BRPI0514254A - uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinal - Google Patents
uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinalInfo
- Publication number
- BRPI0514254A BRPI0514254A BRPI0514254-7A BRPI0514254A BRPI0514254A BR PI0514254 A BRPI0514254 A BR PI0514254A BR PI0514254 A BRPI0514254 A BR PI0514254A BR PI0514254 A BRPI0514254 A BR PI0514254A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- inflammatory diseases
- cell
- gastrointestinal tract
- specific conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Abstract
USO DE CONJUGADOS CéLULA-ESPECìFICOS PARA O TRATAMENTO DE DOENçAS INFLAMATóRIAS DO TRATO GASTRINTESTINAL. A presente invenção está direcionada a métodos para a prevenção e tratamento de doenças, distúrbios, e condições inflamatórias do trato gastrintestinal mediante administrar a um paciente com necessidade de tal tratamento compostos conjugados de acordo com a fórmula (VII) possuindo baixa biodisponibilidade oral, ou seus sais, pró-drogas, ou solvatos farmaceuticamente aceitáveis: onde M representa uma subunidade macrolida que possui a propriedade de acumulação nas células inflamatórias, T representa uma subunidade antiinflamatória que pode ser um esteróide ou um não esteróide (fração não-esteroidal) derivada de uma droga não esteroidal com atividade antiinflamatória, analgésica e/ou antipirética (NSAID) e L representa um ligante que liga de modo covalente M e T. A presente revelação está também direcionada a composições farmacêuticas contendo compostos conjugados de fórmula (VII) possuindo baixa biodisponibilidade oral.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60108704P | 2004-08-12 | 2004-08-12 | |
US60331504P | 2004-08-19 | 2004-08-19 | |
PCT/IB2005/002406 WO2006018698A2 (en) | 2004-08-12 | 2005-08-10 | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0514254A true BRPI0514254A (pt) | 2008-06-03 |
Family
ID=35602235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0514254-7A BRPI0514254A (pt) | 2004-08-12 | 2005-08-10 | uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinal |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060035845A1 (pt) |
EP (1) | EP1778292A2 (pt) |
JP (1) | JP2008509899A (pt) |
KR (1) | KR20070046917A (pt) |
AU (1) | AU2005273592A1 (pt) |
BR (1) | BRPI0514254A (pt) |
CA (1) | CA2576291A1 (pt) |
IL (1) | IL181240A0 (pt) |
MA (1) | MA28809B1 (pt) |
MX (1) | MX2007001669A (pt) |
NO (1) | NO20071244L (pt) |
RU (1) | RU2007108544A (pt) |
WO (1) | WO2006018698A2 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8282678B2 (en) | 2002-11-13 | 2012-10-09 | Allium Medical Solutions Ltd. | Endoluminal lining |
JP2008517993A (ja) * | 2004-10-27 | 2008-05-29 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 抗炎症作用を有するコンジュゲート |
US8133268B2 (en) | 2007-05-30 | 2012-03-13 | Cordis Corporation | Stent/fiber structural combinations |
WO2010045180A1 (en) | 2008-10-13 | 2010-04-22 | Metabolon, Inc. | Biomarkers for inflammatory bowel disease and methods using the same |
JP5945868B2 (ja) * | 2010-05-25 | 2016-07-13 | センヤン トンリァン グループ カンパニー,リミテッド | レボイソバレリルスピラマイシンi、ii又はiiiとその製剤、調製方法及び応用 |
EP2578596B1 (en) * | 2010-05-25 | 2017-04-19 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Levocarrimycin, pharmaceutical compositions, preparation methods and uses thereof |
GB201304662D0 (en) * | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
JPH07103148B2 (ja) * | 1991-12-16 | 1995-11-08 | 株式会社ディ・ディ・エス研究所 | アントラサイクリン−マクロライド複合体 |
HRP20010018A2 (en) * | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
US20030105144A1 (en) * | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
AU2003215245A1 (en) * | 2002-02-15 | 2003-09-09 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
US20040186063A1 (en) * | 2002-02-15 | 2004-09-23 | Hans-Jurgen Gutke | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
AU2003211113B2 (en) * | 2002-02-15 | 2007-08-09 | Merckle Gmbh | Antibiotic conjugates |
NZ535354A (en) * | 2002-02-15 | 2008-01-31 | Merckle Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
ES2325495T3 (es) * | 2002-07-08 | 2009-09-07 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas. |
CA2489398A1 (en) * | 2002-07-08 | 2004-01-15 | Pliva-Istrazivacki Institut D.O.O. | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
RU2330858C2 (ru) * | 2002-07-08 | 2008-08-10 | Глаксомитклайн Истраживацки Центар Загреб Д.О.О. | Новые соединения, составы и способы лечения воспалительных заболеваний и состояний |
HRP20030324A2 (en) * | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
-
2005
- 2005-08-10 WO PCT/IB2005/002406 patent/WO2006018698A2/en active Application Filing
- 2005-08-10 AU AU2005273592A patent/AU2005273592A1/en not_active Abandoned
- 2005-08-10 JP JP2007525378A patent/JP2008509899A/ja active Pending
- 2005-08-10 KR KR1020077005633A patent/KR20070046917A/ko not_active Application Discontinuation
- 2005-08-10 MX MX2007001669A patent/MX2007001669A/es not_active Application Discontinuation
- 2005-08-10 CA CA002576291A patent/CA2576291A1/en not_active Abandoned
- 2005-08-10 US US11/201,685 patent/US20060035845A1/en not_active Abandoned
- 2005-08-10 RU RU2007108544/14A patent/RU2007108544A/ru not_active Application Discontinuation
- 2005-08-10 BR BRPI0514254-7A patent/BRPI0514254A/pt not_active Application Discontinuation
- 2005-08-10 EP EP05786822A patent/EP1778292A2/en not_active Withdrawn
-
2007
- 2007-02-08 IL IL181240A patent/IL181240A0/en unknown
- 2007-02-21 MA MA29693A patent/MA28809B1/fr unknown
- 2007-03-07 NO NO20071244A patent/NO20071244L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20071244L (no) | 2007-04-17 |
MX2007001669A (es) | 2007-04-10 |
EP1778292A2 (en) | 2007-05-02 |
IL181240A0 (en) | 2007-07-04 |
JP2008509899A (ja) | 2008-04-03 |
RU2007108544A (ru) | 2008-09-20 |
AU2005273592A1 (en) | 2006-02-23 |
KR20070046917A (ko) | 2007-05-03 |
US20060035845A1 (en) | 2006-02-16 |
CA2576291A1 (en) | 2006-02-23 |
MA28809B1 (fr) | 2007-08-01 |
WO2006018698A3 (en) | 2006-12-28 |
WO2006018698A2 (en) | 2006-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/7048 (2006.01), A61K 31/7052 (2006.01), A6 |