |
EP2751104B1 (en) | 2011-09-01 | 2019-09-25 | Novartis AG | Compounds and compositions as c-kit kinase inhibitors |
US9061028B2 (en) | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
EP2861589B1 (en) * | 2012-06-15 | 2017-05-17 | Basf Se | Multicomponent crystals comprising dasatinib and selected cocrystal formers |
UA122592C2 (uk) | 2015-12-18 | 2020-12-10 | Натко Фарма Лтд | Фармацевтичні композиції, які містять похідні феніламінопіримідину |
WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
EP4181921A1 (en) | 2020-07-15 | 2023-05-24 | Third Harmonic Bio, Inc. | Crystalline forms of a selective c-kit kinase inhibitor |
US11744823B2 (en) | 2020-11-19 | 2023-09-05 | Third Harmonic Bio, Inc. | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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TW225528B (el) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
DE69429078T2 (de) | 1993-10-01 | 2002-07-11 | Novartis Ag | Pharmacologisch wirksame pyridinderivate und verfahren zu deren herstellung |
JP3588116B2 (ja) | 1993-10-01 | 2004-11-10 | ノバルティス アクチェンゲゼルシャフト | 薬理活性のピリミジンアミン誘導体およびその製造方法 |
CA2148931A1 (en) | 1993-10-01 | 1995-04-13 | Jurg Zimmermann | Pyrimidineamine derivatives and processes for the preparation thereof |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
CN1271279A (zh) * | 1997-09-23 | 2000-10-25 | 普尼卡有限公司 | 用于治疗细胞因子介导性疾病的酰胺类衍生物 |
RU2216541C2 (ru) * | 1998-08-04 | 2003-11-20 | Астразенека Аб | Производные бензамида, способ их получения и фармацевтическая композиция на их основе |
GB0022438D0 (en) | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
CA2490907C (en) * | 2002-06-28 | 2010-08-24 | Nippon Shinyaku Co., Ltd. | Amide derivative |
GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
AU2003242988A1 (en) * | 2003-06-06 | 2005-01-04 | Adibhatla Kali Sathya Bhujanga Rao | Process for the preparation of the anti-cancer drug imatinib and its analogues |
CA2529090A1 (en) * | 2003-06-13 | 2004-12-23 | Novartis Ag | 2-aminopyrimidine derivatives as raf kinase inhibitors |
MX2007002819A (es) | 2004-09-09 | 2007-08-14 | Natco Pharma Ltd | Nuevos derivados de fenilaminopirimidina como inhibidores de bcl-abl cinasa. |
BRPI0718677A2 (pt) * | 2006-11-03 | 2013-11-26 | Irm Llc | Compostos e composições como inibidores de quinases proteicas |
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2005
- 2005-07-19 MX MX2007002819A patent/MX2007002819A/es active IP Right Grant
- 2005-07-19 DK DK05779775.5T patent/DK1786799T3/da active
- 2005-07-19 AU AU2005281299A patent/AU2005281299B2/en not_active Ceased
- 2005-07-19 EP EP05779775A patent/EP1786799B1/en active Active
- 2005-07-19 UA UAA200703971A patent/UA94570C2/ru unknown
- 2005-07-19 NZ NZ554361A patent/NZ554361A/en not_active IP Right Cessation
- 2005-07-19 JP JP2007530854A patent/JP5184887B2/ja not_active Expired - Fee Related
- 2005-07-19 PL PL05779775T patent/PL1786799T3/pl unknown
- 2005-07-19 ES ES05779775T patent/ES2390227T3/es active Active
- 2005-07-19 CN CN2005800300912A patent/CN101068805B/zh not_active Expired - Fee Related
- 2005-07-19 EA EA200700601A patent/EA013328B1/ru unknown
- 2005-07-19 CA CA2591321A patent/CA2591321C/en not_active Expired - Fee Related
- 2005-07-19 WO PCT/IN2005/000243 patent/WO2006027795A1/en active Application Filing
- 2005-07-19 AP AP2007003944A patent/AP2470A/xx active
- 2005-07-19 BR BRPI0515081A patent/BRPI0515081B8/pt not_active IP Right Cessation
- 2005-07-19 EP EP10184904.0A patent/EP2295424B1/en not_active Not-in-force
- 2005-07-19 SI SI200531589T patent/SI1786799T1/sl unknown
- 2005-07-19 PT PT05779775T patent/PT1786799E/pt unknown
- 2005-07-19 KR KR1020077008040A patent/KR100948453B1/ko active IP Right Grant
-
2007
- 2007-03-05 US US11/714,565 patent/US7910598B2/en not_active Expired - Fee Related
- 2007-03-06 ZA ZA200701942A patent/ZA200701942B/xx unknown
- 2007-03-08 IL IL181811A patent/IL181811A/en active IP Right Grant
- 2007-03-22 NO NO20071521A patent/NO337598B1/no not_active IP Right Cessation
- 2007-04-06 HR HRP20070146AA patent/HRP20070146B1/hr not_active IP Right Cessation
- 2007-04-06 MA MA29808A patent/MA28922B1/fr unknown
- 2007-04-12 ZA ZA200703123A patent/ZA200703123B/en unknown
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2008
- 2008-03-04 US US12/042,235 patent/US8183253B2/en active Active
- 2008-05-05 HK HK08104969.1A patent/HK1110588A1/xx not_active IP Right Cessation
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2012
- 2012-09-28 CY CY20121100895T patent/CY1113617T1/el unknown
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