AR035460A1 - Proceso para la preparacion de 10,11-dihidro-10-hidroxi-5h-dibenz/b,f/azepin-5-carboxamida y 10,11-dihidro-10-oxo-5h-dibenz/b,f/azepin-5-carboxamida - Google Patents
Proceso para la preparacion de 10,11-dihidro-10-hidroxi-5h-dibenz/b,f/azepin-5-carboxamida y 10,11-dihidro-10-oxo-5h-dibenz/b,f/azepin-5-carboxamidaInfo
- Publication number
- AR035460A1 AR035460A1 ARP020101958A ARP020101958A AR035460A1 AR 035460 A1 AR035460 A1 AR 035460A1 AR P020101958 A ARP020101958 A AR P020101958A AR P020101958 A ARP020101958 A AR P020101958A AR 035460 A1 AR035460 A1 AR 035460A1
- Authority
- AR
- Argentina
- Prior art keywords
- dibenz
- azepin
- carboxamide
- dihydro
- hydroxy
- Prior art date
Links
- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1h-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 230000008569 process Effects 0.000 title abstract 5
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- PGAKBXJPZAOAKB-UHFFFAOYSA-N 1h-azepine-3-carboxamide Chemical compound NC(=O)C1=CNC=CC=C1 PGAKBXJPZAOAKB-UHFFFAOYSA-N 0.000 abstract 5
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 4
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 abstract 4
- 239000003054 catalyst Substances 0.000 abstract 4
- 239000002184 metal Substances 0.000 abstract 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229960000623 carbamazepine Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000852 hydrogen donor Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112812.3A GB0112812D0 (en) | 2001-05-25 | 2001-05-25 | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035460A1 true AR035460A1 (es) | 2004-05-26 |
Family
ID=9915332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101958A AR035460A1 (es) | 2001-05-25 | 2002-05-24 | Proceso para la preparacion de 10,11-dihidro-10-hidroxi-5h-dibenz/b,f/azepin-5-carboxamida y 10,11-dihidro-10-oxo-5h-dibenz/b,f/azepin-5-carboxamida |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7241886B2 (https=) |
| EP (2) | EP1958938B1 (https=) |
| JP (3) | JP4323309B2 (https=) |
| KR (1) | KR100931916B1 (https=) |
| CN (2) | CN101172967A (https=) |
| AR (1) | AR035460A1 (https=) |
| AT (2) | ATE400560T1 (https=) |
| AU (2) | AU2002307863B8 (https=) |
| BR (1) | BR0210019A (https=) |
| CA (2) | CA2750876C (https=) |
| CY (3) | CY1108345T1 (https=) |
| CZ (1) | CZ303130B6 (https=) |
| DE (2) | DE60239842D1 (https=) |
| DK (2) | DK1958938T3 (https=) |
| ES (2) | ES2362688T3 (https=) |
| GB (1) | GB0112812D0 (https=) |
| HU (1) | HU230019B1 (https=) |
| LU (1) | LU91603I2 (https=) |
| MX (1) | MXPA03010793A (https=) |
| PL (1) | PL215305B1 (https=) |
| RU (2) | RU2311411C2 (https=) |
| SI (1) | SI1399424T1 (https=) |
| WO (1) | WO2002096881A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| ITMI20042230A1 (it) | 2004-11-19 | 2005-02-19 | Farchemia Srl | Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide |
| ITMI20042291A1 (it) * | 2004-11-26 | 2005-02-26 | Farchema S R L | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
| GB2422149A (en) * | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| US20060252745A1 (en) * | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| RU2012106827A (ru) | 2009-07-27 | 2013-09-10 | БИАЛ-ПОРТЕЛА энд КА., С.А. | Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии |
| US20150065704A1 (en) | 2011-07-13 | 2015-03-05 | Ketan Hirpara | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
| IN2015DN02296A (https=) | 2012-09-26 | 2015-08-21 | Ranbaxy Lab Ltd | |
| AU2016324165B2 (en) | 2015-09-16 | 2020-07-02 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective DNA sequencing |
| US12492423B2 (en) | 2015-09-16 | 2025-12-09 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective DNA sequencing |
| CN111943347B (zh) * | 2020-07-16 | 2022-08-30 | 同济大学 | 一种铜离子活化过氧乙酸去除废水中卡马西平的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439390B2 (https=) * | 1971-09-30 | 1979-11-27 | ||
| BE789320A (fr) | 1971-09-30 | 1973-03-27 | Takeda Chemical Industries Ltd | Derives de dibenzoxirenazepine |
| CH633271A5 (en) * | 1978-04-18 | 1982-11-30 | Ciba Geigy Ag | Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines |
| CH642950A5 (en) * | 1979-10-30 | 1984-05-15 | Ciba Geigy Ag | Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| IT1272897B (it) * | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| PT101876B (pt) * | 1996-05-27 | 1999-09-30 | Portela & Ca Sa | Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida |
| AT408224B (de) * | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxcarbazepin |
-
2001
- 2001-05-25 GB GBGB0112812.3A patent/GB0112812D0/en not_active Ceased
-
2002
- 2002-05-22 DK DK08075527.5T patent/DK1958938T3/da active
- 2002-05-22 WO PCT/GB2002/002356 patent/WO2002096881A1/en not_active Ceased
- 2002-05-22 KR KR1020037015323A patent/KR100931916B1/ko not_active Expired - Fee Related
- 2002-05-22 CZ CZ20033203A patent/CZ303130B6/cs not_active IP Right Cessation
- 2002-05-22 HU HU0400296A patent/HU230019B1/hu unknown
- 2002-05-22 ES ES08075527T patent/ES2362688T3/es not_active Expired - Lifetime
- 2002-05-22 EP EP08075527A patent/EP1958938B1/en not_active Expired - Lifetime
- 2002-05-22 PL PL366993A patent/PL215305B1/pl unknown
- 2002-05-22 BR BR0210019-3A patent/BR0210019A/pt active Search and Examination
- 2002-05-22 CA CA2750876A patent/CA2750876C/en not_active Expired - Fee Related
- 2002-05-22 RU RU2003137224/04A patent/RU2311411C2/ru active
- 2002-05-22 SI SI200230717T patent/SI1399424T1/sl unknown
- 2002-05-22 ES ES02774050T patent/ES2305299T3/es not_active Expired - Lifetime
- 2002-05-22 AT AT02774050T patent/ATE400560T1/de active
- 2002-05-22 CN CNA2007101939981A patent/CN101172967A/zh active Pending
- 2002-05-22 MX MXPA03010793A patent/MXPA03010793A/es active IP Right Grant
- 2002-05-22 AU AU2002307863A patent/AU2002307863B8/en not_active Ceased
- 2002-05-22 CA CA2448094A patent/CA2448094C/en not_active Expired - Lifetime
- 2002-05-22 US US10/478,770 patent/US7241886B2/en not_active Expired - Lifetime
- 2002-05-22 CN CN028105915A patent/CN1511141B/zh not_active Expired - Fee Related
- 2002-05-22 JP JP2003500061A patent/JP4323309B2/ja not_active Expired - Fee Related
- 2002-05-22 DK DK02774050T patent/DK1399424T3/da active
- 2002-05-22 DE DE60239842T patent/DE60239842D1/de not_active Expired - Lifetime
- 2002-05-22 EP EP02774050A patent/EP1399424B8/en not_active Expired - Lifetime
- 2002-05-22 DE DE60227517T patent/DE60227517D1/de not_active Expired - Lifetime
- 2002-05-22 AT AT08075527T patent/ATE506351T1/de active
- 2002-05-24 AR ARP020101958A patent/AR035460A1/es not_active Application Discontinuation
-
2007
- 2007-06-01 RU RU2007120532/04A patent/RU2449992C2/ru not_active IP Right Cessation
- 2007-10-04 AU AU2007221834A patent/AU2007221834B2/en not_active Ceased
-
2008
- 2008-08-05 JP JP2008201613A patent/JP2009057376A/ja active Pending
- 2008-09-17 CY CY20081100998T patent/CY1108345T1/el unknown
-
2009
- 2009-03-09 JP JP2009054515A patent/JP5280252B2/ja not_active Expired - Fee Related
- 2009-08-28 LU LU91603C patent/LU91603I2/fr unknown
- 2009-10-19 CY CY2009017C patent/CY2009017I1/el unknown
-
2011
- 2011-05-27 CY CY20111100515T patent/CY1111492T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR035460A1 (es) | Proceso para la preparacion de 10,11-dihidro-10-hidroxi-5h-dibenz/b,f/azepin-5-carboxamida y 10,11-dihidro-10-oxo-5h-dibenz/b,f/azepin-5-carboxamida | |
| Herranz et al. | Osmium-catalyzed vicinal oxyamination of olefins by N-chloro-N-argentocarbamates | |
| Tandon et al. | InBr3‐and AgOTf‐catalyzed beckmann rearrangement of (E)‐benzoheterocyclic oximes | |
| BRPI0408539B8 (pt) | processo para a oxidação parcial de acroleína para ácido acrílico em fase gasosa | |
| Yadav et al. | An easy access to unsymmetrical ureas: a photocatalytic approach to the Lossen rearrangement | |
| AR045868A1 (es) | Proceso para preparar compuestos de ocarbamoilo en presencia de grupo amina activa | |
| PT1442006E (pt) | Preparacao de anfetaminas a partir de fenilpropanolaminas | |
| Mukhopadhyay et al. | Direct Liquid‐Phase Sulfonation of Methane to Methanesulfonic Acid by SO3 in the Presence of a Metal Peroxide | |
| US20120171111A1 (en) | Process for production of oxidation reaction product of aromatic compound | |
| Zhang et al. | Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of α-amino acid esters using TBAI/TBHP | |
| CN112592247A (zh) | 一种光催化连续溴代的方法 | |
| Cho et al. | Synthesis of quinolines via ruthenium-catalysed amine exchange reaction between anilines and trialkylamines | |
| Remete et al. | Synthesis of novel fluorinated building blocks via halofluorination and related reactions | |
| Kitahara et al. | Gold nanoclusters as a catalyst for intramolecular addition of primary amines to unactivated alkenes under aerobic conditions | |
| AR050170A1 (es) | Metodo para la inversion quiral de (5) - (+) - y (r) - (-) -10,11-dihidro-10-hidroxi-5h-dibenz(b,f)azepina-5-carboxamida y mezclas opticamente enriquecidas de los mismos | |
| Rajeev et al. | C− H Bond Activation Facilitated by Nickel (II) Complexes Having Mighty Claws | |
| ES2287840T3 (es) | Procedimiento parta producir cicloalcanol y/o cicloalcanona. | |
| Zhao et al. | Direct synthesis of propylene carbonate from propylene and carbon dioxide catalyzed by quaternary ammonium heteropolyphosphatotungstate–TBAB system | |
| US20070117993A1 (en) | Novel multicomponent oxidation catalyst and process for producing epoxy compound therewith | |
| US20020045778A1 (en) | Method for oxidizing alkanes and cycloalkanes with aldehydes in the presence of copper-based catalysts and nitrogen-containing compounds | |
| Moriyama et al. | Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides | |
| Shefer et al. | General, fast, and high yield oxidation of thiols and disulfides to sulfonic and sulfinic acids using HOF· CH3CN | |
| KR102137669B1 (ko) | 메탄올 또는 그 전구체 합성용 촉매, 이의 제조방법 및 이를 이용한 메탄올 또는 그 전구체의 제조방법 | |
| PE20060018A1 (es) | Proceso para la preparacion de haluros de aril y hetoaril-alquilsulfonilo | |
| US10138188B2 (en) | Catalyst for producing methanol precursor, methanol precursor produced using the catalyst and methanol produced using the methanol precursor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FB | Suspension of granting procedure |