CY1108345T1 - Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου - Google Patents
Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιουInfo
- Publication number
- CY1108345T1 CY1108345T1 CY20081100998T CY081100998T CY1108345T1 CY 1108345 T1 CY1108345 T1 CY 1108345T1 CY 20081100998 T CY20081100998 T CY 20081100998T CY 081100998 T CY081100998 T CY 081100998T CY 1108345 T1 CY1108345 T1 CY 1108345T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dibenzo
- carboxamide
- dihydro
- azepino
- oxo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1h-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 abstract 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 abstract 2
- 229960000623 carbamazepine Drugs 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006735 epoxidation reaction Methods 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112812.3A GB0112812D0 (en) | 2001-05-25 | 2001-05-25 | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
| PCT/GB2002/002356 WO2002096881A1 (en) | 2001-05-25 | 2002-05-22 | Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108345T1 true CY1108345T1 (el) | 2012-01-25 |
Family
ID=9915332
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100998T CY1108345T1 (el) | 2001-05-25 | 2008-09-17 | Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου |
| CY2009017C CY2009017I1 (el) | 2001-05-25 | 2009-10-19 | Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου |
| CY20111100515T CY1111492T1 (el) | 2001-05-25 | 2011-05-27 | ΜΙΑ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ 10,11-ΔΙΥΔΡΟ-10-ΟΞΟ-5Η-ΔΙΒΕΝΖΟ[b,f]ΑΖΕΠΙΝΟ-5-ΚΑΡΒΟΞΑΜΙΔΙΟΥ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2009017C CY2009017I1 (el) | 2001-05-25 | 2009-10-19 | Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου |
| CY20111100515T CY1111492T1 (el) | 2001-05-25 | 2011-05-27 | ΜΙΑ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ 10,11-ΔΙΥΔΡΟ-10-ΟΞΟ-5Η-ΔΙΒΕΝΖΟ[b,f]ΑΖΕΠΙΝΟ-5-ΚΑΡΒΟΞΑΜΙΔΙΟΥ |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7241886B2 (https=) |
| EP (2) | EP1958938B1 (https=) |
| JP (3) | JP4323309B2 (https=) |
| KR (1) | KR100931916B1 (https=) |
| CN (2) | CN101172967A (https=) |
| AR (1) | AR035460A1 (https=) |
| AT (2) | ATE400560T1 (https=) |
| AU (2) | AU2002307863B8 (https=) |
| BR (1) | BR0210019A (https=) |
| CA (2) | CA2750876C (https=) |
| CY (3) | CY1108345T1 (https=) |
| CZ (1) | CZ303130B6 (https=) |
| DE (2) | DE60239842D1 (https=) |
| DK (2) | DK1958938T3 (https=) |
| ES (2) | ES2362688T3 (https=) |
| GB (1) | GB0112812D0 (https=) |
| HU (1) | HU230019B1 (https=) |
| LU (1) | LU91603I2 (https=) |
| MX (1) | MXPA03010793A (https=) |
| PL (1) | PL215305B1 (https=) |
| RU (2) | RU2311411C2 (https=) |
| SI (1) | SI1399424T1 (https=) |
| WO (1) | WO2002096881A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| ITMI20042230A1 (it) | 2004-11-19 | 2005-02-19 | Farchemia Srl | Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide |
| ITMI20042291A1 (it) * | 2004-11-26 | 2005-02-26 | Farchema S R L | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
| GB2422149A (en) * | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| US20060252745A1 (en) * | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| RU2012106827A (ru) | 2009-07-27 | 2013-09-10 | БИАЛ-ПОРТЕЛА энд КА., С.А. | Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии |
| US20150065704A1 (en) | 2011-07-13 | 2015-03-05 | Ketan Hirpara | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
| IN2015DN02296A (https=) | 2012-09-26 | 2015-08-21 | Ranbaxy Lab Ltd | |
| AU2016324165B2 (en) | 2015-09-16 | 2020-07-02 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective DNA sequencing |
| US12492423B2 (en) | 2015-09-16 | 2025-12-09 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective DNA sequencing |
| CN111943347B (zh) * | 2020-07-16 | 2022-08-30 | 同济大学 | 一种铜离子活化过氧乙酸去除废水中卡马西平的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439390B2 (https=) * | 1971-09-30 | 1979-11-27 | ||
| BE789320A (fr) | 1971-09-30 | 1973-03-27 | Takeda Chemical Industries Ltd | Derives de dibenzoxirenazepine |
| CH633271A5 (en) * | 1978-04-18 | 1982-11-30 | Ciba Geigy Ag | Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines |
| CH642950A5 (en) * | 1979-10-30 | 1984-05-15 | Ciba Geigy Ag | Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| IT1272897B (it) * | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| PT101876B (pt) * | 1996-05-27 | 1999-09-30 | Portela & Ca Sa | Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida |
| AT408224B (de) * | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxcarbazepin |
-
2001
- 2001-05-25 GB GBGB0112812.3A patent/GB0112812D0/en not_active Ceased
-
2002
- 2002-05-22 DK DK08075527.5T patent/DK1958938T3/da active
- 2002-05-22 WO PCT/GB2002/002356 patent/WO2002096881A1/en not_active Ceased
- 2002-05-22 KR KR1020037015323A patent/KR100931916B1/ko not_active Expired - Fee Related
- 2002-05-22 CZ CZ20033203A patent/CZ303130B6/cs not_active IP Right Cessation
- 2002-05-22 HU HU0400296A patent/HU230019B1/hu unknown
- 2002-05-22 ES ES08075527T patent/ES2362688T3/es not_active Expired - Lifetime
- 2002-05-22 EP EP08075527A patent/EP1958938B1/en not_active Expired - Lifetime
- 2002-05-22 PL PL366993A patent/PL215305B1/pl unknown
- 2002-05-22 BR BR0210019-3A patent/BR0210019A/pt active Search and Examination
- 2002-05-22 CA CA2750876A patent/CA2750876C/en not_active Expired - Fee Related
- 2002-05-22 RU RU2003137224/04A patent/RU2311411C2/ru active
- 2002-05-22 SI SI200230717T patent/SI1399424T1/sl unknown
- 2002-05-22 ES ES02774050T patent/ES2305299T3/es not_active Expired - Lifetime
- 2002-05-22 AT AT02774050T patent/ATE400560T1/de active
- 2002-05-22 CN CNA2007101939981A patent/CN101172967A/zh active Pending
- 2002-05-22 MX MXPA03010793A patent/MXPA03010793A/es active IP Right Grant
- 2002-05-22 AU AU2002307863A patent/AU2002307863B8/en not_active Ceased
- 2002-05-22 CA CA2448094A patent/CA2448094C/en not_active Expired - Lifetime
- 2002-05-22 US US10/478,770 patent/US7241886B2/en not_active Expired - Lifetime
- 2002-05-22 CN CN028105915A patent/CN1511141B/zh not_active Expired - Fee Related
- 2002-05-22 JP JP2003500061A patent/JP4323309B2/ja not_active Expired - Fee Related
- 2002-05-22 DK DK02774050T patent/DK1399424T3/da active
- 2002-05-22 DE DE60239842T patent/DE60239842D1/de not_active Expired - Lifetime
- 2002-05-22 EP EP02774050A patent/EP1399424B8/en not_active Expired - Lifetime
- 2002-05-22 DE DE60227517T patent/DE60227517D1/de not_active Expired - Lifetime
- 2002-05-22 AT AT08075527T patent/ATE506351T1/de active
- 2002-05-24 AR ARP020101958A patent/AR035460A1/es not_active Application Discontinuation
-
2007
- 2007-06-01 RU RU2007120532/04A patent/RU2449992C2/ru not_active IP Right Cessation
- 2007-10-04 AU AU2007221834A patent/AU2007221834B2/en not_active Ceased
-
2008
- 2008-08-05 JP JP2008201613A patent/JP2009057376A/ja active Pending
- 2008-09-17 CY CY20081100998T patent/CY1108345T1/el unknown
-
2009
- 2009-03-09 JP JP2009054515A patent/JP5280252B2/ja not_active Expired - Fee Related
- 2009-08-28 LU LU91603C patent/LU91603I2/fr unknown
- 2009-10-19 CY CY2009017C patent/CY2009017I1/el unknown
-
2011
- 2011-05-27 CY CY20111100515T patent/CY1111492T1/el unknown
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