MA28922B1 - Nouveaux derives de phenylaminopyrimidine en tant qu'inhibiteurs de bcr-abl kinase - Google Patents
Nouveaux derives de phenylaminopyrimidine en tant qu'inhibiteurs de bcr-abl kinaseInfo
- Publication number
- MA28922B1 MA28922B1 MA29808A MA29808A MA28922B1 MA 28922 B1 MA28922 B1 MA 28922B1 MA 29808 A MA29808 A MA 29808A MA 29808 A MA29808 A MA 29808A MA 28922 B1 MA28922 B1 MA 28922B1
- Authority
- MA
- Morocco
- Prior art keywords
- bcr
- kinase inhibitors
- abl kinase
- phenylaminopyrimidine derivatives
- novel phenylaminopyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN908CH2004 | 2004-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28922B1 true MA28922B1 (fr) | 2007-10-01 |
Family
ID=35395645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA29808A MA28922B1 (fr) | 2004-09-09 | 2007-04-06 | Nouveaux derives de phenylaminopyrimidine en tant qu'inhibiteurs de bcr-abl kinase |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7910598B2 (fr) |
| EP (2) | EP1786799B1 (fr) |
| JP (1) | JP5184887B2 (fr) |
| KR (1) | KR100948453B1 (fr) |
| CN (1) | CN101068805B (fr) |
| AP (1) | AP2470A (fr) |
| AU (1) | AU2005281299B2 (fr) |
| BR (1) | BRPI0515081B8 (fr) |
| CA (1) | CA2591321C (fr) |
| CY (1) | CY1113617T1 (fr) |
| DK (1) | DK1786799T3 (fr) |
| EA (1) | EA013328B1 (fr) |
| ES (1) | ES2390227T3 (fr) |
| HK (1) | HK1110588A1 (fr) |
| HR (1) | HRP20070146B1 (fr) |
| IL (1) | IL181811A (fr) |
| MA (1) | MA28922B1 (fr) |
| MX (1) | MX2007002819A (fr) |
| NO (1) | NO337598B1 (fr) |
| NZ (1) | NZ554361A (fr) |
| PL (1) | PL1786799T3 (fr) |
| PT (1) | PT1786799E (fr) |
| SI (1) | SI1786799T1 (fr) |
| UA (1) | UA94570C2 (fr) |
| WO (1) | WO2006027795A1 (fr) |
| ZA (2) | ZA200701942B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| CA2566609C (fr) | 2004-05-13 | 2012-06-26 | Icos Corporation | Quinazolinones utilisees en tant qu'inhibiteurs de la phosphatidylinositol 3-kinase delta humaine |
| US8735415B2 (en) | 2004-09-09 | 2014-05-27 | Natco Pharma Limited | Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| US20110190328A1 (en) * | 2004-09-09 | 2011-08-04 | Natco Pharma Limited | Acid addition salts of (3,5-bis trifluoromethyl)-n-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| CA2591321C (fr) | 2004-09-09 | 2013-09-24 | Natco Pharma Limited | Derives de phenylaminopyrimidine comme inhibiteurs de la kinase bcr-abl |
| US7939541B2 (en) * | 2004-09-09 | 2011-05-10 | Natco Pharma Limited | Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| WO2008031534A1 (fr) * | 2006-09-11 | 2008-03-20 | Syngenta Participations Ag | Composés insecticides |
| EP2079729A1 (fr) * | 2006-11-03 | 2009-07-22 | Irm Llc | Composés et compositions en tant qu'inhibiteurs des protéines kinases |
| CL2007003609A1 (es) * | 2006-12-14 | 2008-07-25 | Bayer Schering Pharma Ag | Compuestos derivados de dihidropiridinas sustituidas; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; proceso para producir la composicion farmaceutica; y uso en el tratamiento de una enfermedad mejorada con la inhibicion |
| BRPI0811516A2 (pt) * | 2007-05-04 | 2014-11-18 | Irm Llc | Compostos e composições como inibidores de c-kit e pdgfr cinase |
| BRPI0811617A2 (pt) * | 2007-05-04 | 2017-06-06 | Irm Llc | derivados de primidina e composições como inibidores de c-kit e pdgfr quinase. |
| PL2190825T3 (pl) | 2007-08-22 | 2014-09-30 | Novartis Ag | Związki 5-(4-(chlorowcoalkoksy)-fenylo)-pirymidyno-2-aminowe i kompozycje jako inhibitory kinazy |
| ES2368876T3 (es) | 2007-08-22 | 2011-11-23 | Irm Llc | Derivados de 2-heteroarilaminopirimidina como inhibidores de cinasa. |
| US8067422B2 (en) | 2008-03-04 | 2011-11-29 | Natco Pharma Limited | Crystal form of phenylamino pyrimidine derivatives |
| JP2011513380A (ja) * | 2008-03-04 | 2011-04-28 | ナトコ ファーマ リミテッド | フェニルアミノピリミジン誘導体の結晶型 |
| WO2012004801A1 (fr) * | 2010-07-07 | 2012-01-12 | Hetero Research Foundation | Procédé de préparation de mésylate d'imatinib |
| GB2488788B (en) * | 2011-03-07 | 2013-07-10 | Natco Pharma Ltd | Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response |
| AU2012302042B2 (en) | 2011-09-01 | 2016-03-31 | Novartis Ag | Compounds and compositions as c-kit kinase inhibitors |
| US9061028B2 (en) | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
| KR20150020683A (ko) * | 2012-06-15 | 2015-02-26 | 바스프 에스이 | 다사티닙 및 선택된 공-결정 형성제를 포함하는 다성분 결정 |
| EA036513B1 (ru) | 2015-12-18 | 2020-11-18 | Натко Фарма Лтд | Фармацевтические композиции, содержащие фениламинопиримидиновое производное |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| US11767319B2 (en) | 2020-07-15 | 2023-09-26 | Third Harmonic Bio, Inc. | Crystalline forms of a selective c-kit kinase inhibitor |
| EP4247368A1 (fr) | 2020-11-19 | 2023-09-27 | Third Harmonic Bio, Inc. | Compositions pharmaceutiques d'un inhibiteur sélectif de la kinase c-kit et leurs procédés de fabrication et d'utilisation |
| CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (fr) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| JP3588116B2 (ja) | 1993-10-01 | 2004-11-10 | ノバルティス アクチェンゲゼルシャフト | 薬理活性のピリミジンアミン誘導体およびその製造方法 |
| KR100330553B1 (ko) | 1993-10-01 | 2002-11-27 | 노파르티스 아게 | 약물학적활성피리딘유도체및그의제조방법 |
| EP0672035A1 (fr) | 1993-10-01 | 1995-09-20 | Novartis AG | Derives pyrimidineamine et leurs procedes de preparation |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| EP1017378B1 (fr) * | 1997-09-23 | 2002-12-11 | AstraZeneca AB | Derives diamide pour le traitement de maladies induites par les cytokines |
| HUP0103019A3 (en) * | 1998-08-04 | 2002-01-28 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines, process for producing them and pharmaceutical compositions containing them |
| GB0022438D0 (en) | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
| WO2004002963A1 (fr) * | 2002-06-28 | 2004-01-08 | Nippon Shinyaku Co., Ltd. | Derive d'amide |
| GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| WO2004108699A1 (fr) * | 2003-06-06 | 2004-12-16 | Natco Pharma Limited | Nouveau procede de preparation du medicament anticancereux imatinibe et de nouveaux analogues de ce medicament |
| MXPA05013349A (es) | 2003-06-13 | 2006-03-09 | Novartis Ag | Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. |
| CA2591321C (fr) | 2004-09-09 | 2013-09-24 | Natco Pharma Limited | Derives de phenylaminopyrimidine comme inhibiteurs de la kinase bcr-abl |
| EP2079729A1 (fr) * | 2006-11-03 | 2009-07-22 | Irm Llc | Composés et compositions en tant qu'inhibiteurs des protéines kinases |
-
2005
- 2005-07-19 CA CA2591321A patent/CA2591321C/fr not_active Expired - Fee Related
- 2005-07-19 NZ NZ554361A patent/NZ554361A/en not_active IP Right Cessation
- 2005-07-19 EP EP05779775A patent/EP1786799B1/fr active Active
- 2005-07-19 BR BRPI0515081A patent/BRPI0515081B8/pt not_active IP Right Cessation
- 2005-07-19 PL PL05779775T patent/PL1786799T3/pl unknown
- 2005-07-19 SI SI200531589T patent/SI1786799T1/sl unknown
- 2005-07-19 AP AP2007003944A patent/AP2470A/xx active
- 2005-07-19 JP JP2007530854A patent/JP5184887B2/ja not_active Expired - Fee Related
- 2005-07-19 CN CN2005800300912A patent/CN101068805B/zh not_active Expired - Fee Related
- 2005-07-19 PT PT05779775T patent/PT1786799E/pt unknown
- 2005-07-19 AU AU2005281299A patent/AU2005281299B2/en not_active Ceased
- 2005-07-19 KR KR1020077008040A patent/KR100948453B1/ko active IP Right Grant
- 2005-07-19 WO PCT/IN2005/000243 patent/WO2006027795A1/fr active Application Filing
- 2005-07-19 DK DK05779775.5T patent/DK1786799T3/da active
- 2005-07-19 MX MX2007002819A patent/MX2007002819A/es active IP Right Grant
- 2005-07-19 UA UAA200703971A patent/UA94570C2/ru unknown
- 2005-07-19 EA EA200700601A patent/EA013328B1/ru unknown
- 2005-07-19 EP EP10184904.0A patent/EP2295424B1/fr not_active Not-in-force
- 2005-07-19 ES ES05779775T patent/ES2390227T3/es active Active
-
2007
- 2007-03-05 US US11/714,565 patent/US7910598B2/en not_active Expired - Fee Related
- 2007-03-06 ZA ZA200701942A patent/ZA200701942B/xx unknown
- 2007-03-08 IL IL181811A patent/IL181811A/en active IP Right Grant
- 2007-03-22 NO NO20071521A patent/NO337598B1/no not_active IP Right Cessation
- 2007-04-06 HR HRP20070146AA patent/HRP20070146B1/hr not_active IP Right Cessation
- 2007-04-06 MA MA29808A patent/MA28922B1/fr unknown
- 2007-04-12 ZA ZA200703123A patent/ZA200703123B/en unknown
-
2008
- 2008-03-04 US US12/042,235 patent/US8183253B2/en active Active
- 2008-05-05 HK HK08104969.1A patent/HK1110588A1/xx not_active IP Right Cessation
-
2012
- 2012-09-28 CY CY20121100895T patent/CY1113617T1/el unknown
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