CY1107494T1 - Υποκατεστημενα παραγωγα πυριδυλμεθυλπιπepαζινης και πιπepιδινης, η παρασκευη τους και η χρηση τους για θepαπεια νοσων του κεντρικου νευρικου συστηματος (κνς) - Google Patents

Υποκατεστημενα παραγωγα πυριδυλμεθυλπιπepαζινης και πιπepιδινης, η παρασκευη τους και η χρηση τους για θepαπεια νοσων του κεντρικου νευρικου συστηματος (κνς)

Info

Publication number
CY1107494T1
CY1107494T1 CY20061100484T CY061100484T CY1107494T1 CY 1107494 T1 CY1107494 T1 CY 1107494T1 CY 20061100484 T CY20061100484 T CY 20061100484T CY 061100484 T CY061100484 T CY 061100484T CY 1107494 T1 CY1107494 T1 CY 1107494T1
Authority
CY
Cyprus
Prior art keywords
pyridylmethylpepazine
pipepidine
navy
producers
diseases
Prior art date
Application number
CY20061100484T
Other languages
English (en)
Inventor
Rw Feenstra
Hartog Jaj Den
Cg Kruse
M T M Tulp
Sk Long
Original Assignee
Duphar International Research B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research B.V. filed Critical Duphar International Research B.V.
Publication of CY1107494T1 publication Critical patent/CY1107494T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Η εφεύρεση σχετίζεται με μια ομάδα νέων ενώσεων πιπεραζίνης και πιπεριδίνης που έχουν ενδιαφέρουσες φαρμακολογικές ιδιότητες.
CY20061100484T 1997-09-24 2006-04-07 Υποκατεστημενα παραγωγα πυριδυλμεθυλπιπepαζινης και πιπepιδινης, η παρασκευη τους και η χρηση τους για θepαπεια νοσων του κεντρικου νευρικου συστηματος (κνς) CY1107494T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202950 1997-09-24
EP98203154A EP0908458B1 (en) 1997-09-24 1998-09-21 Substituted pyridylmethylpiperazine and piperidine derivatives, their preparation and their use for treating central nervous system (CNS) disorders

Publications (1)

Publication Number Publication Date
CY1107494T1 true CY1107494T1 (el) 2013-03-13

Family

ID=8228755

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100484T CY1107494T1 (el) 1997-09-24 2006-04-07 Υποκατεστημενα παραγωγα πυριδυλμεθυλπιπepαζινης και πιπepιδινης, η παρασκευη τους και η χρηση τους για θepαπεια νοσων του κεντρικου νευρικου συστηματος (κνς)

Country Status (31)

Country Link
US (2) US6090812A (el)
EP (1) EP0908458B1 (el)
JP (1) JP4191826B2 (el)
KR (1) KR100632188B1 (el)
CN (1) CN1093857C (el)
AR (1) AR017127A1 (el)
AT (1) ATE316529T1 (el)
AU (1) AU733526B2 (el)
BR (1) BR9803497A (el)
CA (1) CA2247734C (el)
CY (1) CY1107494T1 (el)
CZ (1) CZ296741B6 (el)
DE (1) DE69833297T2 (el)
DK (1) DK0908458T3 (el)
DZ (1) DZ2613A1 (el)
ES (1) ES2255127T3 (el)
HK (1) HK1018272A1 (el)
HU (1) HU227422B1 (el)
ID (1) ID20895A (el)
IL (1) IL126295A (el)
NO (1) NO312835B1 (el)
NZ (1) NZ331984A (el)
PL (1) PL190622B1 (el)
PT (1) PT908458E (el)
RU (1) RU2197488C2 (el)
SI (1) SI0908458T1 (el)
SK (1) SK285205B6 (el)
TR (1) TR199801866A1 (el)
TW (1) TW530054B (el)
UA (1) UA66756C2 (el)
ZA (1) ZA988749B (el)

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DK1140919T3 (da) * 1999-01-07 2002-12-30 Wyeth Corp 1,4-Disubstituerede cyclohexanderivater til behandling af depression
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
DE10005150A1 (de) 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en) 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7964604B2 (en) 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
CN101432279A (zh) 2006-05-02 2009-05-13 索尔瓦药物有限公司 吡啶基甲基哌嗪和吡啶基甲基哌啶衍生物的n-氧化物
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
WO2011088838A1 (en) 2010-01-25 2011-07-28 H. Lundbeck A/S Novel 6,6a,7,8,9,10-hexahydro-4h-4,8,10a-triaza-acephenanthrylene derivatives as dopamine d2 ligands
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
WO2018014829A1 (en) 2016-07-20 2018-01-25 Novartis Ag Aminopyridine derivatives and their use as selective alk-2 inhibitors
KR101665971B1 (ko) 2016-08-10 2016-10-13 (주)글로벌 로보틱스 차량용 발포패드 부착장치
JP2023502742A (ja) 2019-11-22 2023-01-25 インサイト コーポレーション Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法
IL298767A (en) 2020-06-16 2023-02-01 Incyte Corp ALK2 inhibitors for the treatment of anemia

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ATE81975T1 (de) 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
EP0185429A1 (en) * 1984-12-21 1986-06-25 Duphar International Research B.V New bicyclic heteroaryl piperazines
DE3782525T2 (de) * 1986-02-27 1993-05-27 Duphar Int Res Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung.
EP0508347A1 (en) 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use
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JPH05262765A (ja) 1992-03-18 1993-10-12 Sumitomo Chem Co Ltd ベンゾフラン誘導体およびそれを有効成分とする除草剤
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
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Also Published As

Publication number Publication date
DZ2613A1 (fr) 2003-03-01
NO984380L (no) 1999-03-25
AU733526B2 (en) 2001-05-17
DE69833297T2 (de) 2006-07-20
CA2247734A1 (en) 1999-03-24
KR100632188B1 (ko) 2007-04-25
AR017127A1 (es) 2001-08-22
TR199801866A1 (xx) 1999-04-21
IL126295A0 (en) 1999-05-09
USRE41425E1 (en) 2010-07-06
NO984380D0 (no) 1998-09-21
NZ331984A (en) 2000-02-28
KR19990029982A (ko) 1999-04-26
CN1220265A (zh) 1999-06-23
TW530054B (en) 2003-05-01
ES2255127T3 (es) 2006-06-16
ATE316529T1 (de) 2006-02-15
DE69833297D1 (de) 2006-04-13
AU8607998A (en) 1999-04-15
JPH11302279A (ja) 1999-11-02
PL190622B1 (pl) 2005-12-30
ID20895A (id) 1999-03-25
IL126295A (en) 2003-02-12
JP4191826B2 (ja) 2008-12-03
HU9802129D0 (en) 1998-11-30
CZ296741B6 (cs) 2006-06-14
CZ303098A3 (cs) 1999-04-14
BR9803497A (pt) 2000-05-02
PL328754A1 (en) 1999-03-29
HUP9802129A1 (hu) 2000-03-28
SK129498A3 (en) 1999-04-13
HK1018272A1 (en) 1999-12-17
PT908458E (pt) 2006-05-31
CA2247734C (en) 2007-08-07
SK285205B6 (sk) 2006-08-03
CN1093857C (zh) 2002-11-06
DK0908458T3 (da) 2006-06-06
HU227422B1 (en) 2011-05-30
UA66756C2 (uk) 2004-06-15
EP0908458B1 (en) 2006-01-25
SI0908458T1 (sl) 2006-06-30
ZA988749B (en) 1999-03-26
US6090812A (en) 2000-07-18
EP0908458A1 (en) 1999-04-14
RU2197488C2 (ru) 2003-01-27
NO312835B1 (no) 2002-07-08

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