CY1109491T1 - Συζυγη μακρολιδων με αντιφλεγμονωδη δραση - Google Patents
Συζυγη μακρολιδων με αντιφλεγμονωδη δρασηInfo
- Publication number
- CY1109491T1 CY1109491T1 CY20091101070T CY091101070T CY1109491T1 CY 1109491 T1 CY1109491 T1 CY 1109491T1 CY 20091101070 T CY20091101070 T CY 20091101070T CY 091101070 T CY091101070 T CY 091101070T CY 1109491 T1 CY1109491 T1 CY 1109491T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formula
- inflammatory action
- macrolides
- consumption
- steroids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Abstract
Η παρούσα εφεύρεση αναφέρεται σε νέες ενώσεις παριστώμενες από τον Τύπο (I), στον οποίο το Μ παριστά μία υπομονάδα μακρολίδης με υποδομή II, Τύπου (II)· το L παριστά την άλυσο με την υποδομή III, Τύπου (III)· το D παριστά τη στεροειδή ή μη στεροειδή υπομονάδα που προέρχεται από στεροειδή ή μη στεροειδή (NSAID) φάρμακα με αντιφλεγμονώδη δράση. Η παρούσα εφεύρεση αναφέρεται επίσης σε φαρμακευτικά αποδεκτά άλατα και στερεά διαλύματα αυτών των παρασκευαζόμενων ενώσεων, σε μεθόδους και ενδιάμεσα για την παρασκευή τους, καθώς και στη βελτιωμένη θεραπευτική δράση και στη χρήση στην αγωγή φλεγμονωδών νόσων και καταστάσεων σε ανθρώπους και ζώα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20030324A HRP20030324A2 (en) | 2003-04-24 | 2003-04-24 | Compounds of antiinflammatory effect |
EP04729157A EP1633771B1 (en) | 2003-04-24 | 2004-04-23 | Macrolide-conjugates with anti-inflammatory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109491T1 true CY1109491T1 (el) | 2014-08-13 |
Family
ID=33307078
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091101070T CY1109491T1 (el) | 2003-04-24 | 2009-10-14 | Συζυγη μακρολιδων με αντιφλεγμονωδη δραση |
CY20111101008T CY1111978T1 (el) | 2003-04-24 | 2011-10-25 | Συζυγη μακρολιδων με αντιφλεγμονωδη δραση |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111101008T CY1111978T1 (el) | 2003-04-24 | 2011-10-25 | Συζυγη μακρολιδων με αντιφλεγμονωδη δραση |
Country Status (28)
Country | Link |
---|---|
US (1) | US7579334B2 (el) |
EP (2) | EP2070940B1 (el) |
JP (1) | JP4613366B2 (el) |
KR (1) | KR101107336B1 (el) |
CN (1) | CN100393741C (el) |
AR (1) | AR044083A1 (el) |
AT (1) | ATE518876T1 (el) |
AU (1) | AU2004232546B2 (el) |
BR (1) | BRPI0410490A (el) |
CA (1) | CA2523081C (el) |
CL (1) | CL2004000872A1 (el) |
CY (2) | CY1109491T1 (el) |
DE (1) | DE602004022047D1 (el) |
DK (2) | DK1633771T3 (el) |
ES (2) | ES2330109T3 (el) |
HK (2) | HK1086842A1 (el) |
HR (3) | HRP20030324A2 (el) |
IS (2) | IS2736B (el) |
ME (1) | MEP34708A (el) |
MX (1) | MXPA05011359A (el) |
NO (2) | NO333909B1 (el) |
PL (2) | PL2070940T3 (el) |
PT (2) | PT1633771E (el) |
RS (1) | RS52621B (el) |
RU (1) | RU2355699C2 (el) |
SI (2) | SI1633771T1 (el) |
WO (1) | WO2004094449A1 (el) |
ZA (1) | ZA200508388B (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
BRPI0514254A (pt) * | 2004-08-12 | 2008-06-03 | Glaxosmithkline Zagreb | uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinal |
US20060183696A1 (en) * | 2004-08-12 | 2006-08-17 | Pliva-Istrazivacki Institut D.O.O. | Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract |
ES2337915T3 (es) | 2004-10-27 | 2010-04-30 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Conjugados con adtividad antiinflamatoria. |
TWI423819B (zh) * | 2005-12-22 | 2014-01-21 | Hydra Biosciences Inc | 用於調節trpa1功能之化合物 |
WO2007093840A2 (en) * | 2006-02-15 | 2007-08-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
EP2262483A2 (en) * | 2008-03-05 | 2010-12-22 | Panacea Biotec Limited | Modified release pharmaceutical compositions comprising mycophenolate and processes thereof |
CN102838660B (zh) * | 2011-06-23 | 2016-11-02 | 上海市第一人民医院 | 一种抑制炎症免疫反应的小肽及其应用 |
US20140256696A1 (en) | 2013-03-08 | 2014-09-11 | Allergan, Inc. | Steroid conjugates |
WO2014138343A1 (en) * | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Antibiotic conjugates with nonsteroidal anti-inflammatory drugs |
BR112015021836A2 (pt) | 2013-03-08 | 2017-07-18 | Allergan Inc | conjugados de antibióticos diretamente ligados com drogas esteroides |
JP2016510753A (ja) * | 2013-03-08 | 2016-04-11 | アラーガン、インコーポレイテッドAllergan,Incorporated | ステロイド薬と結合した抗生物質共役体 |
WO2016013030A2 (en) | 2014-07-23 | 2016-01-28 | Sphaera Pharma Pvt. Ltd. | Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257956B2 (en) | 1986-08-19 | 2000-11-22 | Genentech, Inc. | Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion |
DE3860503D1 (de) * | 1987-09-03 | 1990-10-04 | Pliva Pharm & Chem Works | 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung. |
SE9100341D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
SE9100342D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroid esters |
GB9225923D0 (en) | 1992-12-11 | 1993-02-03 | Rhone Poulenc Rorer Ltd | New compositions of matter |
CA2149777C (en) | 1992-12-24 | 2004-05-25 | Michael John Ashton | New steroids |
KR970704455A (ko) | 1994-08-12 | 1997-09-06 | 우에하라 아끼라 | 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor) |
WO1996004920A1 (fr) | 1994-08-12 | 1996-02-22 | Taisho Pharmaceutical Co., Ltd. | Inhibiteur de production de l'interleukine-5 |
DE19616573C2 (de) | 1996-04-25 | 1999-03-04 | Pari Gmbh | Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase |
JP3530004B2 (ja) | 1998-02-06 | 2004-05-24 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
WO2000025776A1 (en) * | 1998-10-30 | 2000-05-11 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
IT1306205B1 (it) | 1999-01-15 | 2001-05-30 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
HRP20000310A2 (en) | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
FI110835B (fi) | 2000-07-11 | 2003-03-31 | Radiolinja Ab | Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla |
HRP20010018A2 (en) | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
US20040186063A1 (en) * | 2002-02-15 | 2004-09-23 | Hans-Jurgen Gutke | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
US20050171342A1 (en) * | 2002-02-15 | 2005-08-04 | Michael Burnet | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
EP1483579A4 (en) * | 2002-02-15 | 2006-07-12 | Merckle Gmbh | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES |
EP1551865B1 (en) * | 2002-07-08 | 2009-04-22 | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. | Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules |
PL374646A1 (en) | 2002-07-08 | 2005-10-31 | Pliva-Istrazivacki Institutt D.O.O. | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
CA2489402A1 (en) * | 2002-07-08 | 2004-01-15 | Pliva-Istrazivacki Institut D.O.O. | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
-
2003
- 2003-04-24 HR HR20030324A patent/HRP20030324A2/hr not_active Application Discontinuation
-
2004
- 2004-04-22 US US10/830,858 patent/US7579334B2/en not_active Expired - Fee Related
- 2004-04-23 PL PL09075145T patent/PL2070940T3/pl unknown
- 2004-04-23 AU AU2004232546A patent/AU2004232546B2/en not_active Ceased
- 2004-04-23 CN CNB2004800110487A patent/CN100393741C/zh not_active Expired - Fee Related
- 2004-04-23 CL CL200400872A patent/CL2004000872A1/es unknown
- 2004-04-23 DK DK04729157T patent/DK1633771T3/da active
- 2004-04-23 WO PCT/IB2004/001235 patent/WO2004094449A1/en active Application Filing
- 2004-04-23 PL PL04729157T patent/PL1633771T3/pl unknown
- 2004-04-23 MX MXPA05011359A patent/MXPA05011359A/es active IP Right Grant
- 2004-04-23 RS YU20050873A patent/RS52621B/en unknown
- 2004-04-23 RU RU2005131937/04A patent/RU2355699C2/ru not_active IP Right Cessation
- 2004-04-23 PT PT04729157T patent/PT1633771E/pt unknown
- 2004-04-23 CA CA2523081A patent/CA2523081C/en not_active Expired - Lifetime
- 2004-04-23 SI SI200431253T patent/SI1633771T1/sl unknown
- 2004-04-23 KR KR1020057020252A patent/KR101107336B1/ko not_active IP Right Cessation
- 2004-04-23 PT PT09075145T patent/PT2070940E/pt unknown
- 2004-04-23 ES ES04729157T patent/ES2330109T3/es not_active Expired - Lifetime
- 2004-04-23 SI SI200431768T patent/SI2070940T1/sl unknown
- 2004-04-23 AT AT09075145T patent/ATE518876T1/de active
- 2004-04-23 DK DK09075145.4T patent/DK2070940T3/da active
- 2004-04-23 AR ARP040101400A patent/AR044083A1/es unknown
- 2004-04-23 ME MEP-347/08A patent/MEP34708A/xx unknown
- 2004-04-23 BR BRPI0410490-0A patent/BRPI0410490A/pt not_active Application Discontinuation
- 2004-04-23 EP EP09075145A patent/EP2070940B1/en not_active Expired - Lifetime
- 2004-04-23 EP EP04729157A patent/EP1633771B1/en not_active Expired - Lifetime
- 2004-04-23 ES ES09075145T patent/ES2370371T3/es not_active Expired - Lifetime
- 2004-04-23 DE DE602004022047T patent/DE602004022047D1/de not_active Expired - Lifetime
- 2004-04-23 JP JP2006506511A patent/JP4613366B2/ja not_active Expired - Fee Related
-
2005
- 2005-10-17 ZA ZA200508388A patent/ZA200508388B/xx unknown
- 2005-11-22 IS IS8141A patent/IS2736B/is unknown
- 2005-11-23 NO NO20055535A patent/NO333909B1/no not_active IP Right Cessation
-
2006
- 2006-08-09 HK HK06108841.8A patent/HK1086842A1/xx not_active IP Right Cessation
-
2009
- 2009-07-24 HK HK09106861.4A patent/HK1129681A1/xx not_active IP Right Cessation
- 2009-10-14 CY CY20091101070T patent/CY1109491T1/el unknown
- 2009-10-15 HR HR20090551T patent/HRP20090551T1/hr unknown
-
2010
- 2010-12-29 IS IS8941A patent/IS8941A/is unknown
-
2011
- 2011-10-19 HR HR20110763T patent/HRP20110763T1/hr unknown
- 2011-10-25 CY CY20111101008T patent/CY1111978T1/el unknown
-
2013
- 2013-06-28 NO NO20130898A patent/NO335552B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1109491T1 (el) | Συζυγη μακρολιδων με αντιφλεγμονωδη δραση | |
CY1121350T1 (el) | Απο του στοματος φαρμακοτεχνικες μορφες αναλογων κυτιδινης και μεθοδοι χρησης αυτων | |
CY1117085T1 (el) | C7-φθορο υποκατεστημενες ενωσεις τετρακυκλινης | |
CY1118016T1 (el) | ΑΝΑΣΤΟΛΕΙΣ Ν1-ΠΥΡΑΖΟΛΟΣΠΕΙΡΟΚΕΤΟΝΗΣ ΑΚΕΤΥΛ-CoA ΚΑΡΒΟΞΥΛΑΣΗΣ | |
CY1112369T1 (el) | 2-μεθυλο-2-[4-(3-μεθυλο-2-οξο-8-κινολιν-3-υλο-2,3-διϋδρο-ιμιδαζο[4,5-c]κινολινυλο)-φαινυλο]προπιονιτριλιο ως αναστολεας λιπιδικης κινασης | |
CY1120080T1 (el) | Φαρμακευτικη συνθεση περιεχουσα εναν αναστολεα hdac και εναν κυκλοπολυσακχαριτη | |
CY1115738T1 (el) | Κρυσταλλικα επιδιαλυτωμενα συμπλοκα των παραγωγων (1s)-1,5-anyδpo-1-c-(3-((φainyλ)meθυλ) φαινυλ)-d-γλουσιτολης με αλκοολες οπως αναστολεις sglt2 για τη θεραπευτικη αντιμετωπιση του διαβητη | |
CY1117122T1 (el) | Παραγωγα πυραζολοσπειροκετονης για χρηση ως αναστολεις ακετyλ-coa καρβοξυλασης | |
CY1114478T1 (el) | Παραγωγα πυριδαζινης ως αναστολεις smo | |
EA200601686A1 (ru) | Замещенные производные морфолина и тиоморфолина | |
CY1122182T1 (el) | Ανοσοκατασταλτικες φαρμακοτεχνικες μορφες | |
CY1111830T1 (el) | Παραγωγα πυριδινης ως ρυθμιστες υποδοχεων s1p1/edg1 | |
NO20050571L (no) | Nye ikke steroide anti-inflammatoriske substanser, sammensetninger og metoder for deres anvendelse | |
CY1120403T1 (el) | Ανταγωνιστες trpm8 | |
CY1118947T1 (el) | Ασυμμετρες ουριες και ιατρικες χρησεις αυτων | |
MX2007005073A (es) | Conjugados con actividad antiinflamtoria. | |
CY1117503T1 (el) | Αζωτουχος αρωματικη ετεροκυκλυλο ενωση | |
EA200901423A1 (ru) | Бензимидазолы и содержащие их фармацевтические композиции | |
EA201170722A1 (ru) | Лактамы в качестве ингибиторов бета-секретазы | |
CY1118583T1 (el) | Σταθερες δοσολογικες μορφες ανθελονοσιακων σπιρο και δισπιρο 1,2,4-τριοξολανιων | |
CY1112366T1 (el) | Ενωσεις βενζιμιδαζολης- καρβοξαμιδης ως αγωνιστες του 5-ητ4 υποδοχεα | |
CY1113504T1 (el) | Παραγωγο προπανο-1,3-διονης ή αλας αυτου | |
CY1113197T1 (el) | Παραγωγα 5-υδροξυμεθυλ- οξαζολιδιν-2-ονης για την αντιμετωπιση βακτηριακων νοσων του εντερου | |
CY1119786T1 (el) | Φαρμακευτικη συνθεση που περιλαμβανει (1r-4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη | |
CY1108584T1 (el) | Παραγωγα 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline ως φαρμακα για τη θεραπεια της στειροτητας |