PL2070940T3 - Makrolidowe koniugaty o aktywności przeciwzapalnej - Google Patents

Makrolidowe koniugaty o aktywności przeciwzapalnej

Info

Publication number
PL2070940T3
PL2070940T3 PL09075145T PL09075145T PL2070940T3 PL 2070940 T3 PL2070940 T3 PL 2070940T3 PL 09075145 T PL09075145 T PL 09075145T PL 09075145 T PL09075145 T PL 09075145T PL 2070940 T3 PL2070940 T3 PL 2070940T3
Authority
PL
Poland
Prior art keywords
macrolide
conjugates
inflammatory activity
inflammatory
activity
Prior art date
Application number
PL09075145T
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Stribor Markovic
Boska Hrvacic
Oresta Makaruha
Vionja Poljak
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PL2070940T3 publication Critical patent/PL2070940T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL09075145T 2003-04-24 2004-04-23 Makrolidowe koniugaty o aktywności przeciwzapalnej PL2070940T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR20030324A HRP20030324A2 (en) 2003-04-24 2003-04-24 Compounds of antiinflammatory effect
EP04729157A EP1633771B1 (en) 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity
EP09075145A EP2070940B1 (en) 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity

Publications (1)

Publication Number Publication Date
PL2070940T3 true PL2070940T3 (pl) 2011-12-30

Family

ID=33307078

Family Applications (2)

Application Number Title Priority Date Filing Date
PL09075145T PL2070940T3 (pl) 2003-04-24 2004-04-23 Makrolidowe koniugaty o aktywności przeciwzapalnej
PL04729157T PL1633771T3 (pl) 2003-04-24 2004-04-23 Koniugaty makrolidowe o aktywności przeciwzapalnej

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL04729157T PL1633771T3 (pl) 2003-04-24 2004-04-23 Koniugaty makrolidowe o aktywności przeciwzapalnej

Country Status (27)

Country Link
US (1) US7579334B2 (pl)
EP (2) EP1633771B1 (pl)
JP (1) JP4613366B2 (pl)
KR (1) KR101107336B1 (pl)
CN (1) CN100393741C (pl)
AR (1) AR044083A1 (pl)
AT (1) ATE518876T1 (pl)
AU (1) AU2004232546B2 (pl)
BR (1) BRPI0410490A (pl)
CA (1) CA2523081C (pl)
CL (1) CL2004000872A1 (pl)
CY (2) CY1109491T1 (pl)
DE (1) DE602004022047D1 (pl)
DK (2) DK2070940T3 (pl)
ES (2) ES2370371T3 (pl)
HR (3) HRP20030324A2 (pl)
IS (2) IS2736B (pl)
ME (1) MEP34708A (pl)
MX (1) MXPA05011359A (pl)
NO (2) NO333909B1 (pl)
PL (2) PL2070940T3 (pl)
PT (2) PT1633771E (pl)
RS (1) RS52621B (pl)
RU (1) RU2355699C2 (pl)
SI (2) SI1633771T1 (pl)
WO (1) WO2004094449A1 (pl)
ZA (1) ZA200508388B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
RU2007108544A (ru) * 2004-08-12 2008-09-20 Глаксосмитклайн Истраживацки Центар Загреб Д.О.О.(Hr) Применение клеточно-специфических конъюгатов для лечения воспалительных заболеваний желудочно-кишечного тракта
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
DE602005018672D1 (de) * 2004-10-27 2010-02-11 Glaxosmithkline Zagreb Konjugate mit entzündungshemmender aktivität
CN102499921A (zh) * 2005-12-22 2012-06-20 海德拉生物科学公司 治疗疼痛的方法和组合物
WO2007093840A2 (en) * 2006-02-15 2007-08-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
KR20100126465A (ko) * 2008-03-05 2010-12-01 파나세아 바이오테크 리미티드 미코페놀레이트를 포함하는 변형 방출 제약 조성물 및 그것의 방법
CN102838660B (zh) * 2011-06-23 2016-11-02 上海市第一人民医院 一种抑制炎症免疫反应的小肽及其应用
WO2014115167A2 (en) * 2013-01-23 2014-07-31 Sphaera Pharma Pvt. Ltd. Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
WO2014138403A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Antibiotic conjugates
RU2015138891A (ru) 2013-03-08 2017-04-11 Аллерган, Инк. Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами
JP2016510753A (ja) * 2013-03-08 2016-04-11 アラーガン、インコーポレイテッドAllergan,Incorporated ステロイド薬と結合した抗生物質共役体
EP2964265A1 (en) * 2013-03-08 2016-01-13 Allergan, Inc. Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
EP3795578A3 (en) 2014-07-23 2021-05-26 Sphaera Pharma Pvt. Ltd. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof

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ES2032831T5 (es) 1986-08-19 2001-02-16 Genentech Inc Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas.
HU198913B (en) * 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
HUT72442A (en) 1992-12-24 1996-04-29 Rhone Poulenc Rorer Ltd Steroids condensed with heteroring containing oxygene, pharmaceutical compositions containing them and processes for their production
AU3192595A (en) 1994-08-12 1996-03-07 Taisho Pharmaceutical Co., Ltd. Interleukin-5 production inhibitor
CA2196878A1 (en) 1994-08-12 1996-02-22 Akihiko Hoshino Interleukin-5 production inhibitor
DE19616573C2 (de) 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
WO2000025776A1 (en) * 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
FI110835B (fi) 2000-07-11 2003-03-31 Radiolinja Ab Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
US20040005641A1 (en) * 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003219770B2 (en) * 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
JP2005536488A (ja) * 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
JP4790263B2 (ja) * 2002-07-08 2011-10-12 グラクソ グループ リミテッド 炎症性の疾患および病態を治療する新規な化合物、組成物および方法
US7157433B2 (en) * 2002-07-08 2007-01-02 Glaxosmithkline Istrazivacki Centar Zagreb Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect

Also Published As

Publication number Publication date
NO335552B1 (no) 2014-12-29
KR101107336B1 (ko) 2012-01-19
MEP34708A (en) 2011-05-10
NO20130898L (no) 2006-01-16
CY1109491T1 (el) 2014-08-13
EP2070940A1 (en) 2009-06-17
IS8141A (is) 2005-11-22
WO2004094449A8 (en) 2005-03-31
HRP20110763T1 (hr) 2011-11-30
IS8941A (is) 2010-12-29
NO20055535L (no) 2006-01-16
IS2736B (is) 2011-06-15
AR044083A1 (es) 2005-08-24
EP2070940A3 (en) 2009-11-25
CN1777619A (zh) 2006-05-24
HRP20090551T1 (hr) 2010-01-31
CA2523081C (en) 2010-08-03
HK1086842A1 (zh) 2006-09-29
HK1129681A1 (en) 2009-12-04
EP2070940B1 (en) 2011-08-03
PT2070940E (pt) 2011-11-14
ZA200508388B (en) 2006-07-26
US20050080003A1 (en) 2005-04-14
MXPA05011359A (es) 2006-05-12
DK1633771T3 (da) 2009-11-16
RU2355699C2 (ru) 2009-05-20
HRP20030324A2 (en) 2005-02-28
RU2005131937A (ru) 2006-06-27
US7579334B2 (en) 2009-08-25
SI2070940T1 (sl) 2011-12-30
EP1633771B1 (en) 2009-07-15
NO333909B1 (no) 2013-10-14
WO2004094449A1 (en) 2004-11-04
PL1633771T3 (pl) 2009-12-31
RS52621B (sr) 2013-06-28
CL2004000872A1 (es) 2005-03-18
AU2004232546A1 (en) 2004-11-04
CN100393741C (zh) 2008-06-11
AU2004232546B2 (en) 2011-06-09
CA2523081A1 (en) 2004-11-04
BRPI0410490A (pt) 2006-06-13
NO20055535D0 (no) 2005-11-23
EP1633771A1 (en) 2006-03-15
DE602004022047D1 (de) 2009-08-27
KR20060024770A (ko) 2006-03-17
ES2370371T3 (es) 2011-12-14
CY1111978T1 (el) 2015-11-04
RS20050873A (sr) 2007-08-03
SI1633771T1 (sl) 2009-12-31
DK2070940T3 (da) 2011-10-31
JP4613366B2 (ja) 2011-01-19
PT1633771E (pt) 2009-10-20
ES2330109T3 (es) 2009-12-04
ATE518876T1 (de) 2011-08-15
JP2006524221A (ja) 2006-10-26

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